DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and CDC42BPB

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_005268284.1	Gene:	CDC42BPB / 9578	HGNCID:	1738	Length:	1728	Species:	Homo sapiens

Alignment Length:	1749	Identity:	736/1749 - (42%)
Similarity:	1048/1749 - (59%)	Gaps:	246/1749 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |.|.||..|:.:|    .|..|..|       ...|::.|||..:.||.|||:|:|||:|.|::|
Human     2 SAKVRLKKLEQLL----LDGPWRNE-------SALSVETLLDVLVCLYTECSHSALRRDKYVAEF 55

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            |:.:|||..:|::::|.|:||:|:|:|||||||||.||:|.:||::|||||||||||||||||||
Human    56 LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||.||.||||.|||||||..:||||||||.||||||||||||||||||||:|||.||:
Human   121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:||||:.||||||||||||||..||:|||||||||:::.||||||:||||||||||||||:|
Human   186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 250

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSET 339
            ||||.|:||.||||||||||||||||||||||||||||||||||||:..|..||..|   .|||.
Human   251 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVT---DVSEE 312

  Fly   340 SQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDV 404
            ::||:.:|||..|.|||||||:||..|.:|.|::|:|||...|||:|:||||:|||||||||:.:
Human   313 AKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVL 377

  Fly   405 RLTDSIPPSANPAFSGFHLPFIGFTF-------------SLTSSSTLD----------------- 439
            |.|:.:||.::..|||.|||||||||             |:..|:||.
Human   378 RNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEA 442

  Fly   440 ---------------SKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALK 489
                           |:|.|.|   ..|:.::.....|:..||..:      ::|.||:::..||
Human   443 YERRIRRLEQEKLELSRKLQES---TQTVQSLHGSSRALSNSNRDK------EIKKLNEEIERLK 498

  Fly   490 -----------------------------------------QEKAELSKQHNEVFERLKTQDSEL 513
                                                     |||.||.||..|..||||:|..||
Human   499 NKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKEL 563

  Fly   514 QDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRE 578
            :||..||.:|:.|:||:.|:::|||.||||:|||:||||||::.|.||.|::|.|:|:::|.|:|
Human   564 KDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKE 628

  Fly   579 LELHIEDAVIEAAKEKKLREHAEDCCRQLQMEL-----RKGSSSVETTMPLSISSEMSSY--EIE 636
            ||..::|||.||:||:|||||:|:.|:|::.||     ::|......|  |....|:|..  |:|
Human   629 LEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGAT--LEHQQEISKIKSELE 691

  Fly   637 RLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLL 701
            :..|.:.|:|..::..|.:|::.::::..:.|:..|||.||:...:::|:.::.|...:..|.:.
Human   692 KKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVG 756

  Fly   702 ELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAE----DDEIFKELRMKREAITLWERQMAE 762
            .:|.:::.|::..|:|.::|::|.......:.:|.|:    :||: ::|..|:|::..||.|:||
Human   757 TIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDEL-QDLAAKKESVAHWEAQIAE 820

  Fly   763 IIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSAL 827
            |||||||||||||||||||:|||||||.|:. .:..:..:| ..|:.|||||||....|.|||||
Human   821 IIQWVSDEKDARGYLQALASKMTEELEALRS-SSLGSRTLD-PLWKVRRSQKLDMSARLELQSAL 883

  Fly   828 QREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQ--KKETE----------LRDLQ 880
            :.||:||.::.:||.:.:...::.:.:::|.:.:...:|.:.:  ||:.|          |.|.|
Human   884 EAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQ 948

  Fly   881 KGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYE 945
            ....||   |......|.|:   |||                        :...|..|.:|..:|
Human   949 DSIFEY---FNTAPLAHDLT---FRD------------------------SLSSSSASSLLAFWE 983

  Fly   946 PKYAGKNNKDHSSMKEA--SVSDLSREESDQLVKESQK----KVPGNTAI---------HQFLVR 995
            ...:....:..:...||  |:|..:.|:.:.:.:..|:    .:|...|:         |||.::
Human   984 ETSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIK 1048

