DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and cdc42bpab

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_021324156.1	Gene:	cdc42bpab / 566003	ZFINID:	ZDB-GENE-080219-17	Length:	1800	Species:	Danio rerio

Alignment Length:	1714	Identity:	740/1714 - (43%)
Similarity:	1050/1714 - (61%)	Gaps:	217/1714 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |.:.||..|:.::.|..|          .:.|..||::.|||..:.||||||:|.:||||.|.:|
Zfish     2 SVEVRLKKLEKLIMDGPS----------QSSGQCFSMETLLDILVCLYDECSSSPIRREKNVLEF 56

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            |..:|||...|:::||.::||:|||:|||||||||.||::.:|:||:||||||||||||||||||
Zfish    57 LDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETAC 121

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||.||.||||.|||||||..|||||||||.|||||||||||||:|||||||||:.||:
Zfish   122 FREERDVLVNGDCQWITTLHYAFQDENNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMV 186

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:|:||:.||||||||||:|:|..||:|||||||||:|.:||||||:||||||||||||||:|
Zfish   187 LAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQA 251

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNC-------FNLPSQETL 332
            ||||||:||.||||||||||||||||||||||||||||||||||||::.       |..|.|.|
Zfish   252 MEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKSSQPNDEERFQFPLQVT- 315

  Fly   333 NYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNF 397
              .|||.::||:.:|||..|:|||||||:||..||:|.||||.|||...|||:||||||||||||
Zfish   316 --DVSEDAKDLVRRLICSREHRLGQNGIEDFKQHPFFTGIDWDNIRTCEAPYIPEVSSPTDTSNF 378

  Fly   398 DVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDT------- 455
            ||||:.::..:::||.::.||||.||||:|||:  ||..||..:.......|...:|.
Zfish   379 DVDDDCLKNCETLPPPSHTAFSGHHLPFVGFTY--TSKCTLSDRGCLRESVGPAQVDAHVQRSLE 441

  Fly   456 ---------------------------ISSPQLAILPSNNSETPVDS---VQLKALNDQLAALK- 489
                                       .|:..:..|...:|:.||::   |::::|..::..||
Zfish   442 ESLASEAYERRIRRLEQEKTELTRKLQESTQTVQALQYPDSDAPVNANKEVEIRSLKSEIDILKK 506

  Fly   490 ----------------------------------------QEKAELSKQHNEVFERLKTQDSELQ 514
                                                    |||.:|.|:...:.|::|.|..||:
Zfish   507 QIADSGQMEQQLENASTARRDLEDSSKVVRNLEKQLKSVTQEKDDLHKELLGLAEKVKAQGKELK 571

  Fly   515 DAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRREL 579
            ||.||:.:|:.|::|:.|:||::|.|||:||||.:|||||::|..||.::||.|:||:::.|:||
Zfish   572 DAHSQKKMAIKEFAELNEQLSDVRTQKQRLSRQFKDKEEEMEGVSQKLEALRLEIRKAERMRKEL 636

  Fly   580 ELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPL--SISSEMSS------YEIE 636
            |...|:...||.||:|:||..|...:||:.|| :|...::.|.|.  :.||:...      .|:|
Zfish   637 EAQAEEHAAEAQKERKVRERTEQYSKQLEEEL-EGMKQLKQTGPPNGAASSDQQQELMRVRAELE 700

  Fly   637 RLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLL 701
            :..:|:.|::..::|.|:.|::.|:::..:.|..:|...||:...:::|:.|:.||..:..|.:.
Zfish   701 KKSVQYEEEMCRRETLHSSEMKNLQKELRDAEGQHLTHQKEILVLKDKLEKTRRESQVEREEFVC 765

  Fly   702 ELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED---DEIFKELRMKREAITLWERQMAEI 763
            |.|::::.||:...:|.::||:||...:...::|.:..   :|..:||..|:|::..||.|:.||
Zfish   766 EYKQKYEREKAHLTDENKKLSAEVEKLNGQFEQLSSSHRQLEEEMRELADKKESVAHWEAQITEI 830

  Fly   764 IQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQ 828
            ||||||||||||||||||||||||||.|::. :....|.| ..|:.||..|||....|.|||||.
Zfish   831 IQWVSDEKDARGYLQALATKMTEELEGLRNT-SLGARGTD-MPWKMRRFAKLDMSARLELQSALD 893

  Fly   829 REIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQ--KKETELRDLQKGGLEYSES-- 889
            .||:||..|.|||::.::..|:|:.::::.:.|...:|.:.:  :||||...|:: |:::.:|
Zfish   894 TEIRAKQSIQDELNKVKATNIATECKLQESESRNQELLGEIERLRKETEELRLRR-GVKHQDSQN 957

  Fly   890 ----FLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGN-------ESGDNFTPNFFQSGNSGMLFN 943
                |||..|     ||.        :..|.:.|||.       :|.| |||:...|.:..
Zfish   958 SFLAFLNAPT-----SAL--------DQFDRSPSFGPGSKTRRLDSAD-FTPSNTPSRDED---- 1004

