DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and Cdc42bpa

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_017175608.1	Gene:	Cdc42bpa / 226751	MGIID:	2441841	Length:	1810	Species:	Mus musculus

Alignment Length:	1765	Identity:	755/1765 - (42%)
Similarity:	1065/1765 - (60%)	Gaps:	246/1765 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGR 108