Protein Alignment enok and kat6a

DIOPT Version :9

• Sequence 1: NP_001286823.1
• Gene: enok / 37859
• FlyBaseID: FBgn0034975
• Length: 2291
• Species: Drosophila melanogaster
• Sequence 2: XP_031755179.1
• Gene: kat6a / 100496520
• XenbaseID: XB-GENE-6076141
• Length: 1904
• Species: Xenopus tropicalis
• Alignment Length: 2491
• Identity: 612/2491 - (24%)
• Similarity: 930/2491 - (37%)
• Gaps: 833/2491 - (33%)

  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :.|||||||.|::.||||||.:|:|.|:.|.|......|.|:||.:|:.|.|:||.|||.:|||.
 Frog     9 YTQWILEAIRKVKKQKQRPSEERLCNAVSTSHGLDRHTVLEQLELSVKDGTVLKVTNKGQNSYKD 73

  Fly    79 PMAKRRVKVDKNT---------NLYKLVAKAVHDLGECEGSTIKSIENYIQKFNCIDLS------ 128
            |....|:.:.|.|         :.::|:.:|:..|.|..||::||||.:::....:..|
 Frog    74 PDNPGRLALPKATKNQGRPEGLDWHRLLKRALESLEEPGGSSLKSIERFLRSQRDVSASFGGNTG 138

  Fly   129 PNVDFKAVIKASIKKAVDAGFLIQEGKLYK------KGKS------------LTTPRKCAPVSEV 175
            .:..|...::.::|:|:..|.:.:||.||:      :||.            |....|..||:|.
 Frog   139 ASSAFHQQLRLAVKRALAHGRINKEGSLYQLNAKLAEGKQGWESLASLPPVCLLPHEKDKPVAEP 203

  Fly   176 VIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYMLVTKGTIW 240
            :    ..|:.|.|..:.|....||.|.||..||.|.|.:|...:.....:         .|...|
 Frog   204 I----PICSFCLGTKESNREKKPEELISCADCGNSGHPSCLKFSPELTVR---------VKALRW 255

  Fly   241 DCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQGFDTPKL 302
            .|..|..|:.|:.:.: ...:|.|..|...||:.|.:....:.||..:.|:.|  .|:|   .||
 Frog   256 QCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCEPPLTRMPKGMWICQICRPRKKG---RKL 317

  Fly   303 VKKDNSRIKMEAERMTPSYKYASNKRQSIKKDGNIESPSTSKLCVYNDGNGQRRKVPASLSSRKM 367
            :.|..::|:   .|.|.......|:   :||..:..:||..|      |.|
 Frog   318 LHKKAAQIR---RRYTNPIGRPKNR---LKKQSSTTNPSFGK------GRG-------------- 356

  Fly   368 NHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESEDEDDEDDDRNRNGDDNDQ 432
                                    |....|||..| :.||||          |||  |:.||:
 Frog   357 ------------------------APGRGRKRKLS-MCSTSS----------DDD--RSSDDH-- 382

  Fly   433 DESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTGD 497
                                                                          .|.
 Frog   383 --------------------------------------------------------------RGC 385

  Fly   498 GLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGI--GYSKPAASTFATSPAANRVQKST 560
            |...|                           .|...||:  |.:|    .|..||
 Frog   386 GTSVP---------------------------FNKKTKGLIDGLTK----FFTPSP--------- 410

  Fly   561 PVASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQL 625
                                    :|:|.:                  .:.:.|
 Frog   411 ------------------------DGRKAR------------------AEALDY----------- 422

  Fly   626 LEEIERSRETHSQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQM 690
              .::|||:...:..|:.:.:|.|   |...|    .:.:..|..::..::.|:|::..:|
 Frog   423 --SLQRSRKRGPRKSGQADWDNQE---GWDCK----LDGEDHPGMISEKEIALFQDIQEQA---- 474

  Fly   691 SNNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSV 755
                ::||. |........:.|..|:.||::|:||||||:||||.||.||:||||||:|.|||::
 Frog   475 ----LQKVG-VCGPPDPQVRCPSVIEFGKYEIQTWYSSPYPQEYTRLPKLYLCEFCLRYMKSRTM 534

  Fly   756 LDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYI 820
            |.:|..||.|..||..||:|:.|:|||||||.|:.|||||||||||.|||||||||||||||||:
 Frog   535 LQQHTKKCNWFHPPANEIYRKDNLSVFEVDGKVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYV 599

  Fly   821 LTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKP 885
            ||:||..||||||||||||||.||||||||:.:|||||:||||||||||||||:.|||.|:||||
 Frog   600 LTQNDSKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKP 664

  Fly   886 LSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDI 950
            |||||||||.:||||||||.|:.:|.: :::.|.:...||:...|||.....|..::||   ||
 Frog   665 LSDLGRLSYMAYWKSVVLECLHHNREH-QLSIKRLTKLTGICPQDIAATLHQLRMLELR---GD- 724

