|
Fly 14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
:.:||||||.||:.||||||.:|||.|:.|.|...:..|:|:||.:|:.|:|:||.||||.|||.
Human 9 YTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKD 73
Fly 79 PMAKRRVKVDK-------------------NTNLYKLVAKAVHDLGECEGSTIKSIENYIQKFNC 124
|....|....| |.:..||:.:|:..|.|..||::|:||.|::..:
Human 74 PDNPGRFSSVKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQS- 137
Fly 125 IDLSP---NVDFKAVIKASIKKAVDAGFLIQEGKLYK------KGKSL-----TTPRKCAPVSEV 175
||:. |..|:..::...|:||:.|.|:::|..|: .||.. ..|....|||.:
Human 138 -DLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLL 201
Fly 176 VIKGEES-------CTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYML 233
..:.::. |:.|.|..:.|....||.|.||..||.|.|.:|........:.
Human 202 PHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTN-------- 258
Fly 234 VTKGTIWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQ 295
.|...|.|..|..|:.|:::.| ...:|.|..|...||:.|.|....:.||..:.|:.| .|:
Human 259 -VKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKK 322
Fly 296 GFDTPKLVKKDNSRIKMEAERMTPSYKYA------SNKRQ----SIKKDGNIESPSTSKLCVYND 350
| .||:.:..::||. :|| .||.: |:..|....:..|.: .:.
Human 323 G---RKLLHEKAAQIKR---------RYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGR---GSP 372
Fly 351 GNGQRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESED 415
|.||:.||..:.|| .|:....:..|:...:...:.| ..::.|...|:...|:...:.:::.
Human 373 GRGQKTKVCTTPSS---GHAASGKDSSSRLAVTDPTRPG-ATTKITTTSTYISASTLKVNKKTKG 433
Fly 416 EDD--------EDDDRNRNGDDND-------QDESTSSDSCTSS--------------------- 444
..| ..|.|...|:..| :.:.:...||||.
Human 434 LIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPT 498
Fly 445 --SSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTG-------DGLG 500
|..|.||:.||..:. |...:.:..:....|.:.|:|. |||.
Human 499 PISGQSPSSQKSSTATS---------------SPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLS 548
Fly 501 -----SPQNNELGSENWG----------FAAVAKNPIDIF----VKSKHNSNVKGIGYSKPAAST 546
..|:.:.|..::. .::.||:....| ::|:..|:.....:.....|.
Human 549 HIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSI 613
Fly 547 FATSPAANRVQKSTPVASSTPEKNSAPIGGMTIKRQTANGQ-KKKIVPLKSMPLEAGKSYEKCED 610
| .|....:::| .:|:....|: |.|:.|....| ..||.
Human 614 F---KAIAHFKRTT-----------------FLKKHRMLGRLKYKVTPQMGTP-SPGKG------ 651
Fly 611 DIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDEDAP-----GESTKRANPFENQPLPPG 670
|..||:.:.:.|:|.. .:.:...|...|:.:
Human 652 --------------------------SLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDV--- 687
Fly 671 VTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNT--QSPKSIQIGKWDIETWYSSPFPQE 733
||..|:::: |...::|...|| .:||... :.|..|:.||::|:||||||:|||
Human 688 VTEEDLDVF-----KQAQELSWEKIE------CESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQE 741
Fly 734 YARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCL 798
||||.||:||||||||.||:::|.||..||.|..||..||:|:.::||||||||::|||||||||
Human 742 YARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCL 806
Fly 799 LAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGR 863
|||.|||||||||||||||||:|||||:.||||||||||||.|.||||||||:.|||:||||:||
Human 807 LAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGR 871
Fly 864 FLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAI 928
|||||||||||.|||.|:|||||||||||||.:|||||:||||| |.:...|:.|.|:..||:..
Human 872 FLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLY-HHHERHISIKAISRATGMCP 935
Fly 929 SDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSVS 993
.|||...:.|:.|. |.|| |:.| ::.| |.:|:|..|:........::||.|||:|:|
Human 936 HDIATTLQHLHMID--KRDG--RFVI-IRRE-KLILSHMEKLKTCSRANELDPDSLRWTPIL--- 991
Fly 994 KLPNIIKPISNREYLSNQMETNSSFKEINED----KISVKQGVSTSSKVNQESSELSTKNR---G 1051
|||......:.|.....:.:.|. :...::.:||.:...|..:::.:||: .
Human 992 --------ISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHS 1048
Fly 1052 PSSEKLIDER----ENQRKRAYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKD 1112
|.|..:..|| |..::.:..|| :....|.::.:....:...|::...|..:..:.:||
Human 1049 PESRPVTGERGQLLELSKESSEEEE--EEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSS-- 1109
Fly 1113 LSEQLTKRAQRLAKRNDLIPHTNKRKHFDRPLENNTTSTDHNPPAQSQADTAGTENGHKSEETAA 1177
..:|||......||.. |...|:|...:....|::.|.......::......:|..:......
Human 1110 -PPRLTKPQSVAIKRKR--PFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQ 1171
Fly 1178 KENCKNVVEKEHVDKPVNIMPKLRGKQSNGKR-SEEPQFNEN---PTSDPVA------VASLSPA 1232
.|....:..:|...||| :.|....|...|| :||.:..:| ..:||.. .::|...
Human 1172 LEPTCEIEVEEDGRKPV--LRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEG 1234
Fly 1233 KEITREPVKVAKTESPGKNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSE 1297
.:...||:|..:....|..:..:|.. ..|.:||.| ..|. |...
