DRSC/TRiP Functional Genomics Resources

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Protein Alignment gek and ROCK2

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:XP_005246247.1 Gene:ROCK2 / 9475 HGNCID:10252 Length:1417 Species:Homo sapiens


Alignment Length:1322 Identity:371/1322 - (28%)
Similarity:610/1322 - (46%) Gaps:327/1322 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            :::.|||....|..:....:||:.|.:.:||...:..|..:|.|::..:|:|::|:|||||||||
Human    42 NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV 106

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .:|:..:::||||||:|:|:||:||:::|.|.||||::.|.:..|:..|.|||||:..||:||:|
Human   107 QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEY 171

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            ..||||:.|:|.::  :||..||||..|::||:::||.:..:|||:||||:||||.||::|||||
Human   172 MPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG 234

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAES 309
            :|:::|:.|.|..:.|||||||||||:|:: :.|.|.||.||||||:||.:||||.|:|||||:|
Human   235 TCMKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS 298

  Fly   310 LVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID- 373
            ||.||.|||:|:|....|.    :.::|:.:::|:|..:...|.|||:||:::...||:|.... 
Human   299 LVGTYSKIMDHKNSLCFPE----DAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQW 359

  Fly   374 -WKNIRQGPAPYVPEVSSPTDTSNF-DVDDN--DVRLTDSIPPSANPAFSGFHLPFIGFTFSLTS 434
             |.|||:..||.|||:||..|:||| |::|:  ||. |..||    .||.|..|||||||:...:
Human   360 HWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVE-TFPIP----KAFVGNQLPFIGFTYYREN 419

  Fly   435 SSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQH 499
            ....||...:.:       |:|.|       ..|.|:.....:|..|.:.|:...|.|.||.::.
Human   420 LLLSDSPSCRET-------DSIQS-------RKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKC 470

  Fly   500 NEVFERLKTQDSELQDAIS------------QRNIAMMEY--SEVTEKLSELRNQKQKLSRQVRD 550
            ..|..||:....||::.|:            :|..|::::  :|...|.....::|:.|...|..
Human   471 KSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNS 535

  Fly   551 KEEELDGAMQKNDS---------------------LRNE------LRK----SDKTRRELE---- 580
            .:::|:...::|.:                     ||.|      |||    |.|..::||    
Human   536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 600

  Fly   581 -LHIEDAVIEAAK----------------EKKLREHAED--------CC---------------- 604
             |..::.::|.||                |::.|.|..:        .|                
Human   601 DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKV 665

  Fly   605 ----RQLQ-----MELRKGSSSVETTMPLSI----------------------------SSEMSS 632
                ||||     :|..|.:..::.|..|.:                            ..|..|
Human   666 ELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKS 730

  Fly   633 YEIERLELQFSEKLSHQQTRHNMELEA-------------LREQFSEL---------ENANLALT 675
            ..::.:|.:..|:.:.:|...|:.|||             .:::.:||         :..||.|.
Human   731 EAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLK 795

  Fly   676 KELQQTQER-LKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED 739
            .| |:||:| |....::..|....||...:||...|.:...|.|..|..:   .::..||.|..|
Human   796 IE-QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ---NAELRKERQDAD 856

  Fly   740 DEIFKELRMKREA----ITLWERQMAEI-----------------IQWVSDEKDA-RGYLQALAT 782
            .:: |||:.:.||    .||::.|:.|:                 .|.:.||:|: ...|:...|
Human   857 GQM-KELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLT 920

  Fly   783 KM-TEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDK-MELLNLQSALQREIQAKNMISDELSQTR 845
            |. :|:|.          ..:..:.:.:...:|:.| :|:..:.:..::|:..|:.....|.:|.
Human   921 KADSEQLA----------RSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETN 975

  Fly   846 SDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGG----LEYSESFLNKSTHHGLSSAFFRD 906
            ..|.|....:.:.|:..::.|.|.|::.:.|:|.:...    .::.:..|.:.|   |.:   :.
Human   976 RTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERT---LKT---QA 1034

  Fly   907 MSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREE 971
            ::|.:||::..|.             .:.||...:...|.    :|.|.|..:|.      .||:
Human  1035 VNKLAEIMNRKEP-------------VKRGNDTDVRRKEK----ENRKLHMELKS------EREK 1076

  Fly   972 -SDQLVK------ESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHT 1029
             :.|::|      |.|.::...:.|...|..|..|  |.:....|...|.           |.| 
Human  1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDS--KDSDIEQLRSQLQ-----------ALH- 1127

  Fly  1030 ICCQKVPTTCPVPMDQTKRPLGIDPT---RGIGTA----------YEGYVKVP-KSGVIKRGWIR 1080
                                :|:|.:   .|.|.|          .||::.:| ::...|.||::
Human  1128 --------------------IGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVK 1172

  Fly  1081 QFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTA 1145
            ::|:|...|:..||...|:   ...:...|||: |..|.|..|.::||..|..|::|.||:|   
Human  1173 KYVIVSSKKILFYDSEQDK---EQSNPYMVLDI-DKLFHVRPVTQTDVYRADAKEIPRIFQI--- 1230

  Fly  1146 LIDGGLSLNTLMLADNESEKSK 1167
                        |..||.|..|
Human  1231 ------------LYANEGESKK 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 171/336 (51%)
S_TKc 100..369 CDD:214567 138/268 (51%)
KELK 478..556 CDD:292424 20/91 (22%)
CEP63 492..749 CDD:293650 80/406 (20%)
CEP63 652..880 CDD:293650 61/274 (22%)
C1_1 990..1040 CDD:278556 8/49 (16%)
PH_MRCK 1049..1182 CDD:269949 37/133 (28%)
CNH 1211..1486 CDD:279162
CRIB 1544..1580 CDD:238077
ROCK2XP_005246247.1 STKc_ROCK2 39..417 CDD:270771 184/386 (48%)
S_TKc 92..354 CDD:214567 138/268 (51%)
SCP-1 412..1080 CDD:114219 140/725 (19%)
HR1_ROCK2 505..571 CDD:212028 8/65 (12%)
Rho_Binding 979..1046 CDD:286056 13/72 (18%)
PH_ROCK 1151..1257 CDD:269948 32/109 (29%)
C1 1261..1307 CDD:237996
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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