DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and kat5b

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	XP_021331810.1	Gene:	kat5b / 503731	ZFINID:	ZDB-GENE-030131-985	Length:	555	Species:	Danio rerio

Alignment Length:	548	Identity:	187/548 - (34%)
Similarity:	269/548 - (49%)	Gaps:	127/548 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 AKLSTGDGL-----GSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGIGYSKPAASTFATS 550
            ||..|.:||     .||:..            .:..:|:.|:|   ::....|.:.|.....|.|
Zfish    76 AKTPTKNGLPGSRPSSPERE------------VRKSLDLNVQS---ASAPSRGKTLPTPKRKAES 125

  Fly   551 PA-ANRVQKSTPVAS--STPEKNSAPI------GGMTIKRQ---------TANGQKKKIVPLKSM 597
            .: |.:|..:|||.|  |:.|.:.|.:      ...:||.:         |.||..::::|  |.
Zfish   126 VSLATQVTAATPVPSLPSSAEASQASVYPAMRDSSFSIKAREEHEQLTSLTTNGTTRRLIP--SQ 188

  Fly   598 PLEAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDEDA------PGEST 656
            |   |:..:.|..     |||.|...|                     ||...:      |||.:
Zfish   189 P---GRKRKNCVG-----TEEIVKVFQ---------------------NNSPRSSTVYLPPGEDS 224

  Fly   657 KRANPFENQPLPPGVTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKWD 721
            :.::  :..|..|.:|.:   |..:..|..::....| |:                 .|::|:..
Zfish   225 QDSS--DGIPSAPRMTGS---LVSDRSHDDIITRMKN-ID-----------------CIELGRHR 266

  Fly   722 IETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRH-----------------QNKCIWKQPP 769
            ::.||.||:|||...|..|:||||||||.||...|.||                 :.||..:.||
Zfish   267 LKPWYFSPYPQELTTLPILYLCEFCLKYLKSLKCLQRHLVRAVLGPDVTHSQHQIKTKCNLRHPP 331

  Fly   770 GTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGY 834
            |.||:|:|.||.||:||..||:|.||||||||.||||||||||.:|||||::|:.|..|.|:|||
Zfish   332 GNEIYRKGTISFFEIDGRKNKMYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDSKGFHIVGY 396

  Fly   835 FSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWK 899
            |||||..|:.|||:||||:|.|||:|||:.||:|||.||:.||:.|||||||||||.|||.|||.
Zfish   397 FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWS 461

  Fly   900 SVVLEYLYKHRNYT----KITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQINVKIEW 960
            ..:||.|...::..    ::|..:|:..|.:...|:....:.||.|...|.    :|.:.:.
Zfish   462 QTILEILMNLKSENGERPQMTINEISEITSVKKEDVISTLQYLNLINYYKG----QYILTLS--- 519

  Fly   961 KKVLAHHNKMANSKTRIIIEPDCLRWSP 988
            :.::..|.: |..|..:.|:..||.::|
Zfish   520 EDIVEGHER-AMHKRHLRIDSKCLHFTP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	137/297 (46%)
		MOZ_SAS	768..947	CDD:280097	103/182 (57%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
kat5b	XP_021331810.1	Tudor-knot	8..66	CDD:314560
kat5b	XP_021331810.1	MOZ_SAS	<243..546	CDD:332306	139/328 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820