  Fly   996 TFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGT 1060
            :|||||:|:|||||||||.|||..||:|.||||..|....|..||:|.:|:|||||:|..|||||
Human  1049 SFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGT 1113

  Fly  1061 AYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRE 1125
            ||:|:|||||...:|:||.|.:.||||.||||||:...:...|.|..|||||:||.||||.||..
Human  1114 AYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLA 1178

  Fly  1126 SDVIHAAKKDVPCIFKIKTALIDGGLSLNTLM-LADNESEKSKWVIALGELHRILKRNSLPNTAI 1189
            ||||||.::|:||||::..:|:......::|: |.:||:||.|||..|..|..||.:|.|.|..:
Human  1179 SDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWVGILEGLQSILHKNRLRNQVV 1243

  Fly  1190 FKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQ 1254
            ....|..|::|.||:..|.:.|:..::|.:|.|:||:.|.:.:..|.|..:.||:.|:.....|:
Human  1244 HVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPREK 1308

  Fly  1255 ILVILCGKQRNLRLLPIRALEASDVEW-IKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNH 1318
            |:::|||:..::.|.|..:|:.::..: ||:.|:|.|....|..::|  |......:|:||
Human  1309 IVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGCQLMATATLKR--NSGTCLFVAVKR---- 1367

  Fly  1319 TQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPEN 1383
             .|:.|||.||:..|:|..|.......|.|.:|.| ||.|.:.|||....::|:...::||:|.:
Human  1368 -LILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRD-RLCVGYPSGFCLLSIQGDGQPLNLVNPND 1430

  Fly  1384 QLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFC 1448
            ...|||:....||:..:|:      ...||||.|..:.:|||.|||::|.:|:|:||.|...:..
Human  1431 PSLAFLSQQSFDALCAVEL------ESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCS 1489

  Fly  1449 DGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKGLLQY 1513
            ..|:.|:|:..:|:|:.:|.||||:|||::..|||:.|.:.|.:. :.|.::|..:..:..:|..
Human  1490 PTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGTLNLLNC-EPPRLIYFKSKFSGAVLNV 1553

  Fly  1514 ---RDGNRKGL--PSIKRRFSIREINKTIKSDR-------------RSKMISAPTNFNHISHMGP 1560
               .|.::|.:  ...||||    :.|..:.:|             ||||||.||||||::||||
Human  1554 PDTSDNSKKQMLRTRSKRRF----VFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGP 1614

  Fly  1561 GDGIQNQRLLDLPTTLETADQACSPIIHSLSCIPQSRK-------SNFLEQVDANSDDY 1612
            |||:  |.|:|||                ||.:|.|::       :|...|..:.:..|
Human  1615 GDGM--QVLMDLP----------------LSAVPPSQEERPGPAPTNLARQPPSRNKPY 1655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	248/331 (75%)
		S_TKc	100..369	CDD:214567	210/268 (78%)
		KELK	478..556	CDD:292424	45/118 (38%)
		CEP63	492..749	CDD:293650	99/267 (37%)
		CEP63	652..880	CDD:293650	84/243 (35%)
		C1_1	990..1040	CDD:278556	30/49 (61%)
		PH_MRCK	1049..1182	CDD:269949	71/133 (53%)
		CNH	1211..1486	CDD:279162	93/275 (34%)
		CRIB	1544..1580	CDD:238077	22/35 (63%)
CDC42BPB	XP_005268284.1	STKc_MRCK_beta	3..411	CDD:270774	281/421 (67%)
		S_TKc	76..342	CDD:214567	210/268 (78%)
		TPH	426..786	CDD:290579	109/370 (29%)
		KELK	528..606	CDD:292424	40/77 (52%)
		DMPK_coil	878..939	CDD:117396	16/60 (27%)
		C1	1043..1092	CDD:237996	30/48 (63%)
		PH_MRCK	1102..1236	CDD:269949	71/133 (53%)
		CNH	1262..1527	CDD:279162	93/278 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143116
Domainoid	1	1.000	441	1.000	Domainoid score	I549
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1170	1.000	Inparanoid score	I202
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm42112
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840