DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment enok and KAT6B

DIOPT Version :9

Sequence 1:NP_001286823.1 Gene:enok / 37859 FlyBaseID:FBgn0034975 Length:2291 Species:Drosophila melanogaster
Sequence 2:NP_001357065.1 Gene:KAT6B / 23522 HGNCID:17582 Length:2073 Species:Homo sapiens


Alignment Length:2524 Identity:642/2524 - (25%)
Similarity:993/2524 - (39%) Gaps:706/2524 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :.:||||||.||:.||||||.:|||.|:.|.|...:..|:|:||.:|:.|:|:||.||||.|||.
Human     9 YTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKD 73

  Fly    79 PMAKRRVKVDK-------------------NTNLYKLVAKAVHDLGECEGSTIKSIENYIQKFNC 124
            |....|....|                   |.:..||:.:|:..|.|..||::|:||.|::..: 
Human    74 PDNPGRFSSVKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQS- 137

  Fly   125 IDLSP---NVDFKAVIKASIKKAVDAGFLIQEGKLYK------KGKSL-----TTPRKCAPVSEV 175
             ||:.   |..|:..::...|:||:.|.|:::|..|:      .||..     ..|....|||.:
Human   138 -DLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLL 201

  Fly   176 VIKGEES-------CTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYML 233
            ..:.::.       |:.|.|..:.|....||.|.||..||.|.|.:|........:.        
Human   202 PHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTN-------- 258

  Fly   234 VTKGTIWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQ 295
             .|...|.|..|..|:.|:::.| ...:|.|..|...||:.|.|....:.||..:.|:.|  .|:
Human   259 -VKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKK 322

  Fly   296 GFDTPKLVKKDNSRIKMEAERMTPSYKYA------SNKRQ----SIKKDGNIESPSTSKLCVYND 350
            |   .||:.:..::||.         :||      .||.:    |:..|....:..|.:   .:.
Human   323 G---RKLLHEKAAQIKR---------RYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGR---GSP 372

  Fly   351 GNGQRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESED 415
            |.||:.||..:.||   .|:....:..|:...:...:.| ..::.|...|:...|:...:.:::.
Human   373 GRGQKTKVCTTPSS---GHAASGKDSSSRLAVTDPTRPG-ATTKITTTSTYISASTLKVNKKTKG 433

  Fly   416 EDD--------EDDDRNRNGDDND-------QDESTSSDSCTSS--------------------- 444
            ..|        ..|.|...|:..|       :.:.:...||||.                     
Human   434 LIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPT 498

  Fly   445 --SSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTG-------DGLG 500
              |..|.||:.||..:.               |...:.:..:....|.:.|:|.       |||.
Human   499 PISGQSPSSQKSSTATS---------------SPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLS 548

  Fly   501 -----SPQNNELGSENWG----------FAAVAKNPIDIF----VKSKHNSNVKGIGYSKPAAST 546
                 ..|:.:.|..::.          .::.||:....|    ::|:..|:.....:.....|.
Human   549 HIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSI 613

  Fly   547 FATSPAANRVQKSTPVASSTPEKNSAPIGGMTIKRQTANGQ-KKKIVPLKSMPLEAGKSYEKCED 610
            |   .|....:::|                 .:|:....|: |.|:.|....| ..||.      
Human   614 F---KAIAHFKRTT-----------------FLKKHRMLGRLKYKVTPQMGTP-SPGKG------ 651

  Fly   611 DIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDEDAP-----GESTKRANPFENQPLPPG 670
                                      |..||:.:.:.|:|..     .:.:...|...|:.:   
Human   652 --------------------------SLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDV--- 687

  Fly   671 VTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNT--QSPKSIQIGKWDIETWYSSPFPQE 733
            ||..|::::     |...::|...||      .:||...  :.|..|:.||::|:||||||:|||
Human   688 VTEEDLDVF-----KQAQELSWEKIE------CESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQE 741

  Fly   734 YARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCL 798
            ||||.||:||||||||.||:::|.||..||.|..||..||:|:.::||||||||::|||||||||
Human   742 YARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCL 806

  Fly   799 LAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGR 863
            |||.|||||||||||||||||:|||||:.||||||||||||.|.||||||||:.|||:||||:||
Human   807 LAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGR 871

  Fly   864 FLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAI 928
            |||||||||||.|||.|:|||||||||||||.:|||||:||||| |.:...|:.|.|:..||:..
Human   872 FLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLY-HHHERHISIKAISRATGMCP 935

