DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment enok and Kat6a

DIOPT Version :9

Sequence 1:NP_001286823.1 Gene:enok / 37859 FlyBaseID:FBgn0034975 Length:2291 Species:Drosophila melanogaster
Sequence 2:NP_001094040.1 Gene:Kat6a / 306571 RGDID:1304892 Length:1998 Species:Rattus norvegicus


Alignment Length:2512 Identity:636/2512 - (25%)
Similarity:979/2512 - (38%) Gaps:757/2512 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :.|||||||.|::.||||||.:|||.|:.:.|......|.|:||.:|:.|.::||.||||:|||.
  Rat     9 YTQWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKD 73

  Fly    79 PMAKRRVKVDKNTN-----------LYKLVAKAVHDLGECEGSTIKSIENYI--QKFNCIDLSPN 130
            |....|:.:.|..|           ..||:.:|...|.|..|||:||||.::  ||    |:|..
  Rat    74 PDNPGRIALPKPRNHGKLDNKQSVDWNKLLKRAFEGLAESGGSTLKSIERFLKSQK----DVSAA 134

  Fly   131 V------DFKAVIKASIKKAVDAGFLIQEGKLYK--------KGK------------SLTTPRKC 169
            .      .|...::.:||:||..|.|:::|.||:        :||            ||....|.
  Rat   135 CGGTAASGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAANAEGKEGCESLSCLPPVSLLPHEKD 199

  Fly   170 APVSEVVIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYMLV 234
            .||:|.:    ..|:.|.|..::|....||.|.||..||.|.|.:|...:.....:         
  Rat   200 KPVAEPI----PICSFCLGTKEQNREKKPEDLISCADCGNSGHPSCLKFSPELTVR--------- 251

  Fly   235 TKGTIWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQG 296
            .:...|.|..|..|:.|:.:.: ...:|.|..|...||:.|.|....:.||..:.|:.|  .|:|
  Rat   252 VRALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKG 316

  Fly   297 FDTPKLVKKDNSRIKMEAERMTPSYKYAS---NKRQSIKKDGNIESPSTSKLCVYNDGNGQRRKV 358
               .||::|..::||.         :||:   ..:..:||...:.....||:.. ..|.|::||:
  Rat   317 ---RKLLQKKAAQIKR---------RYANPIGRPKNRLKKQSTVSKGPFSKVRT-GPGRGRKRKI 368

  Fly   359 PASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESEDEDDEDDDR 423
              ::||:..:.||:                |||                                
  Rat   369 --TVSSQSASSSEE----------------GYL-------------------------------- 383

  Fly   424 NRNGDDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQ 488
                     :.....|.|..||:                                          
  Rat   384 ---------ERIDGLDFCRDSSA------------------------------------------ 397

  Fly   489 SCAKLSTGDGLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGI--GYSKPAASTFATSP 551
                                            |:      |.|...||:  |.:|    .|..||
  Rat   398 --------------------------------PL------KFNKKTKGLIDGLTK----FFTPSP 420

  Fly   552 AANRVQKSTPVASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLT 616
                                             :|:|.:           |::.:..|       
  Rat   421 ---------------------------------DGRKAR-----------GEAVDYSE------- 434

  Fly   617 EETVMKVQLLEEIERSRET-HSQADGKREMNNDE-DAPGESTKRANPFENQPLPPGVTATDVELY 679
                  :::.::..|...| |...|     |.|. ::..||.:|.  |.:|.:   :|..|:||:
  Rat   435 ------LRIRKKGNRKSSTSHWPTD-----NQDGWESKQESEERL--FGSQEI---MTERDMELF 483

  Fly   680 QEVLHKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCE 744
            :::..:|        ::||. |:.......:.|..|:.||::|.||||||:||||:||.||:|||
  Rat   484 RDIQEQA--------LQKVG-VTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCE 539

  Fly   745 FCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTL 809
            |||||.|||::|.:|..||.|..||..||:|:.|||||||||||:.|||||||||||.|||||||
  Rat   540 FCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTL 604

  Fly   810 YYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSR 874
            ||||||||||:||:||..||||||||||||||.||||||||:.:|||||:||||||||||||||:
  Rat   605 YYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSK 669

  Fly   875 EEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLN 939
            .|||.|:|||||||||||||.:|||||:||.|| |:|..:|:.|.::..||:...||......|.
  Rat   670 REGQAGSPEKPLSDLGRLSYMAYWKSVILECLY-HQNDKQISIKKLSKLTGVCPQDITSTLHHLR 733

  Fly   940 FIKLRKNDGDIRYQINVKIEWKKVLAHH-NKMANSKTRIIIEPDCLRWSPLLSVSKLPNII---- 999
            .:       |.|....|.|..:|::..| .|:..:...:.::|:||||:|::    :.|.:    
  Rat   734 ML-------DFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI----VSNSVVSEE 787

