Protein Alignment gek and ROCK2

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: XP_005246247.1
• Gene: ROCK2 / 9475
• HGNCID: 10252
• Length: 1417
• Species: Homo sapiens
• Alignment Length: 1322
• Identity: 371/1322 - (28%)
• Similarity: 610/1322 - (46%)
• Gaps: 327/1322 - (24%)

  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            :::.|||....|..:....:||:.|.:.:||...:..|..:|.|::..:|:|::|:|||||||||
Human    42 NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV 106

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .:|:..:::||||||:|:|:||:||:::|.|.||||::.|.:..|:..|.|||||:..||:||:|
Human   107 QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEY 171

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            ..||||:.|:|.::  :||..||||..|::||:::||.:..:|||:||||:||||.||::|||||
Human   172 MPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG 234

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAES 309
            :|:::|:.|.|..:.|||||||||||:|:: :.|.|.||.||||||:||.:||||.|:|||||:|
Human   235 TCMKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS 298

  Fly   310 LVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID- 373
            ||.||.|||:|:|....|.    :.::|:.:::|:|..:...|.|||:||:::...||:|....
Human   299 LVGTYSKIMDHKNSLCFPE----DAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQW 359

  Fly   374 -WKNIRQGPAPYVPEVSSPTDTSNF-DVDDN--DVRLTDSIPPSANPAFSGFHLPFIGFTFSLTS 434
             |.|||:..||.|||:||..|:||| |::|:  ||. |..||    .||.|..|||||||:...:
Human   360 HWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVE-TFPIP----KAFVGNQLPFIGFTYYREN 419

  Fly   435 SSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQH 499
            ....||...:.:       |:|.|       ..|.|:.....:|..|.:.|:...|.|.||.::.
Human   420 LLLSDSPSCRET-------DSIQS-------RKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKC 470

  Fly   500 NEVFERLKTQDSELQDAIS------------QRNIAMMEY--SEVTEKLSELRNQKQKLSRQVRD 550
            ..|..||:....||::.|:            :|..|::::  :|...|.....::|:.|...|..
Human   471 KSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNS 535

  Fly   551 KEEELDGAMQKNDS---------------------LRNE------LRK----SDKTRRELE---- 580
            .:::|:...::|.:                     ||.|      |||    |.|..::||
Human   536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 600

  Fly   581 -LHIEDAVIEAAK----------------EKKLREHAED--------CC---------------- 604
             |..::.::|.||                |::.|.|..:        .|
Human   601 DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKV 665

  Fly   605 ----RQLQ-----MELRKGSSSVETTMPLSI----------------------------SSEMSS 632
                ||||     :|..|.:..::.|..|.:                            ..|..|
Human   666 ELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKS 730

  Fly   633 YEIERLELQFSEKLSHQQTRHNMELEA-------------LREQFSEL---------ENANLALT 675
            ..::.:|.:..|:.:.:|...|:.|||             .:::.:||         :..||.|.
Human   731 EAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLK 795

  Fly   676 KELQQTQER-LKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED 739
            .| |:||:| |....::..|....||...:||...|.:...|.|..|..:   .::..||.|..|
Human   796 IE-QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ---NAELRKERQDAD 856

  Fly   740 DEIFKELRMKREA----ITLWERQMAEI-----------------IQWVSDEKDA-RGYLQALAT 782
            .:: |||:.:.||    .||::.|:.|:                 .|.:.||:|: ...|:...|
Human   857 GQM-KELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLT 920

  Fly   783 KM-TEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDK-MELLNLQSALQREIQAKNMISDELSQTR 845
            |. :|:|.          ..:..:.:.:...:|:.| :|:..:.:..::|:..|:.....|.:|.
Human   921 KADSEQLA----------RSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETN 975

  Fly   846 SDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGG----LEYSESFLNKSTHHGLSSAFFRD 906
            ..|.|....:.:.|:..::.|.|.|::.:.|:|.:...    .::.:..|.:.|   |.:   :.
Human   976 RTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERT---LKT---QA 1034

  Fly   907 MSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREE 971
            ::|.:||::..|.             .:.||...:...|.    :|.|.|..:|.      .||:
Human  1035 VNKLAEIMNRKEP-------------VKRGNDTDVRRKEK----ENRKLHMELKS------EREK 1076

  Fly   972 -SDQLVK------ESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHT 1029
             :.|::|      |.|.::...:.|...|..|..|  |.:....|...|.           |.|
Human  1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDS--KDSDIEQLRSQLQ-----------ALH- 1127

  Fly  1030 ICCQKVPTTCPVPMDQTKRPLGIDPT---RGIGTA----------YEGYVKVP-KSGVIKRGWIR 1080
                                :|:|.:   .|.|.|          .||::.:| ::...|.||::
Human  1128 --------------------IGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVK 1172

  Fly  1081 QFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTA 1145
            ::|:|...|:..||...|:   ...:...|||: |..|.|..|.::||..|..|::|.||:|
Human  1173 KYVIVSSKKILFYDSEQDK---EQSNPYMVLDI-DKLFHVRPVTQTDVYRADAKEIPRIFQI--- 1230

  Fly  1146 LIDGGLSLNTLMLADNESEKSK 1167
                        |..||.|..|
Human  1231 ------------LYANEGESKK 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	171/336 (51%)
		KELK	477..556	CDD:464876	20/92 (22%)
		CCDC158	<481..>894	CDD:464943	114/590 (19%)
		C1_MRCK	990..1042	CDD:410359	8/51 (16%)
		PH_MRCK	1049..1182	CDD:269949	37/133 (28%)
		CNH	1215..1484	CDD:459938
		CRIB	1544..1580	CDD:238077
ROCK2	XP_005246247.1	STKc_ROCK2	39..417	CDD:270771	184/386 (48%)
		SMC_prok_B	<430..1126	CDD:274008	146/766 (19%)
		HR1_ROCK2	505..571	CDD:212028	8/65 (12%)
		ROCK_SBD	856..936	CDD:409019	19/90 (21%)
		PH_ROCK	1151..1257	CDD:269948	32/109 (29%)
		C1_ROCK2	1250..1320	CDD:410425