DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gek and Lats2

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:NP_001100737.1 Gene:Lats2 / 305922 RGDID:1305906 Length:1042 Species:Rattus norvegicus


Alignment Length:462 Identity:161/462 - (34%)
Similarity:238/462 - (51%) Gaps:124/462 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 VLYDECSN-SSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTE 123
            :||.:.|| :.|:|.|                    :.:..|..:|.:|.|||||||:...:.|.
  Rat   605 ILYQKESNYNRLKRAK--------------------MDKSMFVKIKTLGIGAFGEVCLACKVDTH 649

  Fly   124 KVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTL 188
            .:||||.|.|.::|.|.:.|..:.|||:|...|.:|:..|:|:|||..:||.||||..|||:::|
  Rat   650 ALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSL 714

  Fly   189 LSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSC------- 246
            |.:.| ..||.:|:|||.|:.|||.|:|::.::||||||||:|:|..||::|.|||.|       
  Rat   715 LIRME-VFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTH 778

  Fly   247 ----------LRLD--KDGTVQSNVA---------------------------VGTPDYISPEIL 272
                      :|.|  :.|.:..:|:                           ||||:||:||:|
  Rat   779 NSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVL 843

  Fly   273 RAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVS 337
            ..    || |...|||||:||.::|||.|:.||.|.:..||..|::|.:|..::|:|    .|:|
  Rat   844 LR----KG-YTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQ----VKLS 899

  Fly   338 ETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDW-KNIRQGPAPYVPEVSSPTDTSNFD-VD 400
            ..::||:.||.|..:.|||::|..|...||:|..||: ::||:.||||||.:|.|.|||||| ||
  Rat   900 AEARDLITKLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVD 964

  Fly   401 DNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILP 465
            :                                     :|..:::||......||::||      
  Rat   965 E-------------------------------------ESPWHEASGESAKAWDTLASP------ 986

  Fly   466 SNNSETP 472
              ||:.|
  Rat   987 --NSKHP 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 144/379 (38%)
S_TKc 100..369 CDD:214567 123/314 (39%)
KELK 478..556 CDD:292424
CEP63 492..749 CDD:293650
CEP63 652..880 CDD:293650
C1_1 990..1040 CDD:278556
PH_MRCK 1049..1182 CDD:269949
CNH 1211..1486 CDD:279162
CRIB 1544..1580 CDD:238077
Lats2NP_001100737.1 UBA_LATS2 101..141 CDD:270581
PHA03247 <143..490 CDD:223021
PKc_like 624..1004 CDD:419665 154/423 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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