Protein Alignment gek and rock2a

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: XP_068081021.1
• Gene: rock2a / 317747
• ZFINID: ZDB-GENE-030115-3
• Length: 1463
• Species: Danio rerio
• Alignment Length: 1398
• Identity: 379/1398 - (27%)
• Similarity: 606/1398 - (43%)
• Gaps: 424/1398 - (30%)

  Fly    17 KKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLK 81
            :.||..|:.::.|..|               ..:|:.|||:...|..:....:||:.|.:.:||.
Zfish    10 ENRLRQLEAMIKDPRS---------------AINLESLLDSMNALVLDLDFPALRKNKNIENFLN 59

  Fly    82 LSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFR 146
            ..:..::.:|:|::..:|||.:|:|||||||||.:|:..:::||||||:|:|:||:||:::|.|.
Zfish    60 RYEKVMNHIRELQMRPEDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFW 124

  Fly   147 EERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILA 211
            ||||::.|.|..|:..|..||||:.:||:||:|..||||:.|.|.::  :||..||||..|::||
Zfish   125 EERDIMAFADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVNLTSTYD--VPEKWAKFYTAEVVLA 187

  Fly   212 INSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAME 276
            :::||.:.::|||:||||:|||:.||::|||||:|:::|..|.|..:.|||||||||||:|:: :
Zfish   188 LDAIHSMGFIHRDVKPDNMLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKS-Q 251

  Fly   277 DGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQ 341
            .|.|.||.||||||:||.:||||.|:|||||:|||.||.|||:|:|..|.|.    :.::|:..:
Zfish   252 GGDGYYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPD----DVEISQEGK 312

  Fly   342 DLLCKLICIPENRLGQNGIQDFMDHPWFVGIDW--KNIRQGPAPYVPEVSSPTDTSNFDVDDNDV 404
            :::|..:...|.|||::|:::...||:|....|  ..||:..||.|||:||..||||||..:.|.
Zfish   313 NIICAFLTDREVRLGRSGVEEIKRHPFFRNDQWTFSTIRETAAPVVPELSSDIDTSNFDEIEEDK 377

  Fly   405 RLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQ------SSGFGDDTLDTISSPQLAI 463
            ...::.|  ...||.|..|||:|||:         .|:||      ||...:|.
Zfish   378 GEVETFP--TPKAFVGNQLPFVGFTY---------FKENQLLNAVNSSAMKNDH----------- 420

  Fly   464 LPSNNSETPVDSV----QLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAIS------ 518
             |.:|.|   |::    :|..|.:||....|.|.||.:::.....||:....||.:.::
Zfish   421 -PVSNRE---DNLALQKKLHCLEEQLNNEMQAKDELEQKYRSNSNRLEKITKELDEEMNSRKGLE 481

  Fly   519 ------QRNIAMMEYSEVT--EKLSELRNQKQKLSRQVRDKEEELDGAMQKNDS----------- 564
                  :|..|::::..|.  .:.....::|:.|..:|....::||...:||.:
Zfish   482 STLRQLEREKALLQHKSVESHRRAESEADRKRCLENEVNSLRDQLDEMKKKNQNSHISNEKNIHL 546

  Fly   565 ----------LRNE------LRK----SDKTRRELELHI-------------------EDAVIEA 590
                      ||.|      :||    |.|..::||.|:                   |:..::|
Zfish   547 QKQLDEANALLRAESEVATRMRKTQTESSKQLQQLEAHVRELQDKCCMLENSKLTLERENISLQA 611

  Fly   591 AKEKKLREH------------------------------AEDCCRQLQ-----MELRKGSSSVET 620
            |.:.:.||.                              ||...||||     ||..|.::.::.
Zfish   612 ALDTEKREQTQGSETISDLQARITGMEDEVRQMRQALSKAETEKRQLQEKLTDMEKEKSNNQIDM 676

