DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and kat6a

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_001116784.4	Gene:	kat6a / 266966	ZFINID:	ZDB-GENE-021022-3	Length:	2246	Species:	Danio rerio

Alignment Length:	2733	Identity:	628/2733 - (22%)
Similarity:	982/2733 - (35%)	Gaps:	960/2733 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :..||||||.|::.||||||.:|||.|:...|......|.|.||.:|:.|:::||.||||:|||.
Zfish     9 YTTWILEAIKKVKKQKQRPSEERICNAVSMSHGLDRKTVLEHLELSVKDGSILKVSNKGLNSYKD 73

  Fly    79 PMAKRRVKVDK-------------------------------NTNLYKLVAKAVHDLGECEGSTI 112
            |....|:...|                               ..:..||:.:::..|.|..||::
Zfish    74 PDNPGRLSFPKPRAGGGGGGCGSGGGGGGGGGSSTSSSSKKPGLDWNKLIKRSLEGLHEPGGSSL 138

  Fly   113 KSIENYIQKFNCI-----------DLSPNVDFKAVIKASIKKAVDAGFLIQEGKLYK-KGKSLTT 165
            ||||.:::   |.           .:.|.: |...::.::|:|...|.::::|.|:: ..:|...
Zfish   139 KSIERFLK---CQADVAGYLSGSGSMGPGI-FHQQLRLALKRACSHGRVVKQGPLFRLVSRSSHD 199

  Fly   166 PRKCA-----------------PVSEVVIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHT 213
            ...|.                 ||:|.:    ..|:.|.|..::|.:..||.|.||..||.|.|.
Zfish   200 GTGCVSLDSLPPVRLLPHEQDRPVAEPI----PICSFCLGTKEQNRDKKPEELISCADCGNSGHP 260

  Fly   214 TCANIAGRCKSQSYVLLYMLVTKGTIWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDT 277
            :|...:.....:         .|...|.|..|..|:.|:.:.: ...:|.|..|...||:.|.|.
Zfish   261 SCLKFSPELTVR---------VKALWWQCIECKTCSSCQDQGKNADNMLFCDSCDRGFHMECCDP 316

  Fly   278 IPDKKPKHPYRCKTCSKQGFDTPKLVKKDNSRIKMEAERMTPSYKYASNKRQSIKKDGNIESPST 342
            ...:.||..:.|:.|.          .::..|            |...:|...||:.
Zfish   317 PLTRMPKGMWICQICR----------PREKGR------------KLLHDKAAQIKRR-------- 351

  Fly   343 SKLCVYNDGNGQRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSST 407
                 ||...|:.:..|..               |.|:     ::||
Zfish   352 -----YNAPLGRPKGRPGR---------------PFKK-----IRGG------------------ 373

  Fly   408 SSSSESEDEDDEDDDRNRNGDDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDT 472
                        ...|.|.|       :...|.|:..||...||.|||.           |.|..
Zfish   374 ------------GRGRRRRG-------AGGVDQCSQGSSSPHSSSSSSC-----------EGYPG 408

  Fly   473 DRSTIREKNVFESGKQSCAKLSTGDGLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGI 537
            |     ::.:|...:...|..|.                                 :.|...||:
Zfish   409 D-----DRMLFSLREDDSAHGSL---------------------------------RFNKKTKGL 435

  Fly   538 GYSKPAASTFATSPAANRVQKSTPVASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAG 602
               ..|.|.|.|               .:|:...|               :.::|..........
Zfish   436 ---IDALSKFFT---------------PSPDGRKA---------------RAEVVDYSQQYRMRK 467

  Fly   603 KSYEKCEDDIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDED-APGESTKRANPFENQP 666
            |...|.|.|                  :|:.:....:|..||   ||| .||.        ||
Zfish   468 KGNRKGEHD------------------DRTGDNQECSDSWRE---DEDKLPGH--------EN-- 501

  Fly   667 LPPGVTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFP 731
                :|..||||::.:...|        ::||. |:.......:.|..|:.||::|:||||||:|
Zfish   502 ----LTEKDVELFRHIQEIA--------LQKVG-VTGPPDPQMRCPSVIEFGKYEIQTWYSSPYP 553

