DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and Kat6b

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	XP_006519326.1	Gene:	Kat6b / 54169	MGIID:	1858746	Length:	2054	Species:	Mus musculus

Alignment Length:	2545	Identity:	652/2545 - (25%)
Similarity:	991/2545 - (38%)	Gaps:	767/2545 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :.:|||||:.||:.||||||.:|||.|:.|.|...:..|:|:||.:|:.|:|:||.||||.|||.
Mouse     9 YTEWILEAVQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKD 73

  Fly    79 PMAKRRVKVDK--------------------NTNLYKLVAKAVHDLGECEGSTIKSIENYIQKFN 123
            |....|....|                    |.:..||:.:|:..|.|..||::|:||.|::..:
Mouse    74 PDNPGRFSSVKPGTFPKPTKGSKGPPCNDLRNVDWNKLLKRAIEGLEEPNGSSLKNIEKYLRSQS 138

  Fly   124 CIDLSPNVD---FKAVIKASIKKAVDAGFLIQEGKLYK------KGKSL-----TTPRKCAPVSE 174
              ||:...:   |:..::...|:||:.|.|::||..|:      .||..     ..|....|||.
Mouse   139 --DLTGTTNHPAFQQRLRLGAKRAVNNGRLLKEGPQYRVNSGSSDGKGAPQYPSAFPSSLPPVSL 201

  Fly   175 VVIKGEES-------CTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYM 232
            :..:.::.       |:.|.|..:.|....||.|.||..||.|.|.:|........:.
Mouse   202 LPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTAN------- 259

  Fly   233 LVTKGTIWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SK 294
              .|...|.|..|..|:.|:::.: ...:|.|..|...||:.|.|....:.||..:.|:.|  .|
Mouse   260 --VKALRWQCIECKTCSACRVQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKK 322

  Fly   295 QGFDTPKLVKKDNSRIKMEAERMTPSYKYA------SNKRQ----SIKKDGNIESPSTSKLCVYN 349
            :|   .||:.:..::||.         :||      .||.:    |:..|....|..|.:   .:
Mouse   323 KG---RKLLHEKAAQIKR---------RYAKPIGRPKNKLKQRLLSVTSDEGSMSAFTGR---GS 372

  Fly   350 DGNGQRRKV---PASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSS 411
            .|.||:.||   |:|..:....||..:.......:..       ..::.|...|:...|:...:.
Mouse   373 PGRGQKTKVSTTPSSGHAASGKHSSSRLAVTDPTRPG-------ATTKTTTSSTYISASTLKVNK 430

  Fly   412 ESEDEDD--------EDDDRNRNGDDND-------QDESTSSDSCTS------------------ 443
            :::...|        ..|.|...|:..|       :.:.:...||||
Mouse   431 KTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPAPSAL 495

  Fly   444 ------SSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTGDGLGSP 502
                  |.....|.:|||.||                ||..:.:..:||:.|.:.|:
Mouse   496 LPPAPISGQSPSSQKSSSSTS----------------STSTQSSSSQSGEPSFSSLT-------- 536

  Fly   503 QNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKG-IGYSKPAASTFATSPAANRVQKSTPVASST 566
            .|::|.:...|.:.:        ..::..|..|| ..|:.|           .|:::.|..:|:.
Mouse   537 NNSQLKALFDGLSHI--------YTTQGQSRKKGHPSYAPP-----------KRMRRKTEFSSTA 582

  Fly   567 PEK---------------NSAPIGGMT----------------IKRQTANGQ-KKKIVPLKSMPL 599
            ..|               :|:...|||                :|:....|: |.|:.|....|
Mouse   583 KAKARFFGKRDFRSRLLSHSSCSWGMTRGHIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTP- 646

  Fly   600 EAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDEDAP-----GESTKRA 659
            .:||.                                |.|||:...:.|.|..     .:.:...
Mouse   647 SSGKG--------------------------------SLADGRINPDQDNDTDIKISIKQESADV 679

  Fly   660 NPFENQPLPPGVTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNT--QSPKSIQIGKWDI 722
            :...|:.|   ||..|::::     |...::|...||      .:||...  :.|..|:.||::|
Mouse   680 SLVGNKEL---VTEEDLDVF-----KQAQELSWEKIE------CESGVEDCGRYPSVIEFGKYEI 730

  Fly   723 ETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGN 787
            :||||||:|||||||.||:||||||||.||:::|.||..||.|..||..||:|:.::||||||||
Mouse   731 QTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGN 795

  Fly   788 VNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILT 852
            ::||||||||||||.|||||||||||||||||:|||||:.||||||||||||.|.||||||||:.
Mouse   796 MSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMI 860

