DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and bzz1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_596017.1	Gene:	bzz1 / 2539679	PomBaseID:	SPBC12C2.05c	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	802	Identity:	158/802 - (19%)
Similarity:	262/802 - (32%)	Gaps:	262/802 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 ELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGA 558
            |..|..:|:.:..|..||.:.:.........:.|.|.:....|...:...||.:..:|:.....|
pombe     4 ETYKFSDELHDDFKVVDSWINNGAKWLEDIQLYYKERSSIEKEYAQKLASLSNKYGEKKSRKSSA 68

  Fly   559 MQKNDS------------------LRNELRKSDKTRRELELHIEDAVIE-AAKEKKLREHAEDCC 604
            :...|:                  :.:||.:|.||.::|.   :|..:: |.|.|||..|.| ..
pombe    69 LSVGDTPAMSAGSLECASLTTWSKILDELTRSSKTHQKLS---DDYSLDIAEKLKKLESHIE-AL 129

  Fly   605 RQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELEN 669
            |::..:|.|..||.:.|:..|:.....||              |:...   :||:.|::..:...
pombe   130 RKVYDDLYKKFSSEKETLLNSVKRAKVSY--------------HEACD---DLESARQKNDKYRE 177

  Fly   670 ANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKE 734
                     |:||..||.::.:        :|:.|.::.|....:...||:..:|.  ....|..
pombe   178 ---------QKTQRNLKLSESD--------MLDKKNKYLLRMLVYNAHKQKFYNET--LPTLLNH 223

  Fly   735 LQAEDDEIFKELRMKREAITLWERQMAEIIQW---VSDEKDARGYLQALATKMTEEL---EYLKH 793
            :|     :..|.|:.         .:.||  |   .|.||.....|.....::..|:   |.:..
pombe   224 MQ-----VLNEYRVS---------NLNEI--WCNSFSIEKSLHDTLSQRTVEIQSEIAKNEPVLD 272

  Fly   794 VGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDY 858
            ...|..:  ::|||........:...:.:...||..:...||.:.:.|..:::||
pombe   273 SAMFGRH--NSKNWALPADLHFEPSPIWHDTDALVVDGSCKNYLRNLLVHSKNDL---------- 325

  Fly   859 KKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNE 923
                     ..||.|....|.|..||...:
pombe   326 ---------GKQKGELVSLDSQLEGLRVDD----------------------------------- 346

  Fly   924 SGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTA 988
                  ||   |.|.    ::|.|.|..|.:....|.:|.:.||  |.....:......:.....
pombe   347 ------PN---SANQ----SFESKKASINLEGKELMVKARIEDL--EVRINKITSVANNLEEGGR 396

  Fly   989 IHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTC----PVPMDQTKRP 1049
            .|.|...:|..||.|::|..::.||:::|.||:.|||.||..|...||..|    |...|.....
pombe   397 FHDFKHVSFKLPTSCSYCREIIWGLSKRGCVCKNCGFKCHARCELLVPANCKNGEPEVADDDAVD 461

  Fly  1050 LGI------DPTRGIGTAYEGY--------------------VKVPKS----------GVIKRGW 1078
            ..:      |.:.....|||.|                    ||..::          ||:
pombe   462 TSVTATDDFDASASSSNAYESYRNTYTDDMDSSSIYQTSLSNVKTEETTPAEPASKVDGVV---- 522

  Fly  1079 IRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIK 1143
                         |||.:.:...:.:.|..|...:.:|:...|.||                 :|
pombe   523 -------------LYDFTGEHEGVITASEGQEFTLLEPDDGSGWVR-----------------VK 557

  Fly  1144 TALIDG--GL----------SLNTLMLADNESEKSKWVIAL------------GELHRILKRNS- 1183
               |||  ||          .|||.:..|.:|...|.:.|.            |::.::..||:
pombe   558 ---IDGTDGLIPASYVKLNDELNTSVTLDGDSSYVKALYAYTAQSDMELSIQEGDIIQVTNRNAG 619

  Fly  1184 ------LPN--TAIFKVNEILD 1197
                  :.|  |..|..|.:.|
pombe   620 NGWSEGILNGVTGQFPANYVTD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748
		S_TKc	100..369	CDD:214567
		KELK	478..556	CDD:292424	12/61 (20%)
		CEP63	492..749	CDD:293650	56/273 (21%)
		CEP63	652..880	CDD:293650	42/233 (18%)
		C1_1	990..1040	CDD:278556	21/53 (40%)
		PH_MRCK	1049..1182	CDD:269949	32/192 (17%)
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
bzz1	NP_596017.1	FCH	6..107	CDD:214492	18/100 (18%)
		C1_1	398..447	CDD:278556	20/48 (42%)
		SH3_Bzz1_1	519..572	CDD:212845	17/89 (19%)
		SH3	588..640	CDD:302595	9/51 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	54	1.000	Domainoid score	I3226
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000