  Fly   732 QEYARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNL 796
            |||:||.||:||||||:|.||||:|.:|..||.|..||..||:|:.::|||||||||:.||||||
Zfish   554 QEYSRLPKLYLCEFCLRYMKSRSILYQHMRKCNWFHPPANEIYRKDDVSVFEVDGNVSTIYCQNL 618

  Fly   797 CLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGY 861
            |||||.|||||||||||||||||:||:||..||||||||||||||.||||||||:.:|||||:||
Zfish   619 CLLAKLFLDHKTLYYDVEPFLFYVLTQNDNKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGY 683

  Fly   862 GRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGL 926
            ||||||||||||:.|||.|:|||||||||||||.:||:|||||.|::.|: .:::.:.::..||:
Zfish   684 GRFLIDFSYLLSKREGQPGSPEKPLSDLGRLSYMAYWRSVVLECLHEIRD-RQLSIRKLSKVTGI 747

  Fly   927 AISDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRII-IEPDCLRWSPLL 990
            ...||......||.:: :|.||.|      .:..:|::|:|.....:|.|:: ::||||||:|::
Zfish   748 CPQDITATLLNLNMLE-QKGDGVI------IMRREKLVANHMARLKAKPRLLEVDPDCLRWTPVI 805

  Fly   991 SVSKLPNIIKPISNREYLSNQMETNSSFKEINEDKISVKQGVSTSSKV--NQESSELSTKNRGPS 1053
                                  .||:...|...|:...::|.....::  :.:||.||...:|
Zfish   806 ----------------------VTNTVVSEGEGDEDEEEEGEEERKEIKPSHKSSPLSWHMKG-- 846

  Fly  1054 SEKLIDERENQRKR----AYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKDLS 1114
                  ||||:.::    |:|:       |::..|                  .||.|.:.  ||
Zfish   847 ------ERENEEEKQSFPAFPK-------NQSSPP------------------SSSVCNNV--LS 878

  Fly  1115 EQLTKRAQRLAKRNDLIPHTNKRKHFDRPLEN----NTTSTDHNPPAQ-SQADTAGTENGHKSEE 1174
            .:         :.::.:....:|:...||.:|    .........||: .:....|.|:....::
Zfish   879 PE---------RHSNFLAANGERRGPGRPPKNWLWGKVKDAPRTVPARPRKLKITGDEDDDDDDD 934

  Fly  1175 TAAKENCKNVVEKEHVDK----PVNIMPKL-----------------------------RGKQSN 1206
            ...:::.:...|:|..::    .|...|.|                             ||:...
Zfish   935 DEVEDDDEEEEEEEEDERTGINKVTASPSLHSALENEPDSTSACPMEPSRHLTVPPQRNRGRPPR 999

  Fly  1207 GKRSEEPQFNENPTSD--------------PVAVASLSPAKEITREPVKVAKTESP--------- 1248
            .||..:.:..|.|..|              ||:.|.:|.:.|...:..:.::..||
Zfish  1000 KKRGPKRRLGEEPGDDLPLLPNNTRLSEPLPVSPAYMSESSEDEEDEEEESRPRSPPILTKPTLG 1064

  Fly  1249 --GKNQESAK----------HDA---EPNSVSDQVLD---------------------------- 1270
              .|:|:|.:          |.:   |..|.:.:|||
Zfish  1065 LKSKSQKSLRKRRVRQRSHPHSSVVTETISETTEVLDEPFVDSDSERPMPRLEEETPFGTPLRCY 1129

  Fly  1271 AVAKKTKKTLFSDVASYNTEDVKYNSEE-------KPMAIAQEPKESPTEAGIKETKPL-EVPEQ 1327
            ..|:|........::..|..:    |||       ||:|:.:.|:.|......:||..: |||.:
Zfish  1130 TAARKHMGPALKSISRSNLSE----SEEDDPTPVLKPIAVLRRPETSDATQRTEETSEMPEVPVK 1190