  Fly   944 YEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTA---------------IHQFL 993
                  .::.:...|...::.||:   |..:|:..:.:.:...|.               .|||.
Zfish  1005 ------ARSRRISRSRSPSTASDM---EPIELIDHTSRSLQTPTGRSGYGSLGHSSPKPKAHQFS 1060

  Fly   994 VRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGI 1058
            |::|:.|||||.||||||||.|||..||.|.|:||..|..|.|:.|||..|||:..||||..|||
Zfish  1061 VKSFNVPTKCNQCTSLMVGLIRQGCTCEACSFSCHVTCADKAPSVCPVAPDQTRGKLGIDTQRGI 1125

  Fly  1059 GTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSV 1123
            ||||||:::|||...:|:||.|.:.||||||||||::...:.|.|.|.|:||:||||.|||..||
Zfish  1126 GTAYEGHLRVPKPTGVKKGWQRVWAVVCDFKLFLYELGEGKGAQPGVVVNQVIDMRDEEFSASSV 1190

  Fly  1124 RESDVIHAAKKDVPCIFKIKTALIDGGLSLNT--LMLADNESEKSKWVIALGELHRILKRNSLPN 1186
            .|||||||.:||:||||::..:.:....|..|  |:|||||.|::|||.||.||||||::|.|..
Zfish  1191 LESDVIHANRKDIPCIFRVTASQLSASSSQKTCILILADNEQERTKWVCALNELHRILRKNKLKE 1255

  Fly  1187 TAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIE 1251
            ..::...|..|:||.||:....:.||...::.||.|:|||.|::.:.||.|:|:.||:..:..:.
Zfish  1256 RFVYVPKEAYDSTLPLIKTTQTAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDVKKVHHVELMP 1320

  Fly  1252 EEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPN 1316
            .|.||.::.|:.|.:.|:.:..|:..:|:..||.::|||....:|::|.    |..|.:|:||
Zfish  1321 TEHILAVISGRNRQVCLVSMAGLDGREVDKNKVADTKNCQLLVSGVVRN----VTCFCLAIKR-- 1379

  Fly  1317 NHTQIVVYEINRTRTRHQKTCEF----TIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMS 1377
               ||..:|||::::||....:.    |:.:||     |.:.:|.|.:.|||..|.|.||....|
Zfish  1380 ---QISCFEINKSKSRHSHLVDIQAPGTVQWMA-----LFNQQLCVGYPSGFMRYSLYGETPPAS 1436

  Fly  1378 LVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFP 1442
            |:||::...||:....:||:..:||      :..|.||.|..:|:|||..||:||.:|:|:||.|
Zfish  1437 LLHPDDPTLAFIKTDNLDALCAVEI------SNKELLLCFSKIAVYVDTHGRRSRQQELMWPAAP 1495

  Fly  1443 TYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHT 1507
            |...:...:|.|:|:..:|:|:..:.||:|:|.||:..|||..|::.|..: :|..::|..|...
Zfish  1496 TACCYNAPYLSVYSENAVDVFDVNSTEWIQTIPLKKVRPLNMDGSLNLLGL-ETVRLIYFRNKTA 1559

  Fly  1508 KG----LLQYRDGNRKGL---PSIKRRFSIR--------EINKTIKS-DRRSKMISAPTNFNHIS 1556
            :|    :.:..|.:||.:   .|.|||||.|        :..:.:|. :||:|:||.||||||::
Zfish  1560 EGDELVVPEVCDNSRKQMVRSMSNKRRFSFRIPEEERLQQRREMLKDPERRNKLISNPTNFNHVA 1624

  Fly  1557 HMGPGDGIQNQRLLDLPTTLETAD 1580
            |||||||:|..|  |||..:...|
Zfish  1625 HMGPGDGMQILR--DLPMNVRAQD 1646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	250/338 (74%)
		S_TKc	100..369	CDD:214567	210/275 (76%)
		KELK	478..556	CDD:292424	36/118 (31%)
		CEP63	492..749	CDD:293650	91/267 (34%)
		CEP63	652..880	CDD:293650	89/232 (38%)
		C1_1	990..1040	CDD:278556	30/49 (61%)
		PH_MRCK	1049..1182	CDD:269949	78/134 (58%)
		CNH	1211..1486	CDD:279162	97/278 (35%)
		CRIB	1544..1580	CDD:238077	21/35 (60%)
cdc42bpab	XP_021324156.1	STKc_MRCK_alpha	4..419	CDD:270773	286/429 (67%)
		SbcC	438..>945	CDD:223496	166/509 (33%)
		KELK	535..613	CDD:318090	33/77 (43%)
		DMPK_coil	887..947	CDD:117396	21/59 (36%)
		C1_1	1057..1107	CDD:278556	30/49 (61%)
		PH_MRCK	1117..1251	CDD:269949	78/133 (59%)
		CNH	1277..1539	CDD:307087	97/281 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575966
Domainoid	1	1.000	441	1.000	Domainoid score	I522
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55765
Inparanoid	1	1.050	1217	1.000	Inparanoid score	I181
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm24491
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940