Protein Alignment CG4049 and smarca4a

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: NP_853634.1
• Gene: smarca4a / 353295
• ZFINID: ZDB-GENE-030605-1
• Length: 1627
• Species: Danio rerio
• Alignment Length: 1778
• Identity: 356/1778 - (20%)
• Similarity: 558/1778 - (31%)
• Gaps: 719/1778 - (40%)

  Fly     4 PEANMEESNPNYD--VNQRLQKP------EGWPHVNEFHPSMMYPDDPRRYFHNASTDPQHQPQQ 60
            |...|::..||..  ..|....|      .|.|:.|..| .|:.|:.|...........|.||..
Zfish   235 PMPGMQQGMPNMPPASGQGAGPPGPGVPGPGGPNYNRPH-GMVGPNMPPPGPSGVPPGLQGQPTN 298

  Fly    61 HPQQQPEQHPEQHPQHPLHSQQQPQQHPQQ----QPQQHPQQQTQQ-PPQLQPQQHPQAQ----- 115
            .|       |:..|:.|:.:...|...||:    ||...|...... ||...|...||.|
Zfish   299 GP-------PKPWPEGPMVNAAAPASAPQKLIPPQPTGRPSPAPPSVPPAASPVMPPQTQSPGQP 356

  Fly   116 IQPPIPV--------PISTP---------------MEGTMEVPVKMPEYCP-------ETSQPVE 150
            .|||:.:        ||..|               ::..:...::..|..|       .|...:|
Zfish   357 AQPPMVLHQKQNRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKANIE 421

  Fly   151 PD--RVIN----------------PLAEVAKNTVPYGHKRKNSAGEDQAANKKLSMAAAEEKK-- 195
            ..  |::|                ...|.|.|...|...::.|..|.:...|.......|:::
Zfish   422 LKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKR 486

  Fly   196 --------NSHLR---------KNIRDVMNENNLDTTTLAA-----QREESERLAR------VAG 232
                    ||.|:         ::|...|.:......|..|     |::|:||:.:      :|.
Zfish   487 RQKHQEYLNSILQHAKDFKEYHRSITAKMQKLTKAVATYHANTEREQKKENERIEKERMRRLMAE 551

  Fly   233 QQKSMREIQKQVVHKQIFRIL-QLDE-----SEGIESCAVANPV---------------EHHPPV 276
            .::..|::..|...|::..:| |.||     :|.:.:...|..:               |...|.
Zfish   552 DEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRAHKAAQALKDKKKKKKKKKPENAEGGAPA 616

  Fly   277 DFPEEEIASDTFDDS----------NSSSLSG------GSIEDVL--HKGASVQP---SEVVTID 320
            ..|:.|...:|...|          :...|:|      |.::..|  :.|..|.|   ||    |
Zfish   617 LGPDGEPLDETSQMSDLPVKVIHVDSGKILTGMDAPKAGQLDTWLEMNPGYEVAPRSDSE----D 677

  Fly   321 DSSDDDCILLSEEEEEE-----------------DDEDLNESDDATNSGMHVKDIYNVPDENGQV 368
            ..||::     |::|||                 |.||::|. ||.:...|.|.  :|.||.|
Zfish   678 SGSDEE-----EDDEEEPQPSQAPTEEKKVIPDPDSEDVSEV-DARHIIEHAKQ--DVDDEYG-- 732

  Fly   369 VVNMAHPEGEETLY-----LAPQIAK--------VIKPHQIGGVRF---LYDNIIESTRRYNKSS 417
              |.|...|.::.|     :..::.|        .:|.:||.|:.:   ||:|.:..
Zfish   733 --NSAFIRGLQSYYAVAHAVTEKVEKQSSLLVNGQLKQYQIKGLEWLVSLYNNNLNG-------- 787

  Fly   418 GFGCILAHSMGLGKTLQVVSFCDIFLRHTSAK-TVLCVMPINTLQNWLSEFNMWIPRYSTDSNVR 481
                |||..||||||:|.::.....:...... ..|.::|::||.||:.||:.|.|.
Zfish   788 ----ILADEMGLGKTIQTIALITYLMEFKRLNGPFLIIVPLSTLSNWVYEFDKWAPS-------- 840

  Fly   482 PRNFDIFVLNDQQKTLTARAKVILNWVHDG--GVLLIGYELFRLLALKLVKTRKRKGSVIRPDGM 544
                   |:....|...|..:..|..:..|  .||:..||.       ::|.:
Zfish   841 -------VVKVSYKGSPAARRAFLPILRSGKFNVLVTTYEY-------IIKDK------------ 879

  Fly   545 DSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALK-EIRTRRRIVLTGYPLQNNLLEY 608
                       :.|.|.....:|.|||||:||.|..::..|. .....||::|||.||||.|.|.
Zfish   880 -----------QVLAKLRWKYMIVDEGHRMKNHHCKLTQVLNTHYLAPRRVLLTGTPLQNKLPEL 933

  Fly   609 WCMVDFVRPNYLGTRTEFCNMFERPI-QNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRRSHTV 672
            |.:::|:.|....:.:.|...|..|. ..|:.||...::..|:..|   ||.:|..|:.||....
Zfish   934 WALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRR---LHKVLRPFLLRRLKKE 995

