DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enok and mys-2

DIOPT Version :9

Sequence 1:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster
Sequence 2:	NP_001309531.1	Gene:	mys-2 / 173281	WormBaseID:	WBGene00010537	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	430	Identity:	143/430 - (33%)
Similarity:	230/430 - (53%)	Gaps:	63/430 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 YLTEE----TVMKVQLL----------EEIE----RSRETHSQADGKREM-----------NNDE 649
            |:.|:    ||.||..:          :|:.    :|.|.|.|  |.:|:           .|||
Worm    40 YMVEKFIINTVKKVVAVIIHIDFRKPPQEVRTNNYKSIENHEQ--GAKELMYYVHYEELDRRNDE 102

  Fly   650 DAPGESTKRANPFENQPLPPGVTATDVE-LYQE-VLHKAVVQMSN-------------NHIE-KV 698
            ....:.. ..|....:|:....|...|| |::| |:...|::.|.             :|:: .:
Worm   103 WITLDKI-LVNEVVVEPVIKVPTKAPVEDLHKEIVVGPPVIKPSGALTRSQRRTLEEYSHLKTDL 166

  Fly   699 NDVSLKSGQ---------NTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRS 754
            ||:...:.:         ..::...|.||..:|..||.||||.: ...|.:::||:||.||....
Worm   167 NDLDATTARLEREHEERTKVKNIPQITIGAHEILAWYYSPFPPD-CENLDIYMCEYCLLYTPHHE 230

  Fly   755 VLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFY 819
            ...:|.:.|..:||||.||:|:.::||:||||:..|:|||.||||:|.|:||||||:||:.|:||
Worm   231 RFKQHIDTCKVRQPPGNEIYRKDHLSVYEVDGSGQKLYCQCLCLLSKLFMDHKTLYFDVDDFMFY 295

  Fly   820 ILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEK 884
            :|.:.|:.|.|:|||||:|.....  |::||:..|.:|::|||:.||.|||.|||.||.:|.|||
Worm   296 VLCETDEHGAHIVGYFSREVESAN--NLACIMVFPPFQKKGYGKLLIQFSYELSRREGYIGMPEK 358

  Fly   885 PLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGD 949
            ||||||::||.|||...:::..:.|:.:| :|...::.::|:|:.||......:...:..|....
Worm   359 PLSDLGKVSYRSYWWWRLMKLFHIHQGHT-VTATFLSNESGIAVDDIVSTLITMRMCRQYKEPEF 422

  Fly   950 IRYQINVKIEWKKVLAHHNKMANSK-TRIIIEPDCLRWSP 988
            |..:..|:|. :|::.|.......| .|::::...:||:|
Worm   423 IPGEWYVRIH-RKIVDHCVMCGYGKPPRLLLDRTKVRWAP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584
		NAT_SF	713..989	CDD:302625	114/277 (41%)
		MOZ_SAS	768..947	CDD:280097	84/178 (47%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
mys-2	NP_001309531.1	Tudor-knot	53..110	CDD:288553	11/59 (19%)
		NAT_SF	170..418	CDD:302625	103/251 (41%)
		MOZ_SAS	244..418	CDD:280097	83/176 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820