Protein Alignment enok and kat6a

DIOPT Version :10

• Sequence 1: NP_523838.1
• Gene: enok / 37859
• FlyBaseID: FBgn0034975
• Length: 2291
• Species: Drosophila melanogaster
• Sequence 2: XP_031755179.1
• Gene: kat6a / 100496520
• XenbaseID: XB-GENE-6076141
• Length: 1904
• Species: Xenopus tropicalis
• Alignment Length: 2489
• Identity: 613/2489 - (24%)
• Similarity: 931/2489 - (37%)
• Gaps: 829/2489 - (33%)

  Fly    14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
            :.|||||||.|::.||||||.:|:|.|:.|.|......|.|:||.:|:.|.|:||.|||.:|||.
 Frog     9 YTQWILEAIRKVKKQKQRPSEERLCNAVSTSHGLDRHTVLEQLELSVKDGTVLKVTNKGQNSYKD 73

  Fly    79 PMAKRRVKVDKNT---------NLYKLVAKAVHDLGECEGSTIKSIENYIQKFNCIDLS------ 128
            |....|:.:.|.|         :.::|:.:|:..|.|..||::||||.:::....:..|
 Frog    74 PDNPGRLALPKATKNQGRPEGLDWHRLLKRALESLEEPGGSSLKSIERFLRSQRDVSASFGGNTG 138

  Fly   129 PNVDFKAVIKASIKKAVDAGFLIQEGKLYK------KGKS------------LTTPRKCAPVSEV 175
            .:..|...::.::|:|:..|.:.:||.||:      :||.            |....|..||:|.
 Frog   139 ASSAFHQQLRLAVKRALAHGRINKEGSLYQLNAKLAEGKQGWESLASLPPVCLLPHEKDKPVAEP 203

  Fly   176 VIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYMLVTKGTIW 240
            :    ..|:.|.|..:.|....||.|.||..||.|.|.:|...:.....:         .|...|
 Frog   204 I----PICSFCLGTKESNREKKPEELISCADCGNSGHPSCLKFSPELTVR---------VKALRW 255

  Fly   241 DCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQGFDTPKL 302
            .|..|..|:.|:.:.: ...:|.|..|...||:.|.:....:.||..:.|:.|  .|:|   .||
 Frog   256 QCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCEPPLTRMPKGMWICQICRPRKKG---RKL 317

  Fly   303 VKKDNSRIKMEAERMTPSYKYASNKRQSIKKDGNIESPSTSKLCVYNDGNGQRRKVPASLSSRKM 367
            :.|..::|:   .|.|.......|:   :||..:..:||..|      |.|
 Frog   318 LHKKAAQIR---RRYTNPIGRPKNR---LKKQSSTTNPSFGK------GRG-------------- 356

  Fly   368 NHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESEDEDDEDDDRNRNGDDNDQ 432
                                    |....|||..| :.||||          |||  |:.||:
 Frog   357 ------------------------APGRGRKRKLS-MCSTSS----------DDD--RSSDDH-- 382

  Fly   433 DESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTGD 497
                                                                          .|.
 Frog   383 --------------------------------------------------------------RGC 385

  Fly   498 GLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGIGYSKPAASTFATSPAANRVQKSTPV 562
            |...|.|.:           .|..||              |.:|    .|..||
 Frog   386 GTSVPFNKK-----------TKGLID--------------GLTK----FFTPSP----------- 410

  Fly   563 ASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLE 627
                                  :|:|.:                  .:.:.|
 Frog   411 ----------------------DGRKAR------------------AEALDY------------- 422

  Fly   628 EIERSRETHSQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQMSN 692
            .::|||:...:..|:.:.:|.|   |...|    .:.:..|..::..::.|:|::..:|
 Frog   423 SLQRSRKRGPRKSGQADWDNQE---GWDCK----LDGEDHPGMISEKEIALFQDIQEQA------ 474

  Fly   693 NHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLD 757
              ::||. |........:.|..|:.||::|:||||||:||||.||.||:||||||:|.|||::|.
 Frog   475 --LQKVG-VCGPPDPQVRCPSVIEFGKYEIQTWYSSPYPQEYTRLPKLYLCEFCLRYMKSRTMLQ 536

  Fly   758 RHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILT 822
            :|..||.|..||..||:|:.|:|||||||.|:.|||||||||||.|||||||||||||||||:||
 Frog   537 QHTKKCNWFHPPANEIYRKDNLSVFEVDGKVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLT 601

  Fly   823 KNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLS 887
            :||..||||||||||||||.||||||||:.:|||||:||||||||||||||:.|||.|:||||||
 Frog   602 QNDSKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLS 666

  Fly   888 DLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRY 952
            |||||||.:||||||||.|:.:|.: :::.|.:...||:...|||.....|..::||   ||  .
 Frog   667 DLGRLSYMAYWKSVVLECLHHNREH-QLSIKRLTKLTGICPQDIAATLHQLRMLELR---GD--R 725