  Fly  1328 KAKA-------------KSP-EKPATVAETVLQHVHAPVNTEKISTEESKLELDVHYLKLSPDSA 1378
            |.|.             |.| .||.:.|.               .|:::.|.:         .|:
Zfish  1191 KKKGWPKGKSRKPLHWKKRPGRKPGSGAG---------------QTDDTDLAV---------PSS 1231

  Fly  1379 LNPPVASVQKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETKTETPVSNPPSNRTDVS 1443
            .:||.:.::.    .|..|.::..||.||..|.   |.|.|..:.|..:.:.........:....
Zfish  1232 EDPPPSKIKM----KPGRKPRSYYLQRAQEEEV---QQEFEQSQLTSQQQQQQQQQQQQQQAQTD 1289

  Fly  1444 SLVEQPVKAAPEKVEQPMVKEAVDIKDKALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHEKEAI 1508
            :|.::  :.|.::..:.::.|                  :.||                .:|::.
Zfish  1290 NLAQE--EKACKRTARALISE------------------ISPE----------------KQKDSE 1318

  Fly  1509 KTDQQLVQVKEEE---KSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFPLNQMPNYHTSQYW 1570
            ..|...:|...|.   |...|.|               ::|.|.:::|...||:: |.....:..
Zfish  1319 DDDDDFLQGFRESSRPKKRGRPP---------------KNANLPSTVPKPPPLSE-PEEEDEEED 1367

  Fly  1571 QWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQMHQTKE--KHK 1633
            :|.               :::..:..:.||:.:.: ::.....||..|..|.....:..|  .::
Zfish  1368 RWT---------------EEKLSRPPSRTMSQSSS-SRVPQPRANTNMADAEEDEERDDEDCNNR 1416

  Fly  1634 VERKNS--------------------GKKEEQNKVVSSVNVVSTAR------EDAHVQHCNEYAA 1672
            |.||.:                    |:.||::...||    |..|      :||..|...|...
Zfish  1417 VSRKTATTPGSGSRRSDDHDADDEGDGRLEEKSDSSSS----SKRRKGQDSEDDAEEQEDEEDEE 1477

  Fly  1673 NNQAALYNQKCASQQKQAQQMKSLANVQNPVPR-----QSNSNAPESTVLMPNPVISQAGSVPAK 1732
            ....|    .....:::.|..:|..::|..|.|     |.:.:..|........|.:.:.....:
Zfish  1478 PPSPA----HTPPVKEEPQSSESFLDMQTNVARDYVSKQEDGDEDEDDAEAVQEVKNNSADTDER 1538

  Fly  1733 QKVEHGVNSTSVISREGKLNKIGHSNIHATAQHAN--------------LQVGGGQSDVNPNMVY 1783
            ::.|...::.:..:.|         .:.|.|..:.              |.:|...|..:|:  :
Zfish  1539 RRREQEESAAAAAAVE---------TVTAIADPSEPMDMQPLHVEDKTVLMMGAEHSHQHPD--F 1592

  Fly  1784 NTESSANSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPV 1848
            ..:.|......|:    |:::::::...:.|......||..|.|       |..:.||.     .
Zfish  1593 KDDLSHQQHTHHH----SSELDLETVQAVQSLTQGEAQEEDAES-------HEAYQDCE-----E 1641

  Fly  1849 TTPMHMSIQN-SHMQQQNNLNLNLAPE-GSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRA 1911
            |.....::|: ||..:.....|.|..| |:|..:.:.||    ....|..|:..:|:||     |
Zfish  1642 TLAACRTLQSYSHTGEGEEETLALVEECGASQHSPMPNP----PMPTLPNQSVRSVNSP-----A 1697

  Fly  1912 TTPKQIRSGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQP 1976
            .||..:..|       ...:.||.|..     ..||....|:..|..||.....      |||:.
Zfish  1698 LTPGPMEPG-------PGVSGPTGTGG-----GTGGGYTQITPEHPSSLSAPSL------QNMET 1744

