DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNQ3 and KCNQ

DIOPT Version :9

Sequence 1:NP_004510.1 Gene:KCNQ3 / 3786 HGNCID:6297 Length:872 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:923 Identity:281/923 - (30%)
Similarity:398/923 - (43%) Gaps:299/923 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    73 GRDEGQRRTPQGIGLLAKTPL--SRPVKRNNAKYRRIQTLIYDALERPRG-WALLYHALVFLIVL 134
            ||...:|.....:.||.| ||  :|..:| :.:|||:|:.:|:.|||||| .|:.||.:|||:|.
  Fly    23 GRPNSERILQPRMSLLGK-PLNYNRGTRR-DVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVF 85

Human   135 GCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLC 199
            .||.|:|.:|.||||..:...|..:|...:..|..||..|:|::||..||:|..|||||.::|.|
  Fly    86 TCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFC 150

Human   200 MLDIFVLIASVPVVAVGNQGNVLATS-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELIT 263
            ::||..::||:.|:.:|..|.|.||| ||.|||.|||||:||||||||||||||.:.||.:||||
  Fly   151 IIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELIT 215

Human   264 AWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWE 328
            ..|||||.||.:|||||:.||||          .::|..:|.|||||:|||.|:||||..|.||:
  Fly   216 TMYIGFLGLIFASFLVYMWEKDV----------NDKFSNFAQALWWGVITLCTVGYGDMVPITWQ 270

Human   329 GRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRI 393
            |:|||:..:|:|:|||||||||||||.|||||:|.||||..:||:|||.||||.||.||.:.:.:
  Fly   271 GKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSV 335

Human   394 DLVATWRFY--------------------ESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGS 438
            . ||||..:                    ..|...|..|:.:.:...:...|  |...:|.|.||
  Fly   336 S-VATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGG--DGGGVSKPPGS 397

Human   439 NTKGKLFTPL---------NVDAIEESPSKEP----------------------KPVGLNN---- 468
            :.....:|..         |::.::...|..|                      :|..|.|    
  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLS 462

Human   469 -----------KERFRTAFR--------------MKA-------------YAFWQSS-------- 487
                       :.|.|...|              .||             |.|...:        
  Fly   463 SSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSL 527

Human   488 --------------------------------------EDAGTGDPMAE-------------DRG 501
                                                  .|:.:|.|.:.             :.|
  Fly   528 RNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETG 592

Human   502 YGNDFPIEDMI-----PTL-------KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGH 554
            :.:..||.|:.     |..       |.|||.:|.|::.:.::||||.|:|||||||:|||:|||
  Fly   593 FSSPNPIIDVANEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGH 657

Human   555 LDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMM 619
            :|:|.|:|.|..|:|.|                     ...|.|...:.|.::        .|:.
  Fly   658 VDLLGRVKMLHLRLDQI---------------------LGKQGSKAKDVYASK--------ISLA 693

Human   620 GKFVKVERQVQDMGKKLDFLVDMHMQHMERL---------------------------------- 650
            .:.|||||||.|:.:|||.|:..:|:..:|.                                  
  Fly   694 SRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWK 758

Human   651 QVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYS--------ETGPPEPPYSFHQVTIDKV 707
            :......:|.:.|::|.......|:  |:|:::....:        .|..|.||:..|..|..|.
  Fly   759 RTAALSVHPEQVTTTPLLNPSAPDS--SELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKS 821

Human   708 S----------------------------------------PYGFFAHDPVNLPRGGPSS--GKV 730
            |                                        ||. .....:.:|..|..|  ...
  Fly   822 SVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYS-KQEQRITIPDEGADSLDSSA 885

Human   731 QATPPSSATTYVE 743
            :.|||.|:...::
  Fly   886 KPTPPDSSIILID 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQ3NP_004510.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Ion_trans 139..363 CDD:278921 125/224 (56%)
Ion_trans_2 269..353 CDD:285168 47/83 (57%)
Selectivity filter. /evidence=ECO:0000250 316..321 3/4 (75%)
Mediates interaction with calmodulin. /evidence=ECO:0000269|PubMed:27564677 356..537 67/344 (19%)
KCNQ_channel 452..656 CDD:281513 70/372 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..611 3/35 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..872
KCNQC3-Ank-G_bd 780..866 CDD:288784
KCNQNP_788300.3 Ion_trans 100..305 CDD:278921 119/214 (56%)
Ion_trans_2 221..295 CDD:285168 47/83 (57%)
KCNQ_channel <619..719 CDD:281513 48/128 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 303 1.000 Domainoid score I1392
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 521 1.000 Inparanoid score I1271
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1168835at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40696
orthoMCL 1 0.900 - - OOG6_102886
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X604
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.830

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