DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and cdc42bpb

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_021324167.1	Gene:	cdc42bpb / 567039	ZFINID:	ZDB-GENE-030131-3647	Length:	1789	Species:	Danio rerio

Alignment Length:	1785	Identity:	761/1785 - (42%)
Similarity:	1060/1785 - (59%)	Gaps:	251/1785 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQ-----FSLDYLLDTFIVLYDECSNSSLRREK 74
            |.|.||..|:.:|.|                |||     .|::.|||..|.||:|||||.|:|||
Zfish     2 SAKVRLKKLEQLLLD----------------GHQKNDKSLSVETLLDILICLYNECSNSPLKREK 50

  Fly    75 GVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKR 139
            .|:|||:..|||...|:::||.||||::||:|||||||||.||:|..||:|||||||||||||||
Zfish    51 HVTDFLEWVKPFTTTVKEMRLHRDDFEMLKVIGRGAFGEVAVVKMKHTERVYAMKILNKWEMLKR 115

  Fly   140 AETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFY 204
            ||||||||||:|||.||.||||.|||||||:..||||||||.|||||||||||||:|||||||||
Zfish   116 AETACFREERNVLVNGDCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFY 180

  Fly   205 ITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISP 269
            :.||:|||:||||.|||||||||||||||..||:|||||||||::.:||||||:|||||||||||
Zfish   181 VAEMVLAIHSIHQQRYVHRDIKPDNVLLDMNGHIRLADFGSCLKMMQDGTVQSSVAVGTPDYISP 245

  Fly   270 EILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNY 334
            |||:|||||.|:||.||||||||||||||||||||||||||||||||||||:..|..||..|
Zfish   246 EILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHIT--- 307

  Fly   335 KVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDV 399
            .|||.::||:.:|||..|.||||:||::|..|.:|.||||:|||...|||:|:||||:|||||||
Zfish   308 DVSEDAKDLIQRLICSRERRLGQHGIEEFRKHAFFSGIDWENIRNMEAPYIPDVSSPSDTSNFDV 372

  Fly   400 DDNDVRLTDSIPPSANPAFSGFHLPFIGFTF---------------SLTSSST------------ 437
            ||:.::..|..||.::..|:|.||||:|||:               :|:...|
Zfish   373 DDDVLKNPDIAPPVSHTGFTGQHLPFVGFTYTTESCFSDGGSMRGVALSDGGTGEDLQDGGMQVE 437

  Fly   438 ---------------LDSKKNQS---------SGFGDDTL----------DTISSPQLAILPSNN 468
                           |:.|..:|         ||.|..||          :.|...:..:..|:.
Zfish   438 AFEKRIRCLEQEKLELNRKLQESTQAVQSLHGSGRGAGTLGRDKEIKKLNEEIDRLKKKLADSDR 502

  Fly   469 SETPVD------------SVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRN 521
            .|..::            |.:||||:.|:.|||.||.::.||..|..:|||:|..||:||..||.
Zfish   503 LEHQLEEAVTLRQDFESSSTKLKALDKQVKALKLEKEDIHKQLVESLDRLKSQTKELKDAHQQRK 567

  Fly   522 IAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDA 586
            :||.|:|||.|:::|||:|||:||||:||||||::..|||.|::|.::||::|.|:|||..:|||
Zfish   568 LAMQEFSEVNERMAELRSQKQRLSRQLRDKEEEMEVVMQKIDAMRQDIRKTEKARKELESQLEDA 632

  Fly   587 VIEAAKEKKLREHAEDCCRQLQMEL----------RKGSSSVETTMPLSISSEMSSYEIERLELQ 641
            ..||:||:|||||:|...:||:.||          |......||...|   :::.| |:::..|.
Zfish   633 RAEASKERKLREHSEVYSKQLESELETLKVKQGAGRASGLGAETQQEL---TKLKS-ELDKKGLY 693

  Fly   642 FSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQ 706
            :.|:|..::..|..|::.||::..:.|...|:|.|||...:|:|:..:.|...:..|.:..||:|
Zfish   694 YEEELVRREASHTTEMKNLRKELQDSEGQQLSLHKELLALKEKLEKAKRERQIEMEEAINALKEQ 758

  Fly   707 HDLEKSSWFEEKQRLSSEVNLKSKSLKELQAE----DDEIFKELRMKREAITLWERQMAEIIQWV 767
            ::.|::...|:.::|::|.:.....:.:|.|:    :||: :||..|:|::..||.|:|||||||
Zfish   759 YERERNLMSEDNRKLTAETDRLCSFVDKLTAQNRQLEDEL-QELASKKESVAHWEAQIAEIIQWV 822

  Fly   768 SDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQ 832
            ||||||||||||||:|||||||.|:. .:..:..:| ..|:.|||||||....|.|||||:.||:
Zfish   823 SDEKDARGYLQALASKMTEELESLRS-SSLGSRTLD-PLWKVRRSQKLDMSARLELQSALEAEIR 885

  Fly   833 AKNMISDELSQTRSDLISTQKEVRDYK---KRYDSILHDFQKKETELRDLQKGGL---EYSES-- 889
            ||.::.|||.:.::..||.:.:::|.:   :..:..|.:.:|:..|.|.....||   ::.:|
Zfish   886 AKQLVHDELRKVKAANISFESKLKDTEAKNRELEEQLENMKKEMEESRSRSDKGLKLPDFQDSIF 950

