DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and e(y)3

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_001259719.1	Gene:	e(y)3 / 32965	FlyBaseID:	FBgn0087008	Length:	2012	Species:	Drosophila melanogaster

Alignment Length:	1461	Identity:	275/1461 - (18%)
Similarity:	483/1461 - (33%)	Gaps:	438/1461 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1000 KPISNREYLSNQMETNSSFKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEKLIDERENQ 1064
            :|.||....||.....:|.....|.::|     ||||...::....:.::|....|   .:::.|
  Fly    41 RPQSNCSANSNAKSVAASSTSEEEQRVS-----STSSPAQRDQQLNADRDREQEPE---PQQQQQ 97

  Fly  1065 RKRAYPEEFLK-------SASNEAKKPKLTAP---QPNLEDQSFGELSDSSDCKSSKDL------ 1113
            |:.|...:..:       :||.....|..|.|   .|:....|....|.|.:..|:...
  Fly    98 REEALQHQHNQPGHITSTTASPPPTLPPPTTPCDDAPSTTGASASASSASGEAPSAASAAGAAGG 162

  Fly  1114 ----------SEQ---------LTKRAQRLAKRNDLIPHTNKRKHFDRPLENNTTSTDHNPPAQS 1159
                      ||:         |:|.|...:..|:..|..::|:     :|          |.:.
  Fly   163 PMAATALEVESEERDGHKIILKLSKHANPNSNANESQPGGDERR-----VE----------PLRI 212

  Fly  1160 QADTAGTENGHKSEE----TAAKENCKNVVEKEHVDKPV--------NIMPKLRGKQSNGKR--S 1210
            |....|.|.|..:::    .|...:|.:...::.|...:        :|:|||..:.:|.:|  |
  Fly   213 QLPCGGAEGGLVAKQQDAFDADASSCSSSCAEDEVATTLGQQLRNTPHIVPKLTIRAANERRVGS 277

  Fly  1211 EEPQFNENPTSDPVAVASLSPAKEITREPVKVAKTESPGKN-------------QESAKHDAEPN 1262
            ..|:.......:|.|..|.|.:...: ..|..|::..|.||             ..||...:..:
  Fly   278 VVPKLTIKLPENPAASGSNSNSGSCS-AAVSGAQSAMPAKNDAHLSSLSPASASSSSASSSSSSS 341

  Fly  1263 SVSDQV-LDAVAKKTKKTLFSDVASYNTEDVKYNSEEKPMAIAQEPK------------------ 1308
            |.|... :..|.|...||..:..:..:      :|||.|....|.||
  Fly   342 SSSSLAEMQTVPKLMIKTTLAGSSCIS------SSEELPQQQQQIPKLTIKTGGGGQEHVHTVIM 400

  Fly  1309 -------ESPTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHAPVNTEKISTEESKLEL 1366
                   :|..:..|| ||.:|:.|.:..||..::...:.:..::::.:|.:..:...||
  Fly   401 THDLNNAQSIPKLTIK-TKSIEMIEDEQAAKLEQQLQPLPKLTIKNLCSPKHKVRAVLEE----- 459

  Fly  1367 DVHYLKLSPDSALNPPVA----SVQKPVPEP-PAPKEKAKDLQ----------------AAQPSE 1410
                         .||.|    ::.||.|.| |||.....:..                ||..|:
  Fly   460 -------------KPPTAASKLAIPKPTPNPTPAPMTNGGESNSSSQEFCGFSDPDADIAAPASD 511

  Fly  1411 ALQKQPEIEMVKKTETKTETP------VSNPPSNRTDVSSLVEQPVKAAPEKVEQPMVKEAVDIK 1469
            .:::..:..::..:.:|...|      ...|.||  .::|...:..||:.....|..|.:.||:.
  Fly   512 DVRRNSDDMVIDDSLSKEHDPKIFHNLPPMPASN--GIASGGSKASKASKSAQSQHNVVDMVDLT 574

  Fly  1470 DKALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHEK----EAIKTDQQL-VQVKEEEKSNARAPS 1529
            .             .|...|....:.::.|.....|    :.::....: ..|.||..|..|..:
  Fly   575 S-------------SPSPGSSPTHVPNNFTGRISPKGLLIDCLRMQTAIGCYVPEEADSRVRPAA 626

  Fly  1530 APIPIRDKIQLKGNEHAQL-QNSIPSQFPLNQMPNYHTSQYWQ-WEYYGYN-------------- 1578
            :|           |.:..| |.:.|::......|...:|:|.| .|....|
  Fly   627 SP-----------NSNILLSQLTAPAKSFTTTTPKSKSSKYPQLTERLMANGSGTGGGSVIAAES 680