Human 1235 SKDNPEPLKCKQVWPKGTKRGLSKWR--------------QNKERKTGF----KLNL----YTPP 1277
Fly 1298 EKPMAIAQEPKESPTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHAPVNTEKISTEES 1362
|.|| ||.|..|....||| ::.|:...|..:.|.|.:...|.:..|:...||:
Human 1278 ETPM----EPDEQVTVEEQKET---------SEGKTSPSPIRIEEEVKETGEALLPQEENRREET 1329
Fly 1363 KLELDVHYLKLSPDSALNPPVASVQKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETK 1427
..||....:|.||.:|.......|..:::.|.|..::.|.:
Human 1330 ------------------------CAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGE 1370
Fly 1428 TETPVSNPPSNRTDVSSLVEQPVKAAPEKVEQPMVKEAVDIKDKALKKPVPDVPVVKPEATSCEK 1492
.|....| ||:....| |:.:|..|::...|.::...:
Human 1371 EEEGGGN-----------VEKDPDGA-----------------KSQEKEEPEISTEKEDSARLD- 1406
Fly 1493 KIDHSKTKVFHEKEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFP 1557
||.:.:...|:.:...|.. .:::.::...||.: :|.:|......::..:..:...
Human 1407 --DHEEEEEEDEEPSHNEDHD-----ADDEDDSHMESAEV---EKEELPRESFKEVLENQETFLD 1461
Fly 1558 LNQMPNYHTSQYWQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAH 1622
||..|.:...:... ..|.:|: ||...:. |:||.... |:..:.
Human 1462 LNVQPGHSNPEVLM--DCGVDLT---ASCNSEP---KELAGDPE---------------AVPESD 1503
Fly 1623 HQMHQTKEKHKVERKNSGKKEEQNK---------------VVSSVNVVSTAREDAHVQHCNEYAA 1672
.:....::..|.::|||.:.:.:.| .|.|:...|:.::|. .|.| |
Human 1504 EEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDT-FQDC----A 1563
Fly 1673 NNQAA---LYNQKCASQQKQ-------AQQM--------------KSLANVQNP-VPRQSNSNA- 1711
..|.| |.|...|.|..| .||. :|:.:|.:| ||...||.|
Human 1564 ETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQ 1628
Fly 1712 --PESTVLMPNPVISQAGSVPAKQKVEHGVNSTSVISREGKLNKIGHSNIHATAQHANLQVGGGQ 1774
|:.:.: |||:.|.:| ||.: .::.:.:.|:...|..|.
Human 1629 ISPDQSAI----------SVPSLQNME-----TSPM-----------MDVPSVSDHSQQVVDSGF 1667
Fly 1775 SDV----NPNMVYNTESSANSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPH 1835
||: :....|...||.:|.|....||..:..|..|.:|:.|: |.|.
Human 1668 SDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSS--------SLTQ-------- 1716
Fly 1836 RQFSDCSMQNQPVTTPMHMSIQNSHMQQQNNLNLNLAPEGSSNINLLSNPQHQHQSRKLNAQADI 1900
|.|:: .||.:|: |.:.::|. ..
Human 1717 ---SSCAV-----------------TQQMSNI--------SGSCSMLQ---------------QT 1738
Fly 1901 AVSSPTPSHRATTPKQIRSGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQF 1965
::||| |:....:|: |...:| ||::: .|:.|...|||.:
Human 1739 SISSP-PTCSVKSPQ----GCVVER------PPSSS----QQLAQCSMAANFT------------ 1776
Fly 1966 SQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIVGMPAVIQQRMSLNGSVHSLANSHQRIEQPSS 2030
.|:....||:.| :||...|:.:|.............:..|||...|
Human 1777 ---------PPMQLAEIPETS---NANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQ------- 1822
Fly 2031 ACAVNNFYLQNNMPAAENAPRVPVSSSLGGPPTAGNNDQRQAGQDSITT-ANSSGATASLAGNLC 2094
:.|..:.:::|.:.:| ::|: |||:..:..|
Human 1823 ---LTNTLIDHSLPYSHSA--------------------------AVTSYANSASLSTPL----- 1853
Fly 2095 SLSKLQQLTNCLESQPCNTSPGAQVNLAPSPHHPIPPNSTPPPHLLMQNRNIS----TPPNMLQT 2155
|.:.|.||:....|.| ..|.||..:.|.|:...||.:.||| ||.:|...| :....|||
Human 1854 SNTGLVQLSQSPHSVP--GGPQAQATMTPPPNLTPPPMNLPPP-LLQRNMAASNIGISHSQRLQT 1915
Fly 2156 QVTPLQYKYYPGNMNIPPITSAQNTSRNTRNTPSAPVQHTSTPMGSGNNRTA------------- 2207
| |.|..:.|..|::...:|...|......|.::|.
Human 1916 Q-----------------IASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQR 1963
Fly 2208 NVHISPNLM-AP-------------YGAINSYRMSPQQSPPTGSYSSGGDYPNS--QIPMQ---- 2252
.:::|.||| || ..|:|.|.|| |......|.|...|.|. |.|||
Human 1964 GMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMS--QPMMNSGYHSNHGYMNQTPQYPMQMQMG 2026
Fly 2253 MMNMQSQYQDACVLQRGTPSNPMY--PTYSPYL-------PLNGSIRR 2291
||..|...|.. :|.....|.|| |.:..|: .||||..|
Human 2027 MMGTQPYAQQP--MQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMR 2072
| 