  Fly   853 MPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITF 917
            |||:||||:|||||||||||||.|||.|:|||||||||||||.:|||||:|||||:|.. ..|:.
Mouse   861 MPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHE-RHISI 924

  Fly   918 KDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPD 982
            |.|:..||:...|||...:.|:.|..|  ||  |:.| ::.| |.:|.|..|:.|......::|:
Mouse   925 KAISRATGMCPHDIATTLQHLHMIDRR--DG--RFVI-IRRE-KLILGHMEKLKNCSRPNELDPE 983

  Fly   983 CLRWSPLLSVSKLPNIIKPISNRE---YLSNQMETNSSF----KEINEDKISVKQGVSTSSKVNQ 1040
            .|||:|:|    :.|.:.....||   .....||..|.:    :||...::|.:|   :|:||..
Mouse   984 SLRWTPML----ISNAVVSEEEREAEKEAERLMEQASCWEKEEQEILSSRVSSRQ---SSAKVQS 1041

  Fly  1041 ESSELSTKNRGP--------------SSEKLIDERENQRKRAYPEEFLKSASNEAKKPKLTAPQP 1091
            ::..|.:..|.|              |||:  :|.|.:......||..:..|.:...|:||.||
Mouse  1042 KNKYLHSPERRPVAGERGQLLELSKESSEE--EEEEEEEDDEEEEEEEEEESIQTSPPRLTKPQ- 1103

  Fly  1092 NLEDQSFGELSDSSDCKSSKDLSEQLTKRAQRLAKRNDLIPHTNKRKHFDRPLENNTTSTDHNPP 1156
                                  |..:.::...:.|:.    ...||:..:..:...|.|
Mouse  1104 ----------------------SVSIKRKRPFVVKKK----RGRKRRRINSSVTTETIS------ 1136

  Fly  1157 AQSQADTAGTENGHKSEETAAKENCKNVVEKEHVDKPVNIMPKLRGKQSNGKRSEEPQFNENPTS 1221
                             ||.  |......:....::|   ||:|                 .||.
Mouse  1137 -----------------ETT--EVLNEPFDNSDEERP---MPQL-----------------EPTC 1162

  Fly  1222 DPVAVASLSPAKEITREPV-KVAKTESPGKNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVA 1285
            :       .|.:|..|:|| :.|....|||.:::.:.:.|.|.                 |...|
Mouse  1163 E-------IPVEEGGRKPVLRKAFPHQPGKKRQTEEEEGEDNH-----------------FFKTA 1203

  Fly  1286 SYNTEDVKYNSEEKPMAIAQEPKESPTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHA 1350
            :...:||..::|.    :.:..|::|.....::..|.......:|.|..::..|..:.   :::.
Mouse  1204 ALCRKDVDDDAEH----LKEGSKDNPEPLKCRQVWPKGAKRGLSKWKQSKERKTGFKL---NLYT 1261

  Fly  1351 PVNT-----EKISTEESKLELDVHYLKLSPDSALNPPVASVQKPVPEPPAPKEKAKDLQAAQPSE 1410
            |..|     ::::.||.|        :||.|.  ..||.          ..:|..:.:.|..|.|
Mouse  1262 PPETPMEPEDQVTIEEQK--------ELSEDK--GSPVG----------MEREVTETVDALLPQE 1306

  Fly  1411 ALQKQPEIEMVKKTETKTETPVS--NPPSNRTDVSSLV------EQPVKAAPEKVEQPMVKEAVD 1467
            ..:::           :|..|||  ..|..:.|...|:      |:..:...|:.||...:|...
Mouse  1307 GSRRE-----------ETGIPVSPHKSPGGKVDEEDLIRGEEEGEEEGEEEGEREEQEEEEEVTT 1360

  Fly  1468 IKD----KALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHEKEAIKTDQQLVQVKEEEKSNARAP 1528
            .||    |:.:.|.|::.:.|.:.....   ||.:.:...|:.:...|.......:.....|...
Mouse  1361 EKDLDGAKSKENPEPEISMEKEDPVHLG---DHEEDEDEEEEPSHNEDHDADDEDDGHMEAANME 1422

  Fly  1529 SAPIPIRD--KIQLKGNEHAQLQNSI-PSQFPLNQMPNYHTSQYWQWEYYGYNLSHLDASQKGQK 1590
            ...:| |:  |..|:|.| |.|..|| ||......:.|           .|.:|:....|:.
Mouse  1423 RGDLP-RETFKDALEGQE-AFLDLSIQPSHSNPEVLMN-----------CGVDLTMSCNSEP--- 1471

  Fly  1591 QFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQMHQTKEKHKVERKNS----GKKEEQNKVVSS 1651
               |:||.             .:.......|.....||:   |.::|||    .:.||.......
Mouse  1472 ---KELAG-------------DTGTAPESDAEPPEEQTQ---KQDQKNSDGVDAELEEGGPAAVE 1517

