DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and CDC42BPA

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_001374479.1	Gene:	CDC42BPA / 8476	HGNCID:	1737	Length:	1845	Species:	Homo sapiens

Alignment Length:	1671	Identity:	744/1671 - (44%)
Similarity:	1047/1671 - (62%)	Gaps:	185/1671 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGR 108
            |.|..||::.|||..|.|||||:||.|||||.:.::|:.:|||...|:::||.|:||:|||:|||
Human    21 TNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGR 85

  Fly   109 GAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINL 173
            ||||||.||::.:.:||:|||||||||||||||||||||||||||.||.:|||.|||||||:.||
Human    86 GAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNL 150

  Fly   174 YLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHV 238
            |||||||.|||||||||||||:||||||:||:.||::||:|:||:.||||||||||:|:|..||:
Human   151 YLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHI 215

  Fly   239 RLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGET 303
            |||||||||:|.:||||||:||||||||||||||:||||||||||.|||||||||||||||||||
Human   216 RLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGET 280

  Fly   304 PFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPW 368
            |||||||||||||||||:..|..|:|.|   .|||.::||:.:|||..|:|||||||:||..||:
Human   281 PFYAESLVETYGKIMNHKERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPF 342

  Fly   369 FVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLT 433
            |.||||.|||...|||:||||||||||||||||:.::.::::||..:.||||.||||:|||:  |
Human   343 FSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTY--T 405

  Fly   434 SSSTLDSKKNQSSGFGDDTLD-------------------------------------------- 454
            ||..|..:.......|..:||
Human   406 SSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQ 470

  Fly   455 -----TISSPQLA-------------------ILPSNNSETPVDSV------------QLKALND 483
                 |:..|..|                   :..|::.|..::..            |:||...
Human   471 ALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEK 535

  Fly   484 QLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQV 548
            |:..|:||:.:|:|:..:..||||.|..||:||..||.:||.|:.|:.|:|:||..|||||:|.|
Human   536 QIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600

  Fly   549 RDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELR- 612
            ||||||:|..|||.:|||.|||::::.::|||:|.|....||:|::||||.:|...:||:.||.
Human   601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEG 665

  Fly   613 ---------KGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELE 668
                     .|..|:|....::    ....::|:..:.:.|:||.::..|..|::.|:::..:.|
Human   666 LKQKQISYSPGVCSIEHQQEIT----KLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSE 726

  Fly   669 NANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVN-----LK 728
            ...|||.||:...:::|:.|:.||.::..|...|.|:|::.||....||.::|:||::     .:
Human   727 GQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYE 791

  Fly   729 SKSLKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKH 793
            :.|:...|.|::  .|:|..|:|::..||.|:.||||||||||||||||||||:|||||||.|::
Human   792 NLSIHNQQLEEE--VKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRN 854

  Fly   794 --VGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVR 856
              :||    ...:..|:.||..|||....|.|||||..||:||..|.:||::.::..|.|:.:::
Human   855 SSLGT----RATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLK 915

  Fly   857 DYKKRYDSILHDFQK--KETELRDLQKGGLEYSES------FLNKSTHHGLSSAFFRD--MSKNS 911
            |.:|:...:|.:.::  |:||....:| |:|:.:|      |||..| ..|..  |.|  .|.:|
Human   916 DSEKKNLELLSEIEQLIKDTEELRSEK-GIEHQDSQHSFLAFLNTPT-DALDQ--FEDSFSSSSS 976

  Fly   912 EIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYA-GKNNKDHSSMKEASVSDLSREESDQL 975
            .:||..        |:.:|:...:.........|..|. ..:.|.|...:..|.|..|..|..:.
Human   977 SLIDFL--------DDRSPSCTPASKGRRTDPVENTYVWNPSVKFHIQSRSTSPSTSSEAEPVKT 1033

  Fly   976 VKES----------QKKVPGNTAI------HQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICG 1024
            |..:          :|..||:|..      |||.|::|::||||:.||||||||.|||..||:||
Human  1034 VDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCG 1098

  Fly  1025 FACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFK 1089
            |:||..|..|.|||||||.:|||.||||||.:||||||||:|::||...:|:||.|...:|||||
Human  1099 FSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFK 1163

  Fly  1090 LFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLS-L 1153
            ||||||:..:.:.|||.:|||:||||.||||.||..||||||::||:||||::..:.:....: .
Human  1164 LFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKC 1228

  Fly  1154 NTLMLADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQIL 1218
            :.|||||.|:||:|||..|.|||:|||:|...:.:::...|..|:||.||:....:.||...:|.
Human  1229 SILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIA 1293

  Fly  1219 LGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIK 1283
            ||.|:|||.:::.:.||.|:|::|||.|:..|..:|::.::.|:.|::||.|:.||:..:.::.|
Human  1294 LGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYK 1358

  Fly  1284 VVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHL 1348
            :.|:|.|.:..:|.:|.  ..:....:|:||     |::.||:.:::|||:|..|..:.|..|.:
Human  1359 LSETKGCQTVTSGKVRH--GALTCLCVAMKR-----QVLCYELFQSKTRHRKFKEIQVPYNVQWM 1416

  Fly  1349 QILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEY 1413
            .|.|: :|.|..||||..|.|.||....|::|..:...:|:.:..:||:..:||      :..||
Human  1417 AIFSE-QLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEI------SSKEY 1474

  Fly  1414 LLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQ 1478
            ||.|.::.||.|.|||:||.:|:|:||.|:...:...:|.|:|:..:|||:..:.||:|::.||:
Human  1475 LLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKK 1539

  Fly  1479 SLPLNNLGNVVLSSVNDTPLIVYLSNIHTKG----LLQYRDGNRKGLP---SIKRRFSIREINKT 1536
            ..||||.|::.|..: :|..::|..|...:|    :.:..|.:||.:.   :.|||:|.|...:.
Human  1540 VRPLNNEGSLNLLGL-ETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEE 1603

  Fly  1537 IKSDR---------RSKMISAPTNFNHISHMGPGDGIQNQRLLDLP 1573
            ....|         |:|:||.|||||||:||||||||  |.|.|||
Human  1604 RMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGI--QILKDLP 1647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	247/331 (75%)
		S_TKc	100..369	CDD:214567	207/268 (77%)
		KELK	478..556	CDD:292424	40/77 (52%)
		CEP63	492..749	CDD:293650	97/271 (36%)
		CEP63	652..880	CDD:293650	91/236 (39%)
		C1_1	990..1040	CDD:278556	32/49 (65%)
		PH_MRCK	1049..1182	CDD:269949	78/133 (59%)
		CNH	1211..1486	CDD:279162	97/274 (35%)
		CRIB	1544..1580	CDD:238077	23/30 (77%)
CDC42BPA	NP_001374479.1	STKc_MRCK_alpha	4..412	CDD:270773	280/395 (71%)
		SbcC	432..>941	CDD:223496	171/518 (33%)
		KELK	530..608	CDD:406277	40/77 (52%)
		C1_MRCKalpha	1062..1121	CDD:410414	37/58 (64%)
		PH_MRCK	1123..1257	CDD:269949	78/133 (59%)
		CNH	1283..1547	CDD:395630	97/277 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143115
Domainoid	1	1.000	441	1.000	Domainoid score	I549
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55765
Inparanoid	1	1.050	1170	1.000	Inparanoid score	I202
Isobase	1	0.950	-	0	Normalized mean entropy	S1690
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm42112
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790