DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and mys-4

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_492265.1	Gene:	mys-4 / 183194	WormBaseID:	WBGene00007914	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	204/758 - (26%)
Similarity:	314/758 - (41%)	Gaps:	209/758 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 GFDTPKLVKKDNS----------RIKMEAERMTPSYKYASNKRQSIKKDGNIESPSTSKLCVYND 350
            |.::.|...|.||          :.::..::.|||  .:|:||::::|....::||:|:
Worm     2 GKNSTKPTSKANSSPEGKAMSPMKTQLLDDQQTPS--SSSSKRKNLRKPSTDDTPSSSE------ 58

  Fly   351 GNGQRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESED 415
                    |.|..:| ::.:|...|..::::|:  |:.|.:|           |...|...|.:.
Worm    59 --------PLSKKNR-LDSTETAEEDNTRRRRT--LKHGEVA-----------LPVCSFCKEDQK 101

  Fly   416 EDDEDDDRNRNGDDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYD------EEEDYDTDR 474
            .||                                 |...:.||...:|.      .:|::.|
Worm   102 ADD---------------------------------EPLKECSECKAKYHIRKCLRYKEEFAT-- 131

  Fly   475 STIREKNVFESGKQSCAKLSTGDG----LGSPQNNEL--------GS-------------ENWGF 514
                  |:.:..|..|.:....|.    :|.|.|.|.        ||             .:|..
Worm   132 ------NILKLNKWFCPRCVECDSCKGYIGDPSNIECTFCCRAWHGSCAPKGYSPSGEFDSDWYC 190

  Fly   515 AAVAKNPIDIFVKSKHNSNVKGIGYSKPAASTFATSPAANRVQKSTPVASSTPEKNSAPIGGMTI 579
            .|..:              ||||       ..:.|:..::|...|.||.....::     ||...
Worm   191 IACCR--------------VKGI-------KIWHTTSISHRSHPSAPVKERKTKR-----GGAAR 229

  Fly   580 KRQTA-NGQ--------KKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRET 635
            |.:.. .|.        .|:.:..:.:..|||.|.:|   .:||.
Worm   230 KDELEFEGDIDELKDLLAKRDLTFEILNYEAGFSSKK---PLPYT-------------------- 271

  Fly   636 HSQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQ--MSNNHIEKV 698
             ..:.||:.....:.:|.......:..|..|..|.|...|:||::....:|..|  :.|.|.|
Worm   272 -PTSSGKKNKKKQQKSPVREEFDYSNAERSPDFPKVVRADLELFKATKSEAYQQTPIFNPHPE-- 333

  Fly   699 NDVSLKSGQ-----NTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDR 758
                   ||     ..::.|:|          |||.:.:.......|:.|:|||..|..:..|..
Worm   334 -------GQFLHFGTGKACKAI----------YSSAYEEPLHSSAHLYACKFCLHTTNLKEDLIV 381

  Fly   759 HQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTK 823
            |.:.|..|.||||||:|...::.|||||.|.|.|||:|||::|.|:..||||.:||.|.||:|.:
Worm   382 HWDICNAKHPPGTEIYRNDGLAFFEVDGAVQKKYCQDLCLISKLFIASKTLYDEVETFKFYVLCE 446

  Fly   824 NDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSD 888
            ....|..:||||||||:.::..|:||:|.:|..|:.||||.|||.||.|||.|.::|.||.||||
Worm   447 ITTEGYVIVGYFSKEKNPSKNNNLSCLLVLPMVQKMGYGRLLIDMSYELSRLEMRIGHPEHPLSD 511

  Fly   889 LGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQ 953
            ||.|:|..||:|.:|.|:.:||||.::..||:.:.|.:|..||.....|.|.|.|:   |.: |.
Worm   512 LGILAYRGYWRSSLLCYIREHRNYDRLNIKDMCLATRIAPVDIVNQLMLDNMIVLK---GGV-YS 572

  Fly   954 INVKIEWKKVLAHHNKMANSK-TRIIIEPDCLRWSPLLSVSKL 995
            |.:   .|:.|    |...|: .|..::|..|.|.|..|..:|
Worm   573 IKI---GKRAL----KFPLSQCRRRFVDPSQLFWKPKPSAERL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	116/276 (42%)
		MOZ_SAS	768..947	CDD:280097	90/178 (51%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
mys-4	NP_492265.1	PLN00058	35..117	CDD:177689	26/144 (18%)
		PHD	92..144	CDD:214584	13/92 (14%)
		PHD	147..193	CDD:214584	8/45 (18%)
		NAT_SF	347..603	CDD:302625	116/276 (42%)
		MOZ_SAS	391..565	CDD:280097	88/173 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3624
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820