  Fly  1000 -----------------KPISNREYL------SNQMETNSSFKEINEDKISVKQGVSTSSKVNQE 1041
                             :.:..||.:      .|:.:.:||..| :|.|..||: :::||:::::
  Rat   788 EDEEADDGEKEEPQGQERELETRERVGKSVSRENKDQDSSSLIE-SEKKPEVKE-LASSSRLSKQ 850

  Fly  1042 S---------------SELSTKNR-------GPSSEKLIDERENQRKRAYPEEFLKSASNEAKKP 1084
            :               .....|||       ...|:.|:.|..:..:..|.|...|||::..:..
  Rat   851 ALVRDSLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVGETLSTSQEQYGECEEKSAASRERYT 915

  Fly  1085 KL----TAPQPNLE---DQSFGELSDSSDCKSSKDLSEQLTKRAQRLAKRNDLIPHTNKRKHFDR 1142
            ::    .|||...:   |...|..|:|:|....     ||.|..:.|..|   :|..|       
  Rat   916 EVGEQPAAPQAQADGNPDIPKGRFSESADLWRG-----QLKKSPETLKCR---LPEGN------- 965

  Fly  1143 PLENNTTSTDHNPPAQSQADTA----GTENGHKSEE-TAAKENCKNVVEKEHVDKPVNIMPKLRG 1202
                     |..|...:..|.|    .:|:..:.|| .:.:.|          ..||...|.|:.
  Rat   966 ---------DRLPCCYTDGDRAVFRGFSESSEEEEEPESPRSN----------SPPVLTKPTLKR 1011

  Fly  1203 KQSNGKRSEEPQFNENPTSDPVAVASLSPAKEITREPVKVAKTESP-----------GKNQESAK 1256
            |:....|....:..::..|. |...::|...|:..||.:.:.:|.|           .:.:|..:
  Rat  1012 KKPILHRRRRVRKRKHHNSS-VVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIEEEEEEEDE 1075

  Fly  1257 HDAEP----NSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSEE-------KPMAIAQEPKES 1310
            ::..|    :.:|.|.:......:|:|     ||.:.|:.:..|::       ||:::.::...:
  Rat  1076 NELFPRGYFHCLSSQDILRCQASSKRT-----ASKDEEEEEEESDDADDTPVLKPVSLLRKCDVN 1135

  Fly  1311 PTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHAPVNTEKISTEESKLELDVHYLK--- 1372
            ........:.|::..:...|.|| .||                              :|:.|   
  Rat  1136 SASLEPDTSTPMKKKKGWPKGKS-RKP------------------------------IHWKKRPG 1169

  Fly  1373 LSPDSALNPPV--ASVQKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETKTETPVSNP 1435
            ..|...||..:  .|.|:.:.||..|.:..:..:..:..|.::.:..:...:|.|..||      
  Rat  1170 RKPGFKLNQDIIAVSTQECIVEPIVPIKPGRKPRTQESEELVEVKEGLVEERKEEMHTE------ 1228

  Fly  1436 PSNRTDVSSLVEQPVKAAPEKVEQPMVKEAVDIKDKALKKPV-----PDVPVVKPEATSCEKK-I 1494
                             |.|:.|:.....:.||:   ...|:     ||....:|||...|:| :
  Rat  1229 -----------------ADEEAEEEEDAASSDIR---AMSPLDSSNSPDADPKEPEAEEEEEKPL 1273

  Fly  1495 DHSKTKVFHEKEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQ---------N 1550
            |..:..   |:|    .|:|.:.::||:             |::..:.|::....         :
  Rat  1274 DDPRQS---EEE----PQELEEQEQEEE-------------DEVTAEANQNEDHDADDEDDGHLD 1318

  Fly  1551 SIPSQFPLNQMPNYHTSQYWQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTH----NFTQNLY 1611
            |:.::.|..|......:     |..|...|.||||.:..::..||...|.|.:.    :...::.
  Rat  1319 SLKTKEPEGQPAREDGT-----EEPGTQESFLDASIQDSRENAKDKDETEADSEEEQPSHEASVG 1378

  Fly  1612 QSANLAMQHAHHQMHQTKE-----KHKVERKNSGKKEEQNKVVSSVNVVSTAREDAHVQHCNEYA 1671
            .......:..|.:...|||     |.:.|..:|....|..:.|.|:....::..:...|.|.|..
  Rat  1379 SETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETL 1443

  Fly  1672 ANNQAALYNQKCASQQKQAQQMKSLANVQNPVPRQSNSNAPESTVLMPNPVISQAGSVPAKQKVE 1736
            |..| .|.:.....:..|...::.....::..|..|..:.|..:|        ::.|.|:...:|
  Rat  1444 AACQ-TLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSV--------RSVSSPSMPALE 1499

  Fly  1737 HGVNSTSVISREGKLNKIGHSN--------IHATAQHANLQVGGGQSDV----NPNMVYNTESSA 1789
            .|.  |.:...:|.|:.....|        :.:.:.|:...|..|.||:    :....|...||.
  Rat  1500 SGY--TQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSY 1562

