DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and DCLK3

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_001381601.1	Gene:	DCLK3 / 85443	HGNCID:	19005	Length:	817	Species:	Homo sapiens

Alignment Length:	406	Identity:	103/406 - (25%)
Similarity:	166/406 - (40%)	Gaps:	105/406 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LRREKG-VSDFLKLSKPFVHIVRKLRLSRDD---------------------------------- 99
            |||.:| ..:..|..||.:...|::.| |||
Human   456 LRRTRGEEKEAEKEKKPCMSGGRRMTL-RDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAA 519

  Fly   100 -----FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQW 159
                 ::..::||.|.|..|...:...|.:.|||||::| ..||..|...   :.::|:......
Human   520 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDK-SRLKGKEDMV---DSEILIIQSLSH 580

  Fly   160 --ITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVH 222
              |..||..::.::.:||:::|..||||...:.: ..|.||..|...|.::..|:..:|....||
Human   581 PNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIE-SVKFPEPDAALMIMDLCKALVHMHDKSIVH 644

  Fly   223 RDIKPDNVLL----DKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYG 283
            ||:||:|:|:    ||...::|||||    |.|..........|||.|::||||    ..|| ||
Human   645 RDLKPENLLVQRNEDKSTTLKLADFG----LAKHVVRPIFTVCGTPTYVAPEIL----SEKG-YG 700

  Fly   284 TECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNY------KVSETSQD 342
            .|.|.|:.||.:|.:|.|..||.:..        .:....||:.......:      .:|:.::|
Human   701 LEVDMWAAGVILYILLCGFPPFRSPE--------RDQDELFNIIQLGHFEFLPPYWDNISDAAKD 757

  Fly   343 LLCKLICI-PENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRL 406
            |:.:|:.: |:.|...:.:   :.|||.                 |.:..|:|         |:.
Human   758 LVSRLLVVDPKKRYTAHQV---LQHPWI-----------------ETAGKTNT---------VKR 793

  Fly   407 TDSIPPSANPAFSGFH 422
            ...:.||:...|...|
Human   794 QKQVSPSSEGHFRSQH 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	93/377 (25%)
		S_TKc	100..369	CDD:214567	82/281 (29%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
DCLK3	NP_001381601.1	STKc_DCKL3	524..781	CDD:271087	81/281 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000