  Fly   621 TMPLSI--------------------SSEMSSYEIE--------RLELQFSEKLSHQQTRHN--- 654
            |..|.:                    ...|.|..||        .||.:..|:.|.:|...|
Zfish   677 TYKLKMLQQGLEQEEAAHKATKARLADKNMISESIEGAKSEAVKELEQKLQEERSSKQRVENRVL 741

  Fly   655 -----------------MELEALREQ----FSELENANLALTKELQQ---TQERLKY--TQMESI 693
                             .:||.||..    ..|::|.||.:.:|:|:   ||..||.  .|:.::
Zfish   742 ELEKKNSMLDCDYKQSLQKLEELRRHKERLTEEVKNLNLKIEQEVQKRTLTQNDLKVQNQQLSTL 806

  Fly   694 TDSAETL------------------LELKK------------QHDLEKSSWF------------- 715
            ..|.:.|                  :||:|            |..||...:|
Zfish   807 RTSEKQLKQEINHILEIKRSLEKQNMELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKE 871

  Fly   716 --EEKQRLSSEVNLKSKSLKELQAEDD---------------------------------EIFKE 745
              |||.:|..:|   .::|:|||.|.|                                 :|.||
Zfish   872 ECEEKNKLYKDV---QQNLQELQEERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKE 933

  Fly   746 LRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNR 810
            |.:| |.:....:::||....:|..::|...|.:....:..|.|      .|||...:.:::  .
Zfish   934 LEIK-EMMARHRQELAEKDTTISSLEEANRTLTSDVANLANEKE------EFNNKLKEAEDY--L 989

  Fly   811 RSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETE 875
            ::.|.::..:..::.||::::|::..:..:.....::::: :||||....|..:.. |.::||.|
Zfish   990 QNLKNEEQSITQVKLALEKQLQSERTLKTQAVNKLAEIMN-RKEVRGGGSRRGNDT-DVRRKEKE 1052

  Fly   876 LRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGM 940
            .|.||   ||.      :|....|          ||.||
Zfish  1053 NRKLQ---LEL------RSEREKL----------NSTII-------------------------- 1072

  Fly   941 LFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNH 1005
                  ||            :..::|:..    ||:.|||.::....|:.       |..:....
Zfish  1073 ------KY------------QREINDIQA----QLLDESQVRIELQMALD-------SKDSDIEQ 1108

  Fly  1006 CTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPK 1070
            ..||:..|..|.:              .....:....||..:..|.|        ..||::.:|.
Zfish  1109 LRSLLNSLNVQSL--------------DSASMSSGPDMDTDESLLEI--------RLEGWLSLPV 1151

  Fly  1071 SGVIKR-GWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKK 1134
            ....|| ||.|::|||...|:..|:...|:   ...:...|||: |..|.|.||.::||..|..|
Zfish  1152 RNNTKRFGWERKYVVVSSKKILFYNSEQDK---EHSNPYMVLDI-DKLFHVRSVTQTDVYRADAK 1212

  Fly  1135 DVPCIFKIKTALIDGGLSLNTLMLADNESEKSK 1167
            ::|.||:|               |..||.|..|
Zfish  1213 EIPRIFQI---------------LYANEGESKK 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	165/333 (50%)
		KELK	477..556	CDD:464876	18/92 (20%)
		CCDC158	<481..>894	CDD:464943	126/646 (20%)
		C1_MRCK	990..1042	CDD:410359	5/51 (10%)
		PH_MRCK	1049..1182	CDD:269949	37/120 (31%)
		CNH	1215..1484	CDD:459938
		CRIB	1544..1580	CDD:238077
rock2a	XP_068081021.1	STKc_ROCK2	25..403	CDD:270771	179/410 (44%)
		SMC_prok_B	<430..1117	CDD:274008	145/774 (19%)
		HR1_ROCK2	491..557	CDD:212028	9/65 (14%)
		ROCK_SBD	842..922	CDD:409019	15/82 (18%)
		PH_ROCK	1141..1246	CDD:269948	36/117 (31%)
		C1_ROCK2	1239..1309	CDD:410425
		C1	1388..1452	CDD:412127