DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and CDC42BPG

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_011543457.1	Gene:	CDC42BPG / 55561	HGNCID:	29829	Length:	1569	Species:	Homo sapiens

Alignment Length:	1588	Identity:	615/1588 - (38%)
Similarity:	879/1588 - (55%)	Gaps:	212/1588 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVC 115
            ||.|||..:.|:.|.|:..||||:.|:.||..:.|||..|::|||.||||:|||:|||||||||.
Human    22 LDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVT 86

  Fly   116 VVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYY 180
            ||:...|.:::|||:|:|||||||||||||||||||||.||.:|:|.|||||||...||||||||
Human    87 VVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYY 151

  Fly   181 CGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGS 245
            .|||||||||:|||:||.::|:||:.||:|||:|:||:.|||||:||||||||..||:|||||||
Human   152 AGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGS 216

  Fly   246 CLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESL 310
            ||||:.:|.|.|:||||||||||||||:|||:|||.||.:|||||||||.||:|:||||||||||
Human   217 CLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESL 281

  Fly   311 VETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWK 375
            ||||||||||::....|....   .|..::|||:.:|:|..|.|||:.|:.||.:||:|.|:||:
Human   282 VETYGKIMNHEDHLQFPPDVP---DVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWE 343

  Fly   376 NIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDS 440
            .:....|||:||:..|.|||||||||:.:....::||.::.||||.||||:|||::..|.|
Human   344 RLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHS---- 404

  Fly   441 KKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFER 505
                                    |.::||.      ..||..:|..|:|||.|||::|.|...
Human   405 ------------------------PESSSEA------WAALERKLQCLEQEKVELSRKHQEALH- 438

  Fly   506 LKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKE--EELD----GAMQKNDS 564
                             |..::.|:.:...|::..:.:|...:|||.  .:.|    |:..::..
Human   439 -----------------APTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSD 486

  Fly   565 LRNELRKSDKTRRELELHIEDAVIEAAKEKKL---REHAEDCCRQLQMELRKGSSSVETTMPLSI 626
            ||.||   |:..|||   .|......|:|::|   :...|:..::||....:.:::...|..||.
Human   487 LRQEL---DRLHREL---AEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSS 545

  Fly   627 SSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLA-----------------L 674
            ..|.:......||.|.| .||.|.|:...:.|...|:.|:.:..:.|                 |
Human   546 QLEEARAAQRELEAQVS-SLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQL 609

  Fly   675 TKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED 739
            .||:...:|:|:.......:...|.|.:|::    |......|::||.:|:..:.:|.:.|:.|
Human   610 RKEVAALREQLEQAHSHRPSGKEEALCQLQE----ENRRLSREQERLEAELAQEQESKQRLEGE- 669

  Fly   740 DEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKHVG--TFNNNGV 802
                     :||..:.||.|:|:|:.||:|||.:|||||||||||.||||.|::||  |.....:
Human   670 ---------RRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPL 725

  Fly   803 DNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILH 867
            |:: |:.||.||::....|.|||||:.||:||..:.:.|:|.:...:..::.:::.:|:..::..
Human   726 DHQ-WKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQ 789

  Fly   868 DFQKKETELRDLQKGGLEYSES-----FLN-KSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGD 926
            :......|||  .:|.::...|     ||: :|:.        :|.:|:..|...|...|.|  .
Human   790 ELAMLREELR--ARGPVDTKPSNSLIPFLSFRSSE--------KDSAKDPGISGEATRHGGE--P 842

  Fly   927 NFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSRE-----ESDQLVKESQKKVPGN 986
            :..|...:|...|.:|...|           :...||...|..:     ..:.|........||:
Human   843 DLRPEGRRSLRMGAVFPRAP-----------TANTASTEGLPAKGWGMGPWEALGNGCPPPQPGS 896

  Fly   987 TAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLG 1051
               |....|:|.|||||..|||||:||.|||:.|:.||:.|||.|..:.| .||||.|..:..||
Human   897 ---HTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAP-PCPVPPDLLRTALG 957

  Fly  1052 IDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPD-RCALPSVSVSQVLDMRD 1115
            :.|..|.||||||::.||:...::|||.|.|..:.|.:|.|:| :|| |.:.||.::.||||:||
Human   958 VHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFD-APDLRLSPPSGALLQVLDLRD 1021

  Fly  1116 PEFSVGSVRESDVIHAAKKDVPCIFKIKTA-LIDGGLSLNTLMLADNESEKSKWVIALGELHRIL 1179
            |:||...|..||||||..:|:|.||::.|: |.....:...|:||::|.|:.:|:..||||.|:|
Human  1022 PQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLL 1086

  Fly  1180 KRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKI 1244
            .........::.:.|..||.|.|:.:.||:.|:..:::.||||:|||.|:|...:|.::||.:::
Human  1087 LDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRV 1151

  Fly  1245 LQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGII--RRFPNIVYS 1307
            .||.......:||:|||:..::||..:..||..:|...|:.||:.|.....|.|  .|.|.:
Human  1152 QQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVL--- 1213

  Fly  1308 FIIALKRPNNHTQIVVYEIN------RTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTA 1366
             .:|:||     |::.|::.      :.|.|     |.......|.|.:|.| ||.|....||..
Human  1214 -CVAVKR-----QVLCYQLGPGPGPWQRRIR-----ELQAPATVQSLGLLGD-RLCVGAAGGFAL 1266

  Fly  1367 YFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFG-----------EYLLVFQTL 1420
            |.|..||..::|                .|..|.|.|.||.|..|           |:||:|.|.
Human  1267 YPLLNEAAPLAL----------------GAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTA 1315

  Fly  1421 AIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNL 1485
            .||||..|||||..|:::||.|....:...:|.|||:..:|:|:.:.|||||::.||:..|||..
Human  1316 GIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPE 1380

  Fly  1486 GNVVLSSVNDTPLIVYLSNIHTK----GLLQYRDGNRKGL--PSIKRRFSIREINKTIKSDR--- 1541
            |::.|.......| .||.|...:    .:....|.:|:.|  ...||||..|...:..|..|
Human  1381 GSLFLYGTEKVRL-TYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREM 1444

  Fly  1542 ------RSKMISAPTNFNHISHMGPGDG 1563
                  |||:||.||||||:.|:||.:|
Human  1445 LKDPFVRSKLISPPTNFNHLVHVGPANG 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	217/331 (66%)
		S_TKc	100..369	CDD:214567	184/268 (69%)
		KELK	478..556	CDD:292424	19/79 (24%)
		CEP63	492..749	CDD:293650	62/282 (22%)
		CEP63	652..880	CDD:293650	73/246 (30%)
		C1_1	990..1040	CDD:278556	26/49 (53%)
		PH_MRCK	1049..1182	CDD:269949	60/134 (45%)
		CNH	1211..1486	CDD:279162	97/293 (33%)
		CRIB	1544..1580	CDD:238077	13/20 (65%)
CDC42BPG	XP_011543457.1	STKc_DMPK_like	69..399	CDD:270748	218/332 (66%)
		S_TKc	71..337	CDD:214567	184/268 (69%)
		TPH	410..802	CDD:290579	122/439 (28%)
		DMPK_coil	744..801	CDD:117396	15/58 (26%)
		C1_1	897..>939	CDD:278556	24/41 (59%)
		PH_MRCK	956..1088	CDD:269949	60/132 (45%)
		CNH	1115..1378	CDD:279162	96/293 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3484
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1170	1.000	Inparanoid score	I202
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm42112
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880