Protein Alignment CG4049 and ercc6l

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: XP_002936822.1
• Gene: ercc6l / 100135235
• XenbaseID: XB-GENE-988849
• Length: 1361
• Species: Xenopus tropicalis
• Alignment Length: 1536
• Identity: 310/1536 - (20%)
• Similarity: 524/1536 - (34%)
• Gaps: 520/1536 - (33%)

  Fly   272 HHPPVDFPEEEIASDTFDDSNSSSLSGGSIEDVLH---KGASVQPSEVV--TIDDSSDDDCILLS 331
            |...|: ||:....:.:........:.|::|..:.   |.:.:.||:.:  .|:...:    .|.
 Frog    18 HRSRVE-PEQVERYELYVKKAKQEATSGNLEKAIKFFVKASEIHPSDKIHRRIEKLKE----ALE 77

  Fly   332 EEEEEEDDEDLNESDDATNSGMHV-KDIYNVPDENGQVVVNMAHPEGEETLYLAPQIAKVIKPHQ 395
            |.:.:||.:|  :..|..|||:.: .::||                            |:.: ||
 Frog    78 ELDLQEDADD--DFVDVLNSGLTIYNELYN----------------------------KLFE-HQ 111

  Fly   396 IGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTL 460
            ..||.|||     |..|..:..|   |||..||||||:||:.|..........|.||.|||...:
 Frog   112 KEGVAFLY-----SLYRDGRKGG---ILADDMGLGKTIQVIGFLSGMFDSELIKYVLLVMPTTLI 168

  Fly   461 QNWLSEFNMWIPR------YSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYE 519
            .||:.||..|.|.      :.|....|.||     |...|:.              .|:::..|:
 Frog   169 SNWVKEFQKWTPGLRVAEFHGTSKKERTRN-----LEKIQRM--------------SGIIITTYQ 214

  Fly   520 LFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGP----DLVICDEGHRIKNSHAG 580
            :                             |:|...:.....|.    |.:|.||.|:||.|...
 Frog   215 M-----------------------------LINNWQQLATYNGREFEWDYIILDEAHKIKTSSTK 250

  Fly   581 ISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFV-RPNYLGTRTEFCNMFERPIQNGQCVDSTP 644
            .:.:...|..:.||:|||.|:||||.|.|.:.||. :...|||...|...:|.||...:..|:||
 Frog   251 TAKSCHSIPAKNRILLTGTPIQNNLREMWALYDFACQGTLLGTSKTFKMEYENPITRAREKDATP 315

  Fly   645 DDIKLMRYRAHVLHSLLLGFVQRRSHTVLQ------------------LTLPQKYEYVILVKMTA 691
            .:..|....:..|..::..:..||:.:.:|                  .:|.:|.::::.|.::.
 Frog   316 GEKALGLKISENLMKIIQPYFLRRTKSDVQNKKTERTRAQDTSQGPSMPSLTRKNDFIVWVYLST 380

  Fly   692 FQRKLYDTFMT-----DVVRTKAFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTK 751
            .|..:|..|::     :::.|..  :||....:..|:.:||.:|
 Frog   381 IQEDVYRKFISLDQIKELLMTTR--SPLAELNILKKLCDHPRLL--------------------- 422

  Fly   752 GAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPS 816
                     ||.:.:.|.  ||      ||..:|.|
 Frog   423 ---------SARACIQLG--LE------GDDYHSNE----------------------------- 441

  Fly   817 FYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNE 881
                            ||                       |..:.:.|:.:  |.||
 Frog   442 ----------------EG-----------------------DHELVTKFDHL--SDEI------- 458

  Fly   882 IKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAV 946
                                                                             
 Frog   459 ----------------------------------------------------------------- 458

  Fly   947 DLMKNYVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTK 1011
                     ||..|.|:.:...:|.:....|.|.|:||||...|::::..|::           |
 Frog   459 ---------LIEESGKLLLLIDLLHKLKEEGHRTLVFSQSRKMLDMIDRILQN-----------K 503

  Fly  1012 NSSYFRLDGSTSSQERERLVNEFNANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQ 1076
            |....|:||:.:..|||:.::.|.:|:|..:.|::|:.|.:|:.||.|:||:|||.||||..|.|
 Frog   504 NFKVMRIDGTVALPEREKRISIFQSNNNYSVLLLTTQVGGVGLTLTAADRVVIFDPSWNPATDAQ 568

