Sequence 1: | NP_004510.1 | Gene: | KCNQ3 / 3786 | HGNCID: | 6297 | Length: | 872 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_788300.3 | Gene: | KCNQ / 36071 | FlyBaseID: | FBgn0033494 | Length: | 993 | Species: | Drosophila melanogaster |
Alignment Length: | 923 | Identity: | 281/923 - (30%) |
---|---|---|---|
Similarity: | 398/923 - (43%) | Gaps: | 299/923 - (32%) |
- Green bases have known domain annotations that are detailed below.
Human 73 GRDEGQRRTPQGIGLLAKTPL--SRPVKRNNAKYRRIQTLIYDALERPRG-WALLYHALVFLIVL 134
Human 135 GCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLC 199
Human 200 MLDIFVLIASVPVVAVGNQGNVLATS-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELIT 263
Human 264 AWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWE 328
Human 329 GRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRI 393
Human 394 DLVATWRFY--------------------ESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGS 438
Human 439 NTKGKLFTPL---------NVDAIEESPSKEP----------------------KPVGLNN---- 468
Human 469 -----------KERFRTAFR--------------MKA-------------YAFWQSS-------- 487
Human 488 --------------------------------------EDAGTGDPMAE-------------DRG 501
Human 502 YGNDFPIEDMI-----PTL-------KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGH 554
Human 555 LDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMM 619
Human 620 GKFVKVERQVQDMGKKLDFLVDMHMQHMERL---------------------------------- 650
Human 651 QVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYS--------ETGPPEPPYSFHQVTIDKV 707
Human 708 S----------------------------------------PYGFFAHDPVNLPRGGPSS--GKV 730
Human 731 QATPPSSATTYVE 743 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
KCNQ3 | NP_004510.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..43 | ||
Ion_trans | 139..363 | CDD:278921 | 125/224 (56%) | ||
Ion_trans_2 | 269..353 | CDD:285168 | 47/83 (57%) | ||
Selectivity filter. /evidence=ECO:0000250 | 316..321 | 3/4 (75%) | |||
Mediates interaction with calmodulin. /evidence=ECO:0000269|PubMed:27564677 | 356..537 | 67/344 (19%) | |||
KCNQ_channel | 452..656 | CDD:281513 | 70/372 (19%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 575..611 | 3/35 (9%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 764..872 | ||||
KCNQC3-Ank-G_bd | 780..866 | CDD:288784 | |||
KCNQ | NP_788300.3 | Ion_trans | 100..305 | CDD:278921 | 119/214 (56%) |
Ion_trans_2 | 221..295 | CDD:285168 | 47/83 (57%) | ||
KCNQ_channel | <619..719 | CDD:281513 | 48/128 (38%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 303 | 1.000 | Domainoid score | I1392 |
eggNOG | 1 | 0.900 | - | - | E1_COG2126 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 521 | 1.000 | Inparanoid score | I1271 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D1168835at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 1 | 1.000 | - | - | otm40696 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_102886 | |
Panther | 1 | 1.100 | - | - | O | PTHR11537 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X604 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
10 | 9.830 |