  Fly  1579 ---LSHLDASQKGQKQFHK-------DLATTMAYTHN-----FTQNLYQSANLAMQHAHHQMHQT 1628
               :..|.|:...|.....       |.:..:||...     ..::|.....|||.|...|...|
  Fly   681 EAVVGPLPAANPAQSIIESIEILDTPDGSPRVAYMDEDSNPMLNKHLQTIHKLAMDHGVEQRMDT 745

  Fly  1629 KE---KHKVERKNSGKKEEQNKVVSSVNVVSTAR------EDAHVQHCNEYAANNQAALYNQKCA 1684
            ::   ::.::|.||    |.|:..||....|..|      .|...|:|::.|         :||:
  Fly   746 QDNNNENHLKRTNS----EGNESPSSRLPPSKQRRLDNDENDQQTQNCHDPA---------RKCS 797

  Fly  1685 --------SQQKQAQQMKSLANVQ------NPVPRQSNSNAPESTVL------------------ 1717
                    |.:.:.|:.:.:.|..      .|..:||.|...::..|
  Fly   798 ESLQALPPSHRSRKQKHERILNTDLEGSLFPPTQQQSISTPDQNGALSSEVEGEDAKAQDPLEPA 862

  Fly  1718 --MPNPVISQAGSVPAKQKVEHGVNSTS------VISREGKLNKIGHSNIHATAQHA-------- 1766
              .|.||.:.||:...:.:.:...|.:|      |..:.|...:..:|.:.:.....
  Fly   863 TPQPPPVATPAGTGKKRGRPKRIQNQSSPDGGGAVTPKPGTPQEEANSAVKSRRVQLLRKRLAID 927

  Fly  1767 NLQVGGGQSDVNPNMVYNTESSANSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHM 1831
            .:.||..|:|:...   ..|||........:.|::.  .::||...........:..:.::|.::
  Fly   928 MVSVGQEQADMKAK---EKESSVGVPNARVEDGLAE--TLESPKTRDHRPLRATRRTTTSTNTNL 987

  Fly  1832 HQP-----HRQFSDCSMQNQPVTTPMHMSIQNSHMQQQNNLNLNLAPEGSSNINLLSNPQHQHQS 1891
             ||     .::.|..|:|...:..|......:|..:..||.|.::                   |
  Fly   988 -QPTPKSTRKRQSKASVQQSQLPPPTMAQFGSSESESNNNNNSSI-------------------S 1032

  Fly  1892 RKLNAQADIAV--SSPTPSHRATTPKQIRSGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISK 1954
            ..|:||.|:.:  ||.:.|..|...:|:..|:    .:.:..||||..::...:|
  Fly  1033 FALSAQIDLTMCSSSSSTSSGAAANQQVIGGS----GSSSMLPPTTILSSSDPLP---------- 1083

  Fly  1955 SHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIVGMPAVIQQRMSLNGSVHSLA 2019
               |.:             .||.|:..|....|..|:.||:             :|...:..|..
  Fly  1084 ---DVI-------------FQPNDFSSIMATQQLRSSRPSS-------------ISCGSTGGSQP 1119

  Fly  2020 NSHQRIEQPSSACAVNNFYLQNNMPAAENAPRVPVSSS----LGGPPTAGNNDQRQA------GQ 2074
            :.|.                ::|..:|.:...|..|||    |..|||.|....|::      |.
  Fly  1120 DCHD----------------EDNYTSALDNSGVNSSSSDETALPMPPTRGRGRGRRSRGGRGRGS 1168

  Fly  2075 DSITTANSSGATASLAGNLCSLSKLQQLTNCLESQPCNTSPGAQV---NLAPS--------PHHP 2128
            .|:..|.|.|.|||             .|...:.:....|.||..   .:|.|        .|.|
  Fly  1169 SSVDRAVSVGGTAS-------------TTPATQPRAPRMSRGASAVAKAIAMSRPRCVGGLKHQP 1220

  Fly  2129 IPPN----STPPPHLLMQNRNISTP-PNMLQTQVTPLQYKYYPGNMNIPPIT-SAQNTSRNTRNT 2187
            .|..    .:|.|.:..::..:|.. .|..|:..:.::          ||:| ..|....|...:
  Fly  1221 DPERLKGLFSPSPQVFEEDTRMSADLSNSNQSMASLME----------PPLTPQKQPDFLNNEES 1275

  Fly  2188 PSAPVQHTSTPMGSGNNRTANVHISPNLMAP 2218
            .|:.|.:.|. |.|...::|:..:...|..|
  Fly  1276 QSSMVSNVSM-MDSNQGQSADAILGSALKRP 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625
		MOZ_SAS	768..947	CDD:280097
		Ehrlichia_rpt	<1150..>1539	CDD:118064	87/473 (18%)
e(y)3	NP_001259719.1	PHD_SF	1700..1754	CDD:304600
		RanBP2-type Zn finger	1700..1725	CDD:275375
		RanBP2-type Zn finger	1749..1775	CDD:275375
		PHD2_PHF10	1756..1799	CDD:277004
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930