  Fly  1077 AVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQIKKQGMSDRIV-DECNPEAHLSMKDITNLCQD 1140
            ||.|.||.||.:...:||::....:|:|||.|||.|:.:..:.. |:.||..:.|.:::..|.
 Frog   569 AVDRAYRIGQQENVVIYRLITCGTVEEKIYRRQIFKESLIRQTTGDKKNPFRYFSKQELKELF-- 631

  Fly  1141 YDSDEDTVEEVNKSTGDLSKPGSPSEEGSKPGSANMSPNASNKSNNGPTKPLDDQNTPKSPNGAS 1205
                  ::|:...|:..:.             ..||.. |..|::....:.:...:|.:....:.
 Frog   632 ------SLEDTRTSSTQIQ-------------LQNMHA-AERKTDTRLDEHIAYLHTLQIFGISD 676

  Fly  1206 HSPIKTEKNDGQ-------EHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQAEKR 1263
            |..:...:...|       ||..:::..:....::    |..|..::|.|: ||..:....|..|
 Frog   677 HDLVYANELSSQEDNEYEDEHGQYIEQRVQKAHEL----VQMESQLNEQLM-DQIRKSTEGAWVR 736

  Fly  1264 QAHRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPMNQQIKTNTSSSTGGRSTRWIPADV 1328
            |...:.|..||.::.:...|:...:...:..:|...::..|...|..::|    |.....:||
 Frog   737 QISTAPEKPKKTSLPREKQYSSPPVTVDLTEDDVGEVSCHMTSLIINDSS----GEEDVDLPA-- 795

  Fly  1329 WQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRVMVLKSAKGIYMQLDSGKIIAIRTTAKTE 1393
                        .|..:. |.|....:.....|.::.:.|:::    :|....||.     .|.|
 Frog   796 ------------APFSIK-PLNGNSHSGDTSHAAEKPLKLENS----LQQSHEKIF-----DKQE 838

  Fly  1394 PEKTNKDDVIDITDDGDT-----DTTKPQSP--EEDVKDLTADDEPRVVKNKESNPATTSRPEMP 1451
            ....:...||:..||.:|     |.:||..|  |.......|:.||..:.:.|        ||:.
 Frog   839 EIIVSDSSVIETDDDRNTPSLKGDWSKPSPPVTEHISYSHPAEGEPIPIWHVE--------PEVC 895

  Fly  1452 AKDRKSTEN-VQHFKSQTQPNTTL------ATTTNQHQLPSDLTYSQPQQSHQQPQQQASQQ--Q 1507
            .|.|.|..| .:.|:.....:|.:      :.:.::..||.|..... ..|.::.:..||.:  :
 Frog   896 KKLRHSFGNRTEEFQQSCVTDTDMNDGLEASLSASKSHLPCDFNLVL-DDSMERDECNASMEGLE 959

  Fly  1508 PAQQPPPPAYKH--------------QNHLPAA-----GE----GYSNANSIQPNVPLPPHPGA- 1548
            .|.:....|.|:              :|.|..:     |:    ..|.||:.|.||....:.||
 Frog   960 GAMEISAAADKNAILVLEDSVENTSQRNGLEISMVSENGDMVVLDSSMANTSQRNVLGTSNKGAM 1024

  Fly  1549 ---------------------------PNSSEAPPPADSSYFQPKPFQHTYPPQYYDYYDNKHKS 1586
                                       .|.:|:...||         .|.......|:.:...:.
 Frog  1025 LVLENSTEDISQEGNISETSMKLEQEKKNLNESMETAD---------VHIKDCSKQDFKEYPLEG 1080

  Fly  1587 APPGSGYHINNYTSYGNLNF-APYHSNLHPPASYI---------------GAPSSYVNSN--VFP 1633
            ......:|||..:...|... |..|::......|.               |..|.||:.|  ||
 Frog  1081 EEDEKSFHINEVSGTDNNELQASVHTDSEDELEYFVSKKKTARRIYSDSEGESSVYVDENEKVF- 1144

  Fly  1634 RQHWSSVVNSSPASSESMR---------QPSYIGSTYPVNE 1665
                      ||.||.|::         ..|...|.:|:.:
 Frog  1145 ----------SPTSSPSVKGITASTPKLNKSISDSLFPLRQ 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	79/272 (29%)
		HepA	<392..1121	CDD:440319	172/763 (23%)
ercc6l	XP_002936822.1	LapB	<21..123	CDD:442196	29/142 (20%)
		HepA	<106..613	CDD:440319	173/765 (23%)
		DEXHc_ERCC6L	107..339	CDD:350759	80/288 (28%)
		MPH1	<482..753	CDD:440728	82/308 (27%)
		Spy	1305..>1359	CDD:443119