  Fly   951 RYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSVSKLPNIIKPISNREYLSNQMETN 1015
             ..:.|:.| :::..|.:::......:.::|:.|||:|::..:.:            :|::.|..
 Frog   725 -RVVLVRRE-QQIQTHMSRLQARPREVEVDPEALRWTPVIVTNSV------------VSDEEEAE 775

  Fly  1016 SSFKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEKLIDERENQRKRAYPEEFLKSA--- 1077
            |   |..||                |..|...:.|.|     :.:...|..|:...||.:..
 Frog   776 S---EEEED----------------EEEEEDEEQRSP-----LKDNSQQVLRSISREFERETCPV 816

  Fly  1078 -SNEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKDLSEQLTKRAQRLAKRNDLIPHTNKRKHFD 1141
             ..|...|.|....||....:..:|.|.  .:.|...:.|...|.:|           .:|....
 Frog   817 LEKEKSPPTLRPSSPNSRFPNPRQLQDL--LRDSLPANSQPPGRGRR-----------GRRGRRG 868

  Fly  1142 RPLENNTTSTD------HNPPA----QSQADTAGTENGH---------KSEETAAKENCKNVVEK 1187
            |...:::.:.|      ..||.    ..:...:|:..|.         :.:....:|......|.
 Frog   869 RGFGSSSRAADLLRLLAREPPGPPRRNGERGRSGSRRGRLKRLADPMLRRDFLEQQERLAQRFES 933

  Fly  1188 EHVDKPVNIMPKLRGKQSNGKRSEEPQFNENPTSDPVAVASLSPAKEITREPVKVAKTESPG--- 1249
            ||        |:||....:.:..:|.:..||.     ::.|.||  .|..:|  ..|.:.||
 Frog   934 EH--------PQLRRFSESSEEEDEDEEEENH-----SLRSDSP--PILTKP--TLKRKKPGAHR 981

  Fly  1250 -------KNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSEEKPMAIAQEP 1307
                   |:..::....|..|.:.||||..        |.|           :..|:.|     |
 Frog   982 RRRVRRRKHHHNSSVVTETISETTQVLDEP--------FDD-----------SDSERQM-----P 1022

  Fly  1308 KESPTEAGIKETKPLEVPEQKAKAKSPEK-PATVAETVLQHVHAPVNTEKISTEE---SKLELDV 1368
            :..|.|.|.....|.          ||.. |......:|:| :.|:...:.:||:   |.::..|
 Frog  1023 RLEPEEEGSGRDTPF----------SPSYFPYLTPYPLLRH-NRPLGKSRSNTEQAQGSAVQPTV 1076

  Fly  1369 HYLKLS------PDSALNP--------PVASVQKPV-----------------PEPPAP------ 1396
            ..::.:      |||. ||        |....:||:                 |.||.|
 Frog  1077 SSMRSTEGSASLPDSC-NPAPVKKKGWPKGKSRKPLHWKKRPGRKPGFKLNREPPPPVPTSPPPA 1140

  Fly  1397 -------------KEKAKDLQAAQPSEALQKQPEIEMVKK-TETKTETPVSN---PPSNRTDVSS 1444
                         :|:.::.:..:.....:|:||.|:|:. ||...|...:|   .||:.::.||
 Frog  1141 RPGRKSRTREEEEEEEEEEEEPTREESPERKEPEKEIVETVTEKAAEEEPTNTVVQPSSPSESSS 1205

  Fly  1445 LVE---QPVKAAPEKVEQPMV--KEAVDIKDKALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHE 1504
            ..|   :.|:..|...|.|:.  :|...:.::|.::.....|..|||.|:.
 Frog  1206 CSESSSREVENHPASPEMPVQTGEEPQAVTEEAEQEEEERTPEEKPETTTV-------------- 1256

  Fly  1505 KEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFPLNQMPNYHTSQY 1569
                 ::||..|..::|...|:              :..|..:|:..:..:.|..|.|..
 Frog  1257 -----SNQQEDQDADDEDEGAK--------------EAEEGEELEPELVPEEPAPQEPCV----- 1297

  Fly  1570 WQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQ------MHQT 1628
                     :|..:...||.                           ..|.|...      :.:.
 Frog  1298 ---------VSSSEEDDKGD---------------------------GAQEATEGPDPPSCLEEA 1326

  Fly  1629 KE-KHKVERKNSGKKEEQNKVV-------SSVNVV-------STAREDAHVQHCNEYAANNQAAL 1678
            :| :.|||.:...::||..:|:       .:|..|       |:.|:|.....|.:   ....|.
 Frog  1327 EECQEKVEEEQKEEEEEAEEVIPHTELDLETVQAVQSLTQEESSERDDGTYGDCED---ETLTAC 1388