  Fly   953 QINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSVSKLPNIIKPISNREYLSNQMETNSS 1017
            .:.|:.| :::..|.:::......:.::|:.|||:|::..:.:            :|::.|..|
 Frog   726 VVLVRRE-QQIQTHMSRLQARPREVEVDPEALRWTPVIVTNSV------------VSDEEEAES- 776

  Fly  1018 FKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEKLIDERENQRKRAYPEEFLKSA----S 1078
              |..||                |..|...:.|.|     :.:...|..|:...||.:..    .
 Frog   777 --EEEED----------------EEEEEDEEQRSP-----LKDNSQQVLRSISREFERETCPVLE 818

  Fly  1079 NEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKDLSEQLTKRAQRLAKRNDLIPHTNKRKHFDRP 1143
            .|...|.|....||....:..:|.|.  .:.|...:.|...|.:|           .:|....|.
 Frog   819 KEKSPPTLRPSSPNSRFPNPRQLQDL--LRDSLPANSQPPGRGRR-----------GRRGRRGRG 870

  Fly  1144 LENNTTSTD------HNPPA----QSQADTAGTENGH---------KSEETAAKENCKNVVEKEH 1189
            ..:::.:.|      ..||.    ..:...:|:..|.         :.:....:|......|.||
 Frog   871 FGSSSRAADLLRLLAREPPGPPRRNGERGRSGSRRGRLKRLADPMLRRDFLEQQERLAQRFESEH 935

  Fly  1190 VDKPVNIMPKLRGKQSNGKRSEEPQFNENPTSDPVAVASLSPAKEITREPVKVAKTESPG----- 1249
                    |:||....:.:..:|.:..||.     ::.|.||  .|..:|  ..|.:.||
 Frog   936 --------PQLRRFSESSEEEDEDEEEENH-----SLRSDSP--PILTKP--TLKRKKPGAHRRR 983

  Fly  1250 -----KNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSEEKPMAIAQEPKE 1309
                 |:..::....|..|.:.||||..        |.|           :..|:.|     |:.
 Frog   984 RVRRRKHHHNSSVVTETISETTQVLDEP--------FDD-----------SDSERQM-----PRL 1024

  Fly  1310 SPTEAGIKETKPLEVPEQKAKAKSPEK-PATVAETVLQHVHAPVNTEKISTEE---SKLELDVHY 1370
            .|.|.|.....|.          ||.. |......:|:| :.|:...:.:||:   |.::..|..
 Frog  1025 EPEEEGSGRDTPF----------SPSYFPYLTPYPLLRH-NRPLGKSRSNTEQAQGSAVQPTVSS 1078

  Fly  1371 LKLS------PDSALNP--------PVASVQKPV-----------------PEPPAP-------- 1396
            ::.:      |||. ||        |....:||:                 |.||.|
 Frog  1079 MRSTEGSASLPDSC-NPAPVKKKGWPKGKSRKPLHWKKRPGRKPGFKLNREPPPPVPTSPPPARP 1142

  Fly  1397 -----------KEKAKDLQAAQPSEALQKQPEIEMVKK-TETKTETPVSN---PPSNRTDVSSLV 1446
                       :|:.::.:..:.....:|:||.|:|:. ||...|...:|   .||:.::.||..
 Frog  1143 GRKSRTREEEEEEEEEEEEPTREESPERKEPEKEIVETVTEKAAEEEPTNTVVQPSSPSESSSCS 1207

  Fly  1447 E---QPVKAAPEKVEQPMV--KEAVDIKDKALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHEKE 1506
            |   :.|:..|...|.|:.  :|...:.::|.::.....|..|||.|:.
 Frog  1208 ESSSREVENHPASPEMPVQTGEEPQAVTEEAEQEEEERTPEEKPETTTV---------------- 1256

  Fly  1507 AIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFPLNQMPNYHTSQYWQ 1571
               ::||..|..::|...|:              :..|..:|:..:..:.|..|.|..
 Frog  1257 ---SNQQEDQDADDEDEGAK--------------EAEEGEELEPELVPEEPAPQEPCV------- 1297

  Fly  1572 WEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQ------MHQTKE 1630
                   :|..:...||.                           ..|.|...      :.:.:|
 Frog  1298 -------VSSSEEDDKGD---------------------------GAQEATEGPDPPSCLEEAEE 1328

  Fly  1631 -KHKVERKNSGKKEEQNKVV-------SSVNVV-------STAREDAHVQHCNEYAANNQAALYN 1680
             :.|||.:...::||..:|:       .:|..|       |:.|:|.....|.:   ....|...
 Frog  1329 CQEKVEEEQKEEEEEAEEVIPHTELDLETVQAVQSLTQEESSERDDGTYGDCED---ETLTACQT 1390