  Fly  1790 NSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHM 1854
            :|.|....||     |..|.    |:.::|  .:|::|::             .||..|.|....
  Rat  1563 DSTMGSSICG-----NNSSQ----SSCSYG--GLSSSSSL-------------TQNSCVVTQQMA 1603

  Fly  1855 SIQNS-HMQQQNNLNLNLAPEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIR 1918
            |:.|| .|.|||::      :.::|.|:.| ||.....|..:.|      .|.|......|.|..
  Rat  1604 SMGNSCSMLQQNSV------QPATNCNIKS-PQTCVVERPPSNQ------QPPPPPPPPPPPQQP 1655

  Fly  1919 SGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIP 1983
            ....||:.|....||.         ||                         ||...|....|.|
  Rat  1656 QPQPQQQAAPQPPPPQ---------PQ-------------------------QQPPPPPQQQPQP 1686

  Fly  1984 QISQNFSANPSNYDIVGMPAVIQQRMSLNGSVHSLANSHQRIEQPSSACAVNNFYLQNNMPAAEN 2048
                              |...||                  :.|.|.|::|     |:..||..
  Rat  1687 ------------------PPPPQQ------------------QPPLSQCSMN-----NSFTAAPM 1710

  Fly  2049 APRVPVSSSLGGPPTAGNND--QRQAGQDSITTANSSGATASLAGNLCSLSKLQQLTNCL----- 2106
            ...:|.|   ||   .||..  :|..|.....:.:...||.|||       |||||||.:     
  Rat  1711 IMEIPES---GG---TGNISIYERIPGDFGAGSYSQPSATFSLA-------KLQQLTNTIMDPHA 1762

  Fly  2107 ---ESQPCNTSPGAQVNLAP------SPHHPI--PPNS----TPPPHLLMQNRNISTP---PNML 2153
               ...|..||....|:|:.      :|.||:  .|.:    ||||:|.....|:::|   .||.
  Rat  1763 MPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLAPTTMNLTSPLLQCNMS 1827

  Fly  2154 QTQVTPLQYKYYPGNMNIP------------PITSAQNTSRNTRNTPSAPVQHTSTPMGSGNNRT 2206
            .|.:.....:...|.|.:.            |..:|.......|:.|:..:|.....:.......
  Rat  1828 ATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMN 1892

  Fly  2207 ANVHISP----NL----MAPYGAINSYRMSPQQSPPTGSYSSGGDYPN--SQIPMQMM--NMQSQ 2259
            ..|::.|    |:    |....|:|||||:  |.....||.|...|.|  :|.||||.  .|.||
  Rat  1893 MGVNLMPTPAYNVNSMNMNTLNAMNSYRMT--QPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQ 1955

  Fly  2260 YQDACVLQRGTPSNPMY--PTYSPYL--------PLNGSIRR 2291
            ......:|.....|.||  |::..|:        .|||...|
  Rat  1956 AYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMR 1997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
enokNP_001286823.1 H15 95..152 CDD:294056 23/64 (36%)
PHD_SF 183..>215 CDD:304600 13/31 (42%)
PHD 248..292 CDD:214584 12/44 (27%)
NAT_SF 713..989 CDD:302625 170/276 (62%)
MOZ_SAS 768..947 CDD:280097 124/178 (70%)
Ehrlichia_rpt <1150..>1539 CDD:118064 76/426 (18%)
Kat6aNP_001094040.1 Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794 1..144 54/138 (39%)
Required for nuclear localization. /evidence=ECO:0000250 52..166 40/117 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..93 5/20 (25%)
H15 85..162 CDD:197772 24/80 (30%)
Interaction with PML. /evidence=ECO:0000250 144..662 224/762 (29%)
PHD1_MOZ_MORF 205..262 CDD:277090 16/69 (23%)
PHD2_KAT6A_6B 264..310 CDD:277002 12/45 (27%)
Interaction with RUNX1-1. /evidence=ECO:0000250 312..662 177/581 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..377 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..464 6/28 (21%)
Catalytic. /evidence=ECO:0000250 486..776 175/306 (57%)
PLN00104 <502..776 CDD:215056 171/281 (61%)
Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250 505..808 173/314 (55%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 643..647 3/3 (100%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 652..658 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 783..947 31/165 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 982..1079 19/107 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1175 17/114 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1436 52/291 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1450..1567 22/126 (17%)
Interaction with PML. /evidence=ECO:0000250 1510..1735 73/342 (21%)
Interaction with RUNX1-2. /evidence=ECO:0000250 1510..1635 37/155 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..1702 24/147 (16%)
Required for activation of RUNX1-2. /evidence=ECO:0000250 1907..1942 13/36 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1755
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 545 1.000 Inparanoid score I1112
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D629545at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10615
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3624
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.070

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