DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gek and Rock1

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:NP_001376168.1 Gene:Rock1 / 81762 RGDID:620424 Length:1354 Species:Rattus norvegicus


Alignment Length:1270 Identity:353/1270 - (27%)
Similarity:590/1270 - (46%) Gaps:278/1270 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 DYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCV 116
            |.|||....|..:....:||:.|.:.:||...|..::.:|.||:..:|::::|:|||||||||.:
  Rat    28 DCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQL 92

  Fly   117 VQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYC 181
            |:..||.||||||:|:|:||:||:::|.|.||||::.|.:..|:..|.|||||:..||:||:|..
  Rat    93 VRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMP 157

  Fly   182 GGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSC 246
            ||||:.|:|.::  :||..|:||..|::||:::||.:.::|||:||||:||||.||::|||||:|
  Rat   158 GGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC 220

  Fly   247 LRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLV 311
            ::::|:|.|:.:.|||||||||||:|:: :.|.|.||.||||||:||.:||||.|:|||||:|||
  Rat   221 MKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLV 284

  Fly   312 ETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID--W 374
            .||.|||||:|....|...    .:|:.:::|:|..:...|.|||:||:::...|.:|....  |
  Rat   285 GTYSKIMNHKNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAW 345

  Fly   375 KNIRQGPAPYVPEVSSPTDTSNFD--VDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF-----SL 432
            :.:|...||.||::||..||||||  .:|.....|..||    .||.|..|||:|||:     .|
  Rat   346 ETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIP----KAFVGNQLPFVGFTYYSNRRYL 406

  Fly   433 TSSSTLDSKKNQSSGFGDDTLDTISSPQLAIL------------------PSNNSETPVDSV--- 476
            .|:   :..:|:||...|..:.  .|.|..|.                  ....|...:|.:   
  Rat   407 PSA---NPSENRSSSNVDKNVQ--ESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKE 466

  Fly   477 ------QLKALNDQLAALKQEKAELS----------KQHNEVFERLKTQDSELQDAISQRNIAMM 525
                  |.:.|...::.:::||..|.          :|.||....::.:.|.|:|.:.....|..
  Rat   467 LDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLRKASQ 531

  Fly   526 EYSEVTEKLSELRNQKQKLSRQVRDKEE----------ELDGAMQKNDSL------RNELRKSDK 574
            ......|||::|:.|.::.:..:|.:.:          |:..::.:.:||      ||.:.::.|
  Rat   532 SSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSVSQLESLNRELQERNRMLENSK 596

  Fly   575 TRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMEL---------------------------- 611
            ::.:.:.:...||:||  |::.|.|..:....||..:                            
  Rat   597 SQADKDYYQLQAVLEA--ERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDML 659

  Fly   612 ---RKGSSSVETTMPLSISS-------EMSSYEIERLEL----------------QFSEKLSHQ- 649
               .|..:::|..:...:.|       |::.:::.:..|                :..:||..: 
  Rat   660 NHSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEER 724

  Fly   650 QTRHNME-----------------------LEALREQFSELENANLALTKELQQTQERLKYTQME 691
            :.|...|                       ||.|.|....||:|..:||.:|:|...:....|.|
  Rat   725 EAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERLEDAVKSLTLQLEQESNKRILLQSE 789

  Fly   692 SITDS--AETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAEDDEIFKELRMKREAIT 754
            ..|.:  |:.|..|:||...|.::..|.|:.|..|:...:|..:..:.:..|:..:|..::...|
  Rat   790 LKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFST 854

  Fly   755 LWERQMAEI--------------IQWVSDEKD------------------ARGYLQALATKMTEE 787
            |::.|:.|:              ||.:..||:                  |||.|:....::|:|
  Rat   855 LYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQYFELTQE 919

  Fly   788 LEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQ 852
                                 ::::...::.|:.:....:.|..:|.|.::.::...|.:.....
  Rat   920 ---------------------SKKAASRNRQEITDKDHTVSRLEEANNALTKDIELLRKENEELN 963

  Fly   853 KEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSA 917
            :.:|..::.|.      .|||.|:.:| |...|     .|.||...|.:   :.::|.:||::..
  Rat   964 ERMRTAEEEYK------LKKEEEISNL-KAAFE-----KNISTERTLKT---QAVNKLAEIMNRK 1013

  Fly   918 ESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNN---KDHSSMKEASVSDLSREESDQLVKES 979
            :                       |..:.|.|...:   |:..:.|.....:..||:.:|:|.:.
  Rat  1014 D-----------------------FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKH 1055

  Fly   980 QKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVP-M 1043
            ||::  |....|.:       .:|.|...|.:.|..:  ..:|.......:......:....| .
  Rat  1056 QKEL--NDMQAQLV-------EECTHRNELQMQLASK--ESDIEQLRAKLLDLSDSTSVASFPSA 1109

  Fly  1044 DQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKR-GWIRQFVVVCDFKLFLYDISPDRCALPSVSV 1107
            |:|...|   |...|    ||::.||..|.||| ||.:|:|||...|:..|:...|:   ...|.
  Rat  1110 DETDGNL---PESRI----EGWLSVPNRGNIKRYGWKKQYVVVSSKKMLFYNDEQDK---EQSSP 1164

  Fly  1108 SQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKI 1142
            |.|||: |..|.|..|.:.||..|..:::|.||:|
  Rat  1165 SMVLDI-DKLFHVRPVTQGDVYRAETEEIPKIFQI 1198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 166/335 (50%)
S_TKc 100..369 CDD:214567 138/268 (51%)
KELK 478..556 CDD:292424 18/97 (19%)
CEP63 492..749 CDD:293650 66/362 (18%)
CEP63 652..880 CDD:293650 54/284 (19%)
C1_1 990..1040 CDD:278556 6/49 (12%)
PH_MRCK 1049..1182 CDD:269949 36/95 (38%)
CNH 1211..1486 CDD:279162
CRIB 1544..1580 CDD:238077
Rock1NP_001376168.1 STKc_ROCK1 2..406 CDD:270772 181/388 (47%)
Interaction with FHOD1. /evidence=ECO:0000250 368..727 66/369 (18%)
SMC_prok_B 426..>1097 CDD:274008 127/742 (17%)
HR1_ROCK1 489..554 CDD:212029 13/64 (20%)
SHROOM3 binding. /evidence=ECO:0000250|UniProtKB:Q13464 707..946 48/259 (19%)
ROCK_SBD 836..913 CDD:409019 14/76 (18%)
RHOA binding. /evidence=ECO:0000250 998..1010 3/14 (21%)
PH_ROCK 1119..1225 CDD:269948 34/88 (39%)
C1_ROCK1 1222..1290 CDD:410424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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