  Fly  1681 QKCASQQKQAQQMKSLANVQNPVPRQSNSNAPESTV-LMPNPVISQAGSVPAKQKVEHGVNSTSV 1744
            .:..:|.::..|: ||:...:|    |..::|.|:| ..|:..:..|.|....|.:|:  |.|.|
 Frog  1391 LQSFTQAEEDPQL-SLSEECHP----SAHDSPISSVHSHPSQSVRSASSPSVPQTMEN--NGTGV 1448

  Fly  1745 ---ISRE-GKLNKIGHSNIHAT---------AQHANLQVGGGQSDVNPNMVYNTESSANSAMQHY 1796
               ||.: |.|:.....|:..|         :.|:...|..|.||:         .|..|..::|
 Frog  1449 YPQISPDAGSLSAPSIQNLETTSPMMDVPSVSDHSQQVVDSGFSDL---------GSIESTTENY 1504

  Fly  1797 DCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHMSIQNSHM 1861
                      ::|::..|::..|  .||:.|:            ||..:            ||:.
 Frog  1505 ----------ENPSSYDSSMGGG--SISSQSS------------CSYAS------------NSNA 1533

  Fly  1862 QQQNNL--NLNLAPEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIRSGNTQQ 1924
            .....|  ..::|..|.:     .|.|....:..|......::.||........|.   |.|..|
 Frog  1534 NGGGGLPSTASMAQNGCA-----VNQQMASMASMLQPSQACSIKSPQSCASERPPS---SSNNNQ 1590

  Fly  1925 RDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQNF 1989
            .......||..........||                         ||  ||    |:.|.|.|.
 Frog  1591 PPPPPPPPPPLPPQQPQPPPQ-------------------------QQ--QP----PMSQCSMNN 1624

  Fly  1990 SANPSNYDIVGMPAVIQQRMSLNGSVHSL------ANSHQRIEQPSSACAV-------NNFYLQN 2041
            |..||       |.:::.....|||..|:      |..:   .|||:..::       |.....:
 Frog  1625 SFGPS-------PMIMEIPDQSNGSNLSIYPGDFGAGGY---TQPSATFSLAKLQQLTNTIMDPH 1679

  Fly  2042 NMPAAENAPRVPVSSSLGGPPTAGNNDQRQAGQDSITTANSSGATASLAGNLCSLSKLQQLTNCL 2106
            .||.: :||.|                          |:.::..:.|.||       |.|||:
 Frog  1680 AMPYS-HAPAV--------------------------TSYANSVSLSNAG-------LPQLTS-- 1708

  Fly  2107 ESQPCNTSPGAQVNLAPSPHHPIPPNSTPPPHLLMQNRNISTPPNMLQTQVTPLQYKYYPGNMNI 2171
             |.|...:|.||..:            ||||.:           |:||..::       .||:.|
 Frog  1709 -SHPLTGAPQAQATM------------TPPPTM-----------NLLQCNMS-------AGNLGI 1742

  Fly  2172 P---------PITSAQNTSRNTRNTPSAPVQH------TSTPMGSGNNRTANVHISPNL------ 2215
            |         |:....:....:...|:||..|      .|||....:.|..:|..|.|:
 Frog  1743 PHSQRIQSQMPVKGHISIRSKSAPLPAAPSPHQQQLYGRSTPGMQSSARALSVQRSMNMGVNLMP 1807

  Fly  2216 --------MAPYGAINSYRMSPQQSPPTGSYSSGGDYPN--SQIPMQ----MMNMQSQYQDACVL 2266
                    |.|..|:.|||||  |.....||.|...|.|  ||.|||    ||..|:..|..  :
 Frog  1808 TSPYNVNTMNPLNAMGSYRMS--QPMVNSSYHSNAAYMNQTSQYPMQVGMGMMGAQAYTQQP--M 1868

  Fly  2267 QRGTPSNPMY--PTYSPYL 2283
            |.....|.||  |.:..|:
 Frog  1869 QPNPHGNMMYTPPPHHSYM 1887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
enok	NP_523838.1	PHD_SF	183..>215	CDD:473978	13/31 (42%)
		PHD	248..292	CDD:214584	11/44 (25%)
		PLN00104	<714..989	CDD:215056	165/274 (60%)
		PspC_subgroup_1	<1171..>1440	CDD:468201	68/336 (20%)
		PRK10263	<1206..>1736	CDD:236669	117/624 (19%)
kat6a	XP_031755179.1	H15	100..160	CDD:197772	15/59 (25%)
		PHD1_MOZ_MORF	203..260	CDD:277090	17/69 (25%)
		PHD2_KAT6A_6B	262..308	CDD:277002	11/45 (24%)
		PLN00104	<486..760	CDD:215056	166/280 (59%)
		PABP-1234	<1746..1875	CDD:130689	36/132 (27%)