DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and SAS3

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_009501.1	Gene:	SAS3 / 852228	SGDID:	S000000148	Length:	831	Species:	Saccharomyces cerevisiae

Alignment Length:	956	Identity:	245/956 - (25%)
Similarity:	396/956 - (41%)	Gaps:	235/956 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 NDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRS---TIREKNVFESGKQSCA 491
            ||:......::...:....|...|....|:.:........:::|.|   .||.....:.|.....
Yeast     6 NDESPKPKKNALLKNLEIDDLIHSQFVRSDTNGHRTTRRLFNSDASISHRIRGSVRSDKGLNKIK 70

  Fly   492 KLSTGDGLGSPQNNELGSENWGFAAVAKN--------PI---------DIFVKSKHNSNVKGIGY 539
            |     ||.| |.::|.|||.....|.::        ||         ::.|:.|::| :|...:
Yeast    71 K-----GLIS-QQSKLASENSSQNIVNRDNKMGAVSFPIIEPNIEVSEELKVRIKYDS-IKFFNF 128

  Fly   540 SKPAASTFATSPAANR-VQKSTPV--------------------------ASSTPEKNS------ 571
            .:..:.:...:|..|: :..|.|:                          :.:||.:::
Yeast   129 ERLISKSSVIAPLVNKNITSSGPLIGFQRRVNRLKQTWDLATENMEYPYSSDNTPFRDNDSWQWY 193

  Fly   572 APIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRE-T 635
            .|.|| |||:.      |.....:::|        ..||.|.:||           .:|.|:. |
Yeast   194 VPYGG-TIKKM------KDFSTKRTLP--------TWEDKIKFLT-----------FLENSKSAT 232

  Fly   636 HSQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQMSNNHI--EKV 698
            :...:.....:|:.|...|..|:                         .|..|....|.:  .::
Yeast   233 YINGNVSLCNHNETDQENEDRKK-------------------------RKGKVPRIKNKVWFSQI 272

  Fly   699 NDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRHQNKC 763
            ..:.|::              ::|:.||:||||:...:...:|:|||||||..||....|||.||
Yeast   273 EYIVLRN--------------YEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKC 323

  Fly   764 IWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQ-- 826
            :..:|||.||:|.|.:||:|:||..|.:||||||||||.|::.||||||||||:|||||:.:.
Yeast   324 LTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTLYYDVEPFIFYILTEREDTE 388

  Fly   827 -------SGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEK 884
                   :..|.||||||||..:..||:|||||:|.|||:|||:||::|||||||:|.:.|||||
Yeast   389 NHPYQNAAKFHFVGYFSKEKFNSNDYNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEK 453

  Fly   885 PLSDLGRLSYFSYWKSVVLEYLYKHRN-------------YTKITFKDIAIKTGLAISDIALAFE 936
            ||||||.|:|.::||....|.|.|.|:             :.:::..|||..||:..:|:....|
Yeast   454 PLSDLGLLTYRTFWKIKCAEVLLKLRDSARRRSNNKNEDTFQQVSLNDIAKLTGMIPTDVVFGLE 518

  Fly   937 LLNFIKLRKNDG-----DIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLL-----S 991
            .|..:...|...     |..|.|.:. .|.:: .:..|..:||....::.|.|.|.|::     .
Yeast   519 QLQVLYRHKTRSLSSLDDFNYIIKID-SWNRI-ENIYKTWSSKNYPRVKYDKLLWEPIILGPSFG 581

  Fly   992 VSKLPNIIKPISNREYLSNQMETNSSFKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEK 1056
            ::.:.| ::|.:    |:::..||                 .|.:.|...::.:...|...:..|
Yeast   582 INGMMN-LEPTA----LADEALTN-----------------ETMAPVISNNTHIENYNNSRAHNK 624

  Fly  1057 LIDERENQRKRAYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGELSD-SSDCKSSKD--LSEQLT 1118
                |..:|:|:...:..|...|...:|::  |..:..:.:...|:: ..|.|::.:  |..|..
Yeast   625 ----RRRRRRRSSEHKTSKLHVNNIIEPEV--PATDFFEDTVSSLTEYMCDYKNTNNDRLIYQAE 683

  Fly  1119 KRAQRLAKRNDLIPHTN-----------KRKHFDRPLENNTTSTDHNPPAQSQADTAGTENGHKS 1172
            ||..........||.:.           ..|:.:.||.|:  :...|....|..:....|| ...
Yeast   684 KRVLESIHDRKGIPRSKFSTETHWELCFTIKNSETPLGNH--AARRNDTGISSLEQDEVEN-DVD 745

  Fly  1173 EETAAKENCKNVVEKEHVDKPVNIMPKLRGKQSNGKRSEEPQFNENPTSDPVAVASLSPAKEITR 1237
            .|....||.|   |.|..|:...:...:..:|.:.:..||....|..:.|
Yeast   746 TELYVGENAK---EDEDEDEDFTLDDDIEDEQISEENDEEEDTYEEDSDD--------------- 792

  Fly  1238 EPVKVAKTESPGKNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSD 1283
                  ..:...|.||..::|.|.:...::    |.|:.|.||..|
Yeast   793 ------DEDGKRKGQEQDENDIESHIRKER----VRKRRKITLIED 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	132/302 (44%)
		MOZ_SAS	768..947	CDD:280097	100/200 (50%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064	27/134 (20%)
SAS3	NP_009501.1	SAS2	67..571	CDD:227360	177/577 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S893
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103737
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.660