  Fly   890 -FLNKS-THHGLSSAFFRDMSKNSEIIDSAESFGNES---GDNFTPNFFQSGNSGMLFNYEPKYA 949
             :.|.| ..|.|:   ||| |.:|....|..:|.:|:   ||               .:..|:
Zfish   951 DYFNTSPLAHELT---FRD-SVSSSSASSLLAFWDETSSVGD---------------VDVAPQ-- 994

  Fly   950 GKNNKDHSSMKEASVSDLSREESDQLVK--------ESQKKVPGNTA----IHQFLVRTFSSPTK 1002
             |.:...||...|:       |.|:.||        .|....|..||    .||..::||||||:
Zfish   995 -KTDIPPSSPSAAT-------EQDEAVKPQATTPATPSPMYQPTLTAPKPKAHQLSIKTFSSPTQ 1051

  Fly  1003 CNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVK 1067
            |.||||||||..|||..||:|.|.||..|....|..||:|.:|||||||||..|||||||:|:|:
Zfish  1052 CTHCTSLMVGQMRQGYACEVCSFICHVSCKDNAPQLCPIPPEQTKRPLGIDVQRGIGTAYKGFVR 1116

  Fly  1068 VPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAA 1132
            :||...:|:||.|.:.||||.|||||::...:...|.|..|||||:||.||||.||..||||||.
Zfish  1117 IPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKSTQPVVMASQVLDLRDEEFSVSSVLASDVIHAN 1181

  Fly  1133 KKDVPCIFKIKTALIDGGL-SLNTLMLADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEIL 1196
            .|||||||::.::.:...: .:..|:||::|:||.|||..|..|..||.:|.|.|..:..::|..
Zfish  1182 HKDVPCIFRVTSSALKSSIRPVPLLILAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAY 1246

  Fly  1197 DNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCG 1261
            |::|..|:..|.:.|:...:|:||||||||.:.:.:..|.|..:.||:.|:..|.:|:::.:|.|
Zfish  1247 DSSLPAIKTTLSAAIVDRERIVLGTEDGLFVVEITRDVIVRAADCKKVCQIELIPKEKMVALLSG 1311

  Fly  1262 KQRNLRLLPIRALEASDVEW-IKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYE 1325
            :.|::.|.|..|||.::..: .|:.:::.|.:...|.:|  |.........:||     |:..||
Zfish  1312 RNRHVHLYPWAALEGAEGGFDAKLTDTRGCQAMTIGNLR--PGGPACLFAGVKR-----QVFCYE 1369

  Fly  1326 INRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLN 1390
            |.|.:..|:|..|.....:.|.|.|:.: |:.|.:.|||....::||::.:|||.|.:...|||.
Zfish  1370 ITRAKPHHRKLWEVQAPGVVQWLGIIRE-RICVGYPSGFALLAMQGESSPVSLVSPGDPSLAFLA 1433

  Fly  1391 YSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVF 1455
            ...:||:..:|:    |.|  |.||.|..|.:|||..||:||.:|:|:|:.|...:.....|.|:
Zfish  1434 QQPLDALHAMEV----GSN--ELLLCFSQLGVYVDATGRRSRTQELMWPSTPLACSSNSNCLTVY 1492

  Fly  1456 SDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSN--------------IH 1506
            ||..:|:|:..|.||||:|.|::..|||..|::.|.|: :.|.::|.||              .:
Zfish  1493 SDYGVDVFDVHTMEWVQTISLRKIRPLNVEGSLNLLSI-EQPHLIYFSNNSSDGCDLAIPETSDN 1556

  Fly  1507 TKGLLQYRDGNRKGLPSIKRRFSIREINKTIKS-DRRSKMISAPTNFNHISHMGPGDGIQNQRLL 1570
            :|.|:......||.|..:.....:::..:.::. :.|||:||.||||||::|||||||:  |.|:
Zfish  1557 SKKLMVRTRSKRKFLFKVPEEERLQQRREMLRDPEMRSKLISHPTNFNHVAHMGPGDGM--QVLM 1619

  Fly  1571 DLPTTLETADQACS--------PI----IHSLSCI---------PQSRKSNFLEQVDANS----- 1609
            |||...||...:.|        |.    ::.:|.:         |.|::|  |.|..::|
Zfish  1620 DLPLPSETPSPSSSRHHALISPPTNFEHVYHMSPVSAGLYLQKEPSSQQS--LLQFSSSSSSPST 1682

  Fly  1610 ------------DDYGNDNIISRTPSPMAS 1627
                        ||...|.     |.|::|
Zfish  1683 SSLGRSVMPSSQDDLSKDK-----PRPLSS 1707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	246/331 (74%)
		S_TKc	100..369	CDD:214567	208/268 (78%)
		KELK	478..556	CDD:292424	46/77 (60%)
		CEP63	492..749	CDD:293650	102/270 (38%)
		CEP63	652..880	CDD:293650	90/234 (38%)
		C1_1	990..1040	CDD:278556	28/49 (57%)
		PH_MRCK	1049..1182	CDD:269949	70/133 (53%)
		CNH	1211..1486	CDD:279162	94/275 (34%)
		CRIB	1544..1580	CDD:238077	23/35 (66%)
cdc42bpb	XP_021324167.1	PKc_like	3..411	CDD:328722	283/426 (66%)
		SbcC	<437..>935	CDD:223496	186/504 (37%)
		KELK	524..602	CDD:318090	46/77 (60%)
		C1	1039..1088	CDD:237996	28/48 (58%)
		PH_MRCK	1098..1232	CDD:269949	70/133 (53%)
		CNH	1258..1523	CDD:307087	94/278 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575965
Domainoid	1	1.000	441	1.000	Domainoid score	I522
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1217	1.000	Inparanoid score	I181
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm24491
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840