DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and STK38L

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_024304657.1	Gene:	STK38L / 23012	HGNCID:	17848	Length:	521	Species:	Homo sapiens

Alignment Length:	511	Identity:	177/511 - (34%)
Similarity:	258/511 - (50%)	Gaps:	125/511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KKRLTFLKCILSDTTSD---QKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGV-- 76
            ::|:|..|..|.:..|:   |.      |:.|..|..|:..::. ..|.||  ...|||.:..
Human    18 RERVTVAKLTLENFYSNLILQH------EERETRQKKLEVAMEE-EGLADE--EKKLRRSQHARK 73

  Fly    77 -SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRA 140
             ::||:|        ::.||..|||:.||:|||||||||.:||...|..:||||||.|.:||::.
Human    74 ETEFLRL--------KRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKE 130

  Fly   141 ETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYI 205
            :.|..|.|||:||..|..|:..:.|:|||..||||:|::..|||::|||.| :|.|.|:..:|||
Human   131 QVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYI 194

  Fly   206 TEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSC------------------------ 246
            :|.:|||::|||:.::||||||||:|||.:|||:|:|||.|
Human   195 SETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFC 259

  Fly   247 -----------LRLDKDGTVQS-------------------------------------NV---- 259
                       ||..::..|.|                                     |:
Human   260 KFGCCFSSFPWLRYCREQKVLSLSPLLNPLCFRCICIFFLWRAFFPRDYNSILLKLAFQNMNSKR 324

  Fly   260 ---------------AVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAES 309
                           .|||||||:||:.  |:.|   |...||||||||.|||||.|..||.:|:
Human   325 KAETWKKNRRQLAYSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVIMYEMLIGYPPFCSET 384

  Fly   310 LVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDW 374
            ..|||.|:||.:.....|.:    ..:||.::||:.:.....|||:|.:|:::...||:|.|:||
Human   385 PQETYRKVMNWKETLVFPPE----VPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDW 445

  Fly   375 KNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF 430
            ::||:.||....|:.|..|||||| |..:..:...:|.:..|.:......|:.:|:
Human   446 EHIRERPAAIPIEIKSIDDTSNFD-DFPESDILQPVPNTTEPDYKSKDWVFLNYTY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	155/422 (37%)
		S_TKc	100..369	CDD:214567	133/359 (37%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
STK38L	XP_024304657.1	STKc_NDR2	87..509	CDD:270776	156/425 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920