  Fly   929 SDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSVS 993
            .|||...:.|:.|.  |.||  |:.| ::.| |.:|:|..|:........::||.|||:|:|   
Human   936 HDIATTLQHLHMID--KRDG--RFVI-IRRE-KLILSHMEKLKTCSRANELDPDSLRWTPIL--- 991

  Fly   994 KLPNIIKPISNREYLSNQMETNSSFKEINED----KISVKQGVSTSSKVNQESSELSTKNR---G 1051
                    |||......:.|.....:.:.|.    :...::.:||.:...|..:::.:||:   .
Human   992 --------ISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHS 1048

  Fly  1052 PSSEKLIDER----ENQRKRAYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKD 1112
            |.|..:..||    |..::.:..||  :....|.::.:....:...|::...|..:..:.:||  
Human  1049 PESRPVTGERGQLLELSKESSEEEE--EEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSS-- 1109

  Fly  1113 LSEQLTKRAQRLAKRNDLIPHTNKRKHFDRPLENNTTSTDHNPPAQSQADTAGTENGHKSEETAA 1177
             ..:|||......||..  |...|:|...:....|::.|.......::......:|..:......
Human  1110 -PPRLTKPQSVAIKRKR--PFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQ 1171

  Fly  1178 KENCKNVVEKEHVDKPVNIMPKLRGKQSNGKR-SEEPQFNEN---PTSDPVA------VASLSPA 1232
            .|....:..:|...|||  :.|....|...|| :||.:..:|   ..:||..      .::|...
Human  1172 LEPTCEIEVEEDGRKPV--LRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEG 1234

  Fly  1233 KEITREPVKVAKTESPGKNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSE 1297
            .:...||:|..:....|..:..:|..              ..|.:||.|    ..|.    |...
Human  1235 SKDNPEPLKCKQVWPKGTKRGLSKWR--------------QNKERKTGF----KLNL----YTPP 1277

  Fly  1298 EKPMAIAQEPKESPTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHAPVNTEKISTEES 1362
            |.||    ||.|..|....|||         ::.|:...|..:.|.|.:...|.:..|:...||:
Human  1278 ETPM----EPDEQVTVEEQKET---------SEGKTSPSPIRIEEEVKETGEALLPQEENRREET 1329

  Fly  1363 KLELDVHYLKLSPDSALNPPVASVQKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETK 1427
                                    ..||....:|.||.:|.......|..:::.|.|..::.|.:
Human  1330 ------------------------CAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGE 1370

  Fly  1428 TETPVSNPPSNRTDVSSLVEQPVKAAPEKVEQPMVKEAVDIKDKALKKPVPDVPVVKPEATSCEK 1492
            .|....|           ||:....|                 |:.:|..|::...|.::...: 
Human  1371 EEEGGGN-----------VEKDPDGA-----------------KSQEKEEPEISTEKEDSARLD- 1406

  Fly  1493 KIDHSKTKVFHEKEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFP 1557
              ||.:.:...|:.:...|..     .:::.::...||.:   :|.:|......::..:..:...
Human  1407 --DHEEEEEEDEEPSHNEDHD-----ADDEDDSHMESAEV---EKEELPRESFKEVLENQETFLD 1461

  Fly  1558 LNQMPNYHTSQYWQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAH 1622
            ||..|.:...:...  ..|.:|:   ||...:.   |:||....               |:..:.
Human  1462 LNVQPGHSNPEVLM--DCGVDLT---ASCNSEP---KELAGDPE---------------AVPESD 1503

  Fly  1623 HQMHQTKEKHKVERKNSGKKEEQNK---------------VVSSVNVVSTAREDAHVQHCNEYAA 1672
            .:....::..|.::|||.:.:.:.|               .|.|:...|:.::|. .|.|    |
Human  1504 EEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDT-FQDC----A 1563

  Fly  1673 NNQAA---LYNQKCASQQKQ-------AQQM--------------KSLANVQNP-VPRQSNSNA- 1711
            ..|.|   |.|...|.|..|       .||.              :|:.:|.:| ||...||.| 
Human  1564 ETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQ 1628

  Fly  1712 --PESTVLMPNPVISQAGSVPAKQKVEHGVNSTSVISREGKLNKIGHSNIHATAQHANLQVGGGQ 1774
              |:.:.:          |||:.|.:|     ||.:           .::.:.:.|:...|..|.
Human  1629 ISPDQSAI----------SVPSLQNME-----TSPM-----------MDVPSVSDHSQQVVDSGF 1667

