DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and stk38l

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_001006753.1	Gene:	stk38l / 448427	XenbaseID:	XB-GENE-5881027	Length:	464	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	175/467 - (37%)
Similarity:	253/467 - (54%)	Gaps:	71/467 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CILSDTTSDQKWAAEF------------GEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVS 77
            |.:|..|.::...|:.            .|:.|..|..|:..::...:..||......:..:..:
Frog    11 CPMSSHTRERVTVAKLTLETFYSNLILQHEERETRQKKLEVAMEEEGLGDDEKKMRRSQHARKET 75

  Fly    78 DFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAET 142
            :||:|        ::.||..:||:.||:|||||||||.:||...|..:||||||.|.:||::.:.
Frog    76 EFLRL--------KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQV 132

  Fly   143 ACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITE 207
            |..|.|||:||..|..|:..:.|:|||..||||:|::..|||::|||.| :|.|.|:..:|||.|
Frog   133 AHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEATQFYIAE 196

  Fly   208 MILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDK----------------DGTVQ 256
            .:|||::|||:.::||||||||:|||.:|||:|:|||.|..|.|                |.:.|
Frog   197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQ 261

  Fly   257 ------------------SNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGET 303
                              :...|||||||:||:.  |:.|   |...||||||||.|||||.|..
Frog   262 NMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVIMYEMLIGYP 321

  Fly   304 PFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPW 368
            ||.:|:..|||.|:||.:.....|.:    ...||.|:||:.:.....|||:|.||:::...||:
Frog   322 PFCSETPQETYRKVMNWKETLVFPPE----VPTSEKSKDLILRFCADSENRVGSNGVEEIKSHPF 382

  Fly   369 FVGIDWKNIRQGPAPYVPEVSSPTDTSNFD-VDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF-- 430
            |.|:||.:||:.||....|:.|..|||||| ..::|:......||  .|.:......|:.:|:
Frog   383 FEGVDWGHIRERPAAIPIEIKSIDDTSNFDEFPESDILQPVLNPP--EPDYKSKDWVFLNYTYKR 445

  Fly   431 --SLTSSSTLDS 440
              .||...::.|
Frog   446 FEGLTQRGSIPS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	156/366 (43%)
		S_TKc	100..369	CDD:214567	134/302 (44%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
stk38l	NP_001006753.1	STKc_NDR2	87..452	CDD:270776	159/376 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010