DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gek and stk38a

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_998621.1	Gene:	stk38a / 406765	ZFINID:	ZDB-GENE-040426-2811	Length:	468	Species:	Danio rerio

Alignment Length:	486	Identity:	187/486 - (38%)
Similarity:	266/486 - (54%)	Gaps:	85/486 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SEISDITTGSCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSL 70
            |.:|:.|    |:|:|..|..|.:..|:   .....|:.|..|..|:.::|. ..|.||  ...|
Zfish    10 SSMSNHT----KERVTMAKVTLENFYSN---LISQHEEREMRQQKLEKVMDQ-EGLADE--EKRL 64

  Fly    71 RREKGV---SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILN 132
            ||.:..   ::||:|        ::.||..:||:.||:|||||||||.:||...|..|||||||.
Zfish    65 RRSEHARKETEFLRL--------KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILR 121

  Fly   133 KWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLP 197
            |.:||::.:....|.|||:||..|..|:..:.|:|||.:||||:|::..|||::|||.| :|.|.
Zfish   122 KADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKMNLYLIMEFLPGGDMMTLLMK-KDTLT 185

  Fly   198 EDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDK----------- 251
            |:..:|||.|.:|||:||||:.::||||||||:|||.||||:|:|||.|..|.|
Zfish   186 EEATQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSRGHVKLSDFGLCTGLKKAHRTEFYRNLN 250

  Fly   252 -----DGTVQSN------------------VAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGV 293
                 |.|.|:.                  ..|||||||:||:.  |::|   |...||||||||
Zfish   251 HSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQNG---YNKLCDWWSLGV 310

  Fly   294 CMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQN 358
            .|||||.|..||.:|:..|||.|:||.:.....|.:    ..:||.::||:.:..|..|:|:|..
Zfish   311 IMYEMLIGYPPFCSETPQETYRKVMNWRETLIFPPE----VPISEKAKDLILRFCCEGEHRIGAT 371

  Fly   359 GIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFD-VDDNDVRLTDSIPPSANPAFSGFH 422
            |:::...:.:|.|:|:.:||:.||....|:.|..|||||| ..|:|:     :.|||....|. |
Zfish   372 GVEEIKTNAFFEGVDYDHIRERPAAIPIEIKSIDDTSNFDEFPDSDI-----LQPSATTVVSN-H 430

  Fly   423 LP---------FIGFTF----SLTSSSTLDS 440
            ..         ||.:|:    .||:...:.|
Zfish   431 TEADLKSKDWVFINYTYKRFEGLTARGGIPS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	158/375 (42%)
		S_TKc	100..369	CDD:214567	133/302 (44%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
stk38a	NP_998621.1	STKc_NDR1	87..464	CDD:270777	162/391 (41%)
stk38a	NP_998621.1	S_TKc	89..382	CDD:214567	133/302 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920