DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gek and BRSK2

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_016874022.1	Gene:	BRSK2 / 9024	HGNCID:	11405	Length:	880	Species:	Homo sapiens

Alignment Length:	724	Identity:	158/724 - (21%)
Similarity:	277/724 - (38%)	Gaps:	142/724 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 KIIGRGAFGEVCV-VQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFG--DRQWITNLHY 165
            |.:|:|..|.|.: |..::.:|| |:||:|:   .|.:|:...:.||::.:..  :...:..||.
Human    23 KTLGKGQTGLVKLGVHCVTCQKV-AIKIVNR---EKLSESVLMKVEREIAILKLIEHPHVLKLHD 83

  Fly   166 AFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNV 230
            .:::...||||:::..||:|...|.|.....|::..||: .::|.|::..|.....|||:||:|:
Human    84 VYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF-RQIISALDFCHSHSICHRDLKPENL 147

  Fly   231 LLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCM 295
            |||::.::|:||||.......|..:::  :.|:|.|..||::|    |:...|.:.|.||.||.:
Human   148 LLDEKNNIRIADFGMASLQVGDSLLET--SCGSPHYACPEVIR----GEKYDGRKADVWSCGVIL 206

  Fly   296 YEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGI 360
            :.:|.|..||..::|.:...|:  .:..|::|      :.:....|.||..:|.:...|  :..:
Human   207 FALLVGALPFDDDNLRQLLEKV--KRGVFHMP------HFIPPDCQSLLRGMIEVDAAR--RLTL 261

  Fly   361 QDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVD------------DNDVRLTDSIPPS 413
            :....|.|::|...:...:.|.|...::.|.....:.|.|            |.:..|.|.:...
Human   262 EHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEE 326

  Fly   414 ANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETP----VD 474
            .|.....:.|             .||.|:...|...:|            ||..|...|    ||
Human   327 ENQEKMIYFL-------------LLDRKERYPSQEDED------------LPPRNEIDPPRKRVD 366

  Fly   475 ---------------SVQLKALND-----------QLAALKQEKAELSKQHN--EVFERLKTQDS 511
                           |:::.::.|           ::|...|.||..||..:  |...:...:|
Human   367 SPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQSKAMFSKSLDIAEAHPQFSKED- 430

  Fly   512 ELQDAISQRNIAMMEYSEVTEKLSELRNQKQK-----------LSRQV-RDKEEELDGAMQKND- 563
                  ..|:|:.......|..||..|..::.           ::|.: ...|.|..|:..:..
Human   431 ------RSRSISGASSGLSTSPLSSPRPIRKLVLPPPPPEPPFVARPLATSTEPEACGSASRPGH 489

  Fly   564 --SLRNELRKSDKTRR-ELELHIEDAVIEAAKEKKL------REHAEDCCRQLQMELRKGSSSV- 618
              .|:..||...||:. ..:..:.|..::..|....      |..|...|.||...|...:..|
Human   490 VLPLQAALRPDPKTQTLPCKAKLTDKPLQGTKSNPFPASTPARPPATGLCPQLAPPLGPPALRVP 554

  Fly   619 ETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELEN-------------- 669
            ....|..|.....|....::....|.:.|...|.....:...:|..:...|
Human   555 PRPPPAGIEPNTKSVPTIQVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPW 619

  Fly   670 -ANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSE----VNLKS 729
             |.|...|.......|....:::..|....:.|..:...:|.|.|||.....|..|    |.:|.
Human   620 RARLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD 684

  Fly   730 KSLKELQAE 738
            |.|..::|:
Human   685 KPLSSIKAD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	87/340 (26%)
		S_TKc	100..369	CDD:214567	75/267 (28%)
		KELK	478..556	CDD:292424	18/102 (18%)
		CEP63	492..749	CDD:293650	56/291 (19%)
		CEP63	652..880	CDD:293650	20/106 (19%)
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
BRSK2	XP_016874022.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000