  Fly  1652 VN------VVSTAREDAHVQHCNEY--AANNQAA---LYNQKCASQQKQ-------AQQM----- 1693
            ::      |.|..:|:.  :|.:.:  .|..|.|   |.|.....|..|       .||.
Mouse  1518 IDSETAQAVQSLTQENR--EHDDTFPDCAETQEACRSLQNYTHTDQSPQIATTLDECQQSDHSSP 1580

  Fly  1694 ---------KSLANVQNP-VPRQSNSNA---PESTVLMPNPVISQAGSVPAKQKVEHGVNSTSVI 1745
                     :|:.:|.:| ||...||.|   |:.|.:          :||..|.:|     ||.:
Mouse  1581 VSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQTAI----------TVPPLQNME-----TSPM 1630

  Fly  1746 SREGKLNKIGHSNIHATAQHANLQVGGGQSDV----NPNMVYNTESSANSAMQHYDCGISAQINM 1806
                       .::.:.:.|:...|..|.||:    :....|...||.:|.|....||..:..|.
Mouse  1631 -----------MDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNS 1684

  Fly  1807 DSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHMSIQNSHMQQQNNLNLNL 1871
            .|.:::.|            ||:             .||....|           ||.:|:
Mouse  1685 CSYSSLTS------------SNL-------------TQNSCAVT-----------QQMSNI---- 1709

  Fly  1872 APEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIRSGNTQQRDAKNAAPPTTT 1936
                |.:.::|.               ..::||| |:....:|:    |...:|      ||:::
Mouse  1710 ----SGSCSMLQ---------------QTSISSP-PTCSVKSPQ----GCVVER------PPSSS 1744

  Fly  1937 TNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIVGM 2001
                .|:.|...|||.:                     .|:....||:.|   :||...|:.:|.
Mouse  1745 ----QQLAQCSMAANFT---------------------PPMQLADIPETS---NANIGLYERMGQ 1781

  Fly  2002 PAVIQQRMSLNGSVHSLANSHQRIEQPSSACAVNNFYLQNNMPAAENAPRVPVSSSLGGPPTAGN 2066
            ............:..|||...|          :.|..:.:::|.:.:|
Mouse  1782 SDFGAGHYPQPSATFSLAKLQQ----------LTNTLIDHSLPYSHSA----------------- 1819

  Fly  2067 NDQRQAGQDSITT-ANSSGATASLAGNLCSLSKLQQLTNCLESQPCNTSPGAQVNLAPSPHHPIP 2130
                     ::|: |||:..:..|     |.:.|.||:....|.|  ..|.||..:.|.|:...|
Mouse  1820 ---------AVTSYANSASLSTPL-----SNTGLVQLSQSPHSVP--GGPQAQATMTPPPNLTPP 1868

  Fly  2131 PNSTPPPHLLMQNRNIS----TPPNMLQTQVTPLQYKYYPGNMNIPPITSAQNTSRNTRNTPSAP 2191
            |.:.||| ||.:|...|    :....||||                 |.|..:.|..|:....:|
Mouse  1869 PMNLPPP-LLQRNMAASNIGISHSQRLQTQ-----------------IASKGHVSMRTKAASLSP 1915

  Fly  2192 VQHTSTPMGSGNNRTA-------------NVHISPNLM-AP-------------YGAINSYRMSP 2229
            ...|......|.::|.             .:::|.||| ||             ..|:|.|.||
Mouse  1916 AAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMS- 1979

  Fly  2230 QQSPPTGSYSSGGDYPNS--QIPMQMM--NMQSQYQDACVLQRGTPSNPMY--PTYSPYL----- 2283
             |......|.|...|.|.  |.||||.  .|.||......:|....:|.||  |.:..|:
Mouse  1980 -QPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGSQPYAQQPMQTPPHANMMYTAPGHHGYMNTGMS 2043

  Fly  2284 --PLNGSIRR 2291
              .||||..|
Mouse  2044 KQSLNGSYMR 2053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056	19/59 (32%)
		PHD_SF	183..>215	CDD:304600	13/31 (42%)
		PHD	248..292	CDD:214584	12/44 (27%)
		NAT_SF	713..989	CDD:302625	176/275 (64%)
		MOZ_SAS	768..947	CDD:280097	127/178 (71%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064	72/408 (18%)
Kat6b	XP_006519326.1	H15	94..168	CDD:197772	20/75 (27%)
		PHD1_MOZ_MORF	213..270	CDD:277090	17/65 (26%)
		PHD2_KAT6A_6B	272..318	CDD:277002	12/45 (27%)
		PLN00104	<721..989	CDD:215056	176/274 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1831
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1032
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto93001
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3624
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970