  Fly  1775 SDV----NPNMVYNTESSANSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPH 1835
            ||:    :....|...||.:|.|....||..:..|..|.:|:.|:        |.|.        
Human  1668 SDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSS--------SLTQ-------- 1716

  Fly  1836 RQFSDCSMQNQPVTTPMHMSIQNSHMQQQNNLNLNLAPEGSSNINLLSNPQHQHQSRKLNAQADI 1900
               |.|::                 .||.:|:        |.:.::|.               ..
Human  1717 ---SSCAV-----------------TQQMSNI--------SGSCSMLQ---------------QT 1738

  Fly  1901 AVSSPTPSHRATTPKQIRSGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQF 1965
            ::||| |:....:|:    |...:|      ||:::    .|:.|...|||.:            
Human  1739 SISSP-PTCSVKSPQ----GCVVER------PPSSS----QQLAQCSMAANFT------------ 1776

  Fly  1966 SQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIVGMPAVIQQRMSLNGSVHSLANSHQRIEQPSS 2030
                     .|:....||:.|   :||...|:.:|        .|..|:.|        ..|||:
Human  1777 ---------PPMQLAEIPETS---NANIGLYERMG--------QSDFGAGH--------YPQPSA 1813

  Fly  2031 ACA------VNNFYLQNNMPAAENAPRVPVSSSLGGPPTAGNNDQRQAGQDSITT-ANSSGATAS 2088
            ..:      :.|..:.:::|.:.:|                          ::|: |||:..:..
Human  1814 TFSLAKLQQLTNTLIDHSLPYSHSA--------------------------AVTSYANSASLSTP 1852

  Fly  2089 LAGNLCSLSKLQQLTNCLESQPCNTSPGAQVNLAPSPHHPIPPNSTPPPHLLMQNRNIS----TP 2149
            |     |.:.|.||:....|.|  ..|.||..:.|.|:...||.:.||| ||.:|...|    :.
Human  1853 L-----SNTGLVQLSQSPHSVP--GGPQAQATMTPPPNLTPPPMNLPPP-LLQRNMAASNIGISH 1909

  Fly  2150 PNMLQTQVTPLQYKYYPGNMNIPPITSAQNTSRNTRNTPSAPVQHTSTPMGSGNNRTA------- 2207
            ...||||                 |.|..:.|..|::...:|...|......|.::|.       
Human  1910 SQRLQTQ-----------------IASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPAR 1957

  Fly  2208 ------NVHISPNLM-AP-------------YGAINSYRMSPQQSPPTGSYSSGGDYPNS--QIP 2250
                  .:::|.||| ||             ..|:|.|.||  |......|.|...|.|.  |.|
Human  1958 TLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMS--QPMMNSGYHSNHGYMNQTPQYP 2020

  Fly  2251 MQ----MMNMQSQYQDACVLQRGTPSNPMY--PTYSPYL-------PLNGSIRR 2291
            ||    ||..|...|..  :|.....|.||  |.:..|:       .||||..|
Human  2021 MQMQMGMMGTQPYAQQP--MQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMR 2072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
enokNP_001286823.1 H15 95..152 CDD:294056 20/59 (34%)
PHD_SF 183..>215 CDD:304600 13/31 (42%)
PHD 248..292 CDD:214584 13/44 (30%)
NAT_SF 713..989 CDD:302625 176/275 (64%)
MOZ_SAS 768..947 CDD:280097 127/178 (71%)
Ehrlichia_rpt <1150..>1539 CDD:118064 72/398 (18%)
KAT6BNP_001357065.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..97 4/24 (17%)
H15 113..167 CDD:197772 18/55 (33%)
PHD1_MOZ_MORF 212..269 CDD:277090 17/65 (26%)
PHD2_KAT6A_6B 271..317 CDD:277002 13/45 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..409 11/55 (20%)
Negatively regulates HAT activity 361..717 71/444 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..531 15/103 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..583 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..663 7/56 (13%)
Catalytic 718..1008 183/307 (60%)
PLN00104 <721..989 CDD:215056 176/274 (64%)
Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358 752..1008 161/273 (59%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 856..860 3/3 (100%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 865..871 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1452 99/536 (18%)
BASP1 1435..>1564 CDD:310221 26/159 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1484..1538 10/71 (14%)
Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546 1560..2073 156/712 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1619 7/38 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 268 1.000 Domainoid score I1870
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 575 1.000 Inparanoid score I1041
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D629545at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto89430
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3624
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.930

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