DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and kat5a

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_001002365.1	Gene:	kat5a / 436638	ZFINID:	ZDB-GENE-040718-57	Length:	541	Species:	Danio rerio

Alignment Length:	518	Identity:	181/518 - (34%)
Similarity:	256/518 - (49%)	Gaps:	112/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 NVKGIGYSKPAASTFATSPAANRVQKSTPVASSTPEKN------------SAPIGGMTI---KRQ 582
            ::|.:.:.|..|.|    |..|.:..|.|   |:||::            |||..|.|:   ||:
Zfish    65 DIKKLQFPKKEAKT----PMKNGLSGSRP---SSPERDVKKSLDLHVQSASAPSRGKTVPTPKRK 122

  Fly   583 TAN----GQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRETHSQADGKR 643
            ..:    .|.....|:.|:|    .|.|..:..:.....:....:       :|||.|
Zfish   123 AESVSLATQVTAATPVPSLP----ASTEASQAALYTAIRDASFNI-------KSREEH------- 169

  Fly   644 EMNNDEDAPGESTKRANPFENQPLPP---------GVTATDVELYQEVLHKAVVQMSNNHIEKVN 699
                 |.....:|......:...:||         |.|...|:::|            |:..:.:
Zfish   170 -----EPLTSLTTNGTTSIQRHLIPPQPGRKRKNCGGTDEMVKVFQ------------NNSPRCS 217

  Fly   700 DVSLKSGQNTQ--------SPK----------------------SIQIGKWDIETWYSSPFPQEY 734
            .|.|..|:::|        :|:                      .|::|:..::.||.||:|||.
Zfish   218 TVYLLPGEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIGCIELGRHRLKPWYFSPYPQEL 282

  Fly   735 ARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLL 799
            ..|..::||||||||.||...|.||..||..:.|||.||:|:|.||.||:||..||.|.||||||
Zfish   283 TSLPIIYLCEFCLKYLKSLKCLQRHLTKCNLRHPPGNEIYRKGTISFFEIDGRKNKAYSQNLCLL 347

  Fly   800 AKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRF 864
            ||.||||||||||.:|||||::|:.|..|.|:||||||||..|:.|||:||||:|.|||:|||:.
Zfish   348 AKCFLDHKTLYYDTDPFLFYVMTEYDPKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKL 412

  Fly   865 LIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYL--YKHRN--YTKITFKDIAIKTG 925
            ||:|||.||:.||:.|||||||||||.|||.|||...:||.|  .|..|  ..:||..:|:..|.
Zfish   413 LIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMDLKSENGERPQITINEISEITS 477

  Fly   926 LAISDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSP 988
            :...|:....:.||.|...|.    :|.:.:..:    :...::.|..|..:.|:|.||.::|
Zfish   478 IKKEDVISTLQYLNLINYYKG----QYILTLSED----IVEGHECAMQKRHLRIDPKCLHFTP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	139/302 (46%)
		MOZ_SAS	768..947	CDD:280097	106/182 (58%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
kat5a	NP_001002365.1	Tudor-knot	8..65	CDD:288553	181/518 (35%)
		NAT_SF	247..535	CDD:302625	139/294 (47%)
		MOZ_SAS	316..499	CDD:280097	106/186 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920