  Fly  1679 YNQKCASQQKQAQQMKSLANVQNPVPRQSNSNAPESTV-LMPNPVISQAGSVPAKQKVEHGVNST 1742
            ...:..:|.::..|: ||:...:|    |..::|.|:| ..|:..:..|.|....|.:|:  |.|
 Frog  1389 QTLQSFTQAEEDPQL-SLSEECHP----SAHDSPISSVHSHPSQSVRSASSPSVPQTMEN--NGT 1446

  Fly  1743 SV---ISRE-GKLNKIGHSNIHAT---------AQHANLQVGGGQSDVNPNMVYNTESSANSAMQ 1794
            .|   ||.: |.|:.....|:..|         :.|:...|..|.||:         .|..|..:
 Frog  1447 GVYPQISPDAGSLSAPSIQNLETTSPMMDVPSVSDHSQQVVDSGFSDL---------GSIESTTE 1502

  Fly  1795 HYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHMSIQNS 1859
            :|          ::|::..|::..|  .||:.|:            ||..:            ||
 Frog  1503 NY----------ENPSSYDSSMGGG--SISSQSS------------CSYAS------------NS 1531

  Fly  1860 HMQQQNNL--NLNLAPEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIRSGNT 1922
            :......|  ..::|..|.:     .|.|....:..|......::.||........|.   |.|.
 Frog  1532 NANGGGGLPSTASMAQNGCA-----VNQQMASMASMLQPSQACSIKSPQSCASERPPS---SSNN 1588

  Fly  1923 QQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQ 1987
            .|.......||..........||                         ||  ||    |:.|.|.
 Frog  1589 NQPPPPPPPPPPLPPQQPQPPPQ-------------------------QQ--QP----PMSQCSM 1622

  Fly  1988 NFSANPSNYDIVGMPAVIQQRMSLNGSVHSL------ANSHQRIEQPSSACAV-------NNFYL 2039
            |.|..||       |.:::.....|||..|:      |..:   .|||:..::       |....
 Frog  1623 NNSFGPS-------PMIMEIPDQSNGSNLSIYPGDFGAGGY---TQPSATFSLAKLQQLTNTIMD 1677

  Fly  2040 QNNMPAAENAPRVPVSSSLGGPPTAGNNDQRQAGQDSITTANSSGATASLAGNLCSLSKLQQLTN 2104
            .:.||.: :||.|                          |:.::..:.|.||       |.|||:
 Frog  1678 PHAMPYS-HAPAV--------------------------TSYANSVSLSNAG-------LPQLTS 1708

  Fly  2105 CLESQPCNTSPGAQVNLAPSPHHPIPPNSTPPPHLLMQNRNISTPPNMLQTQVTPLQYKYYPGNM 2169
               |.|...:|.||..:            ||||.:           |:||..::       .||:
 Frog  1709 ---SHPLTGAPQAQATM------------TPPPTM-----------NLLQCNMS-------AGNL 1740

  Fly  2170 NIP---------PITSAQNTSRNTRNTPSAPVQH------TSTPMGSGNNRTANVHISPNL---- 2215
            .||         |:....:....:...|:||..|      .|||....:.|..:|..|.|:
 Frog  1741 GIPHSQRIQSQMPVKGHISIRSKSAPLPAAPSPHQQQLYGRSTPGMQSSARALSVQRSMNMGVNL 1805

  Fly  2216 ----------MAPYGAINSYRMSPQQSPPTGSYSSGGDYPN--SQIPMQ----MMNMQSQYQDAC 2264
                      |.|..|:.|||||  |.....||.|...|.|  ||.|||    ||..|:..|..
 Frog  1806 MPTSPYNVNTMNPLNAMGSYRMS--QPMVNSSYHSNAAYMNQTSQYPMQVGMGMMGAQAYTQQP- 1867

  Fly  2265 VLQRGTPSNPMY--PTYSPYL 2283
             :|.....|.||  |.:..|:
 Frog  1868 -MQPNPHGNMMYTPPPHHSYM 1887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_001286823.1	H15	95..152	CDD:294056	15/62 (24%)
		PHD_SF	183..>215	CDD:304600	13/31 (42%)
		PHD	248..292	CDD:214584	11/44 (25%)
		NAT_SF	713..989	CDD:302625	165/275 (60%)
		MOZ_SAS	768..947	CDD:280097	123/178 (69%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064	92/480 (19%)
kat6a	XP_031755179.1	H15	100..160	CDD:197772	15/59 (25%)
		PHD1_MOZ_MORF	203..260	CDD:277090	17/69 (25%)
		PHD2_KAT6A_6B	262..308	CDD:277002	11/45 (24%)
		PLN00104	<486..760	CDD:215056	166/280 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1915
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1675
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3624
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.060