DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and Lats1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_001128015.2	Gene:	Lats1 / 308265	RGDID:	1564085	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	145/409 - (35%)
Similarity:	228/409 - (55%)	Gaps:	73/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAE 141
            |::::|        ::.::.:..|..:|.:|.|||||||:.:.:.|:.:||.|.|.|.::|.|.:
  Rat   690 SNYIRL--------KRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQ 746

  Fly   142 TACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYIT 206
            .|..:.|||:|...|.:|:..|:|:|||..|||.||||..|||:::||.:. ...||::|:|||.
  Rat   747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPENLARFYIA 810

  Fly   207 EMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCL------------------------ 247
            |:..|:.|:|::.::||||||||:|:|:.||::|.|||.|.
  Rat   811 ELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDF 875

  Fly   248 -----------------RLDKDGTVQ-----SNVAVGTPDYISPEILRAMEDGKGRYGTECDWWS 290
                             .|::....|     ::..||||:||:||:|  :..|   |...|||||
  Rat   876 SSEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVL--LRTG---YTQLCDWWS 935

  Fly   291 LGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRL 355
            :||.::|||.|:.||.|::.:||..|::|.|...::|.|.    |:|..:.||:.||...||:||
  Rat   936 VGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQA----KLSPEASDLIIKLCRGPEDRL 996

  Fly   356 GQNGIQDFMDHPWFVGIDW-KNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTD-SIPPSANPAF 418
            |:||..:...||:|..||: .::||..|.|:|:::.||||||||..|.|...:| :...:.|...
  Rat   997 GKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGNEEENINDTL 1061

  Fly   419 SGFHL-------PFIGFTF 430
            :|::.       .|..|||
  Rat  1062 NGWYKNGKHPEHAFYEFTF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	141/386 (37%)
		S_TKc	100..369	CDD:214567	118/314 (38%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
Lats1	NP_001128015.2	UBA_like_SF	103..143	CDD:419673
		PHA03247	<183..590	CDD:223021
		STKc_LATS1	703..1084	CDD:270775	143/388 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920