DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and mys-1

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_504796.1	Gene:	mys-1 / 179096	WormBaseID:	WBGene00007029	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	164/466 - (35%)
Similarity:	236/466 - (50%)	Gaps:	89/466 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   588 KKKIVP------LKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLEE-----IERSRETHS---- 637
            ||:|:.      .|.:|.:. :.|||..:....|    ||.....||     |.|.|..:.
Worm     5 KKEIIEDENHGISKKIPTDP-RQYEKVTEGCRLL----VMMASQEEERWAEVISRCRAANGSIKF 64

  Fly   638 ---------------QAD-------------GK-----REMNNDEDAPGESTKRANPFENQPLPP 669
                           |:|             ||     ||.|.|.:.  ...|::......||.|
Worm    65 YVHYIDCNRRLDEWVQSDRLNLASCELPKKGGKKGAHLREENRDSNE--NEGKKSGRKRKIPLLP 127

  Fly   670 --GVTATDVELYQEVL------------HKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKW 720
              .:.|..|:..|.:.            ..::|..|.:.:.::.:|           :.|::|:.
Worm   128 MDDLKAESVDPLQAISTMTSGSTPSLRGSMSMVGHSEDAMTRIRNV-----------ECIELGRS 181

  Fly   721 DIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVD 785
            .|:.||.:|:||:...|..:::|||||||.||::.|.||..||....|||.:|:....:|.||:|
Worm   182 RIQPWYFAPYPQQLTSLDCIYICEFCLKYLKSKTCLKRHMEKCAMCHPPGNQIYSHDKLSFFEID 246

  Fly   786 GNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCI 850
            |..||.|.||||||||.||||||||||.:|||||:||:.|:.|.|:||||||||...::|||:||
Worm   247 GRKNKSYAQNLCLLAKLFLDHKTLYYDTDPFLFYVLTEEDEKGHHIVGYFSKEKESAEEYNVACI 311

  Fly   851 LTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLE--YLYKHRNYT 913
            |.:|.:|::|||..||:|||.||:.|.:.|:|||||||||.|||.|||...:::  :.:|.|:..
Worm   312 LVLPPFQKKGYGSLLIEFSYELSKIEQKTGSPEKPLSDLGLLSYRSYWSMAIMKELFAFKRRHPG 376

  Fly   914 K-ITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRI 977
            : ||.:||:..|.:...|:....:.|:..|..|..    |.|.:..|.::|.....:.|..|||
Worm   377 EDITVQDISQSTSIKREDVVSTLQQLDLYKYYKGS----YIIVISDEKRQVYEKRIEAAKKKTR- 436

  Fly   978 IIEPDCLRWSP 988
             |.|..|:|.|
Worm   437 -INPAALQWRP 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	130/279 (47%)
		MOZ_SAS	768..947	CDD:280097	94/181 (52%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
mys-1	NP_504796.1	Tudor-knot	30..86	CDD:288553	10/59 (17%)
		SAS2	45..444	CDD:227360	151/417 (36%)
		NAT_SF	168..446	CDD:302625	130/294 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820