  Fly   673 LQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVRTKAFPNPLKAFAVCCKIWNHPDVLYNFLKKC 737
            ::..||:|.||||...|:|.||                                  |||..::
Zfish   996 VEAQLPEKVEYVIKCDMSALQR----------------------------------VLYRHMQ-- 1024

  Fly   738 ETDLDLEIDEEVTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFNIPA 802
                        .||             :.|....||...|.|.
Zfish  1025 ------------AKG-------------VLLTDGSEKDKKGKGG--------------------- 1043

  Fly   803 SSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFES 867
                                                                             
Zfish  1044 ----------------------------------------------------------------- 1043

  Fly   868 ITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLK 932
                          .||:..||.      ||...||                     .|:
Zfish  1044 --------------TKTLMNTIM------QLRKICN---------------------HPY----- 1062

  Fly   933 SKQRNEEFSCSWAVDLMKNYVSGLISNSP------KMEIFFCILKESLNLGDRILLFSQSLLTLN 991
            ..|..||   |::..|  .:..|::..|.      |.|:...||.:......::|||.|....:.
Zfish  1063 MFQHIEE---SFSEHL--GFTGGIVQGSDLYRASGKFELLDRILPKLRATNHKVLLFCQMTTLMT 1122

  Fly   992 LLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERERLVNEFNANSN-VKLFLISTRAGSLGIN 1055
            ::|.|.  :|         :|..|.||||:|.:::|..|:..||..|: ..:||:|||||.||:|
Zfish  1123 IMEDYF--AY---------RNFKYLRLDGTTKAEDRGMLLKNFNDPSHQYFIFLLSTRAGGLGLN 1176

  Fly  1056 LTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKI---------YDRQIK 1111
            |..|:.|||||:.|||..|.||..|.:|.||.....|.|:.....:|:||         .|:::.
Zfish  1177 LQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVI 1241

  Fly  1112 KQGM--------------------------SDRIVDE---------------------------- 1122
            :.||                          .|.:.|:
Zfish  1242 QAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARSEEEFDHFMRMDLDRRREE 1306

  Fly  1123 -CNP--------EAHLS---MKDITNL----CQ-----------------DY-DS---------- 1143
             .||        |..|.   |||...:    |:                 || ||
Zfish  1307 ARNPKRRPRLMEEDELPTWIMKDDAEVERLTCEEEEEKMFGRGSRQRKEVDYSDSLTEKQWLKAI 1371

  Fly  1144 DEDTVEEV------------NKSTGDLSKPGSPSEEGSKPGSANMSPNASNKSNNGPTKPLDDQN 1196
            :|.|::|:            .|...||..||        |.:.:.|..:.:|.::|  |....:.
Zfish  1372 EEGTLDEIEEEVRHKKTTRKRKRDRDLDLPG--------PATPSSSGRSRDKDDDG--KKQKKRG 1426

  Fly  1197 TPKSPNGASHSPIKTEKNDGQEHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQA- 1260
            .|.:...:.:.|..|:|....     ||.:|.                    ..|...|:||:.
Zfish  1427 RPPAEKLSPNPPSLTKKMKKT-----VDAVIK--------------------YKDGNGRQLSEVF 1466

  Fly  1261 ----EKRQAHRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPMNQQIKTNTSSSTGGRST 1321
                .:::....|||.:|....::.........|:.:|:
Zfish  1467 IQLPSRKELPEYYELIRKPVDFRKIKERIRSHKYRSLND-------------------------- 1505

  Fly  1322 RWIPADVWQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRVMVLKSAKGIYMQLDSGKIIAI 1386
                               |..||::...:|...|:              :|..:..||..:.::
Zfish  1506 -------------------LEKDVMLLCQNAQTFNL--------------EGSLIYEDSIVLQSV 1537

  Fly  1387 RTTAKTEPEKTNKDDVIDITDDGDTDTTKPQSPEEDVKDLTADDEPRVVKNK------------- 1438
            .|:.:.:.||..::      .:||     ....|||..|..::.|.|.||.|
Zfish  1538 FTSVRQKIEKEEEE------SEGD-----DSEEEEDDVDEGSESESRSVKVKIKLSRKDKAERGK 1591

  Fly  1439 -ESNPATTSRPEMPAKDRKSTEN 1460
             ......:|||:....|..|.|:
Zfish  1592 GRRRTGRSSRPKPVVSDDDSEED 1614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	70/269 (26%)
		HepA	<392..1121	CDD:440319	173/778 (22%)
smarca4a	NP_853634.1	Med15	<65..>360	CDD:312941	33/132 (25%)
		QLQ	198..231	CDD:462622
		Smc	<382..>624	CDD:440809	39/241 (16%)
		HSA	478..550	CDD:214727	12/71 (17%)
		BRK	629..672	CDD:462196	7/42 (17%)
		DEXHc_SMARCA4	743..993	CDD:350820	79/309 (26%)
		PLN03142	762..>1244	CDD:215601	170/750 (23%)
		SnAC	1301..1368	CDD:464219	12/66 (18%)
		Bromo_SNF2L2	1440..1545	CDD:99947	24/188 (13%)