  Fly  1977 IDYVPIPQIS---------------------QNFSANPSNYDIV---------------GMPAVI 2005
            ...:.:|.:|                     :|:. |||:||..               ||.|..
Zfish  1745 SPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYD-NPSSYDSTMGGGGNGGGNGSNGGGMSAAT 1808

  Fly  2006 QQRMSLNGSVHSLANSHQRIEQPSSACAVNN--------------------------FYLQNNMP 2044
            ...::.:.:..|.::|.   ..|||:.:..|                          ..:|...|
Zfish  1809 AAAVAASSTSSSSSSSS---ATPSSSSSQGNSCSFVSTPGLTSSSTGVGSQISMGSCSLIQQTGP 1870

  Fly  2045 AAENAPRVPVSSSLGG------------------------------PPTAGNNDQRQAGQ----- 2074
            ...|.|.   |:|.||                              ||:|....|::..|
Zfish  1871 GTTNGPG---SNSTGGVPQPPPPPPPTSASTPTCGIKSPQGCVIERPPSANQQQQKKVSQPPQQQ 1932

  Fly  2075 --------------------------------------DSITTANSSGATASL---------AGN 2092
                                                  :...:|.|.|...||         ||.
Zfish  1933 QNPQPQPPPSAPPPPPPQQQALSQCSMGNGFASMPMIMEIPESAGSGGGGRSLYDRMGQDFGAGG 1997

  Fly  2093 LCSLSKLQQLTNCL-----------------ESQPCNTSPGAQVNLAPSPHHPI---PPNSTPPP 2137
            . ||:|||||||.:                 .:....::||. ..||.|||.|:   .|..||||
Zfish  1998 Y-SLAKLQQLTNTIMDPHGMSYSHSAAVTSYATSVSLSNPGL-AQLASSPHPPLGQAQPTMTPPP 2060

  Fly  2138 HLLMQNRNISTPPNMLQTQVTPLQYKYYPGNMNIPPITSAQN--------------TSRNTRNTP 2188
            :|...:.|:.:|  ::|..:|       ..|:.:||....|.              .|:.::...
Zfish  2061 NLGSGSMNLGSP--LIQCNMT-------GANIGLPPTPHPQRLQGQMATVKGHIAIRSKASQIPA 2116

  Fly  2189 SAPVQHTSTPMGSGNNRTANVHISP----------NLMAPYGAINSYRMSP---------QQSPP 2234
            .:|.|.......||   ...:..||          |||....|.||..|:|         :.|.|
Zfish  2117 GSPHQQQLYSRSSG---AVTMQGSPRTLVQRGMMTNLMPTPAAYNSVNMNPLNAAMSAGYRMSQP 2178

  Fly  2235 --TGSYSSGGDYPN--SQIPMQ----MMNMQSQYQDACVLQRGTPSNPMY-----------PTYS 2280
              ...|.|...|.|  :|.|||    ||..|:..|..  :|.....|.||           |..|
Zfish  2179 MMNSGYHSNPPYMNQPAQYPMQMQMGMMGGQAYPQQP--MQPNHHGNMMYTGPSHHSYAGVPKQS 2241

  Fly  2281 PYL 2283
            ||:
Zfish  2242 PYM 2244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056	16/67 (24%)
		PHD_SF	183..>215	CDD:304600	13/31 (42%)
		PHD	248..292	CDD:214584	12/44 (27%)
		NAT_SF	713..989	CDD:302625	168/276 (61%)
		MOZ_SAS	768..947	CDD:280097	120/178 (67%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064	83/513 (16%)
kat6a	NP_001116784.4	H15	122..185	CDD:197772	15/66 (23%)
		PHD1_MOZ_MORF	226..283	CDD:277090	17/69 (25%)
		PHD2_KAT6A_6B	285..331	CDD:277002	12/45 (27%)
		NAT_SF	535..804	CDD:302625	168/276 (61%)
		MOZ_SAS	590..767	CDD:280097	120/178 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1990
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1342
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40591
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6499
SonicParanoid	1	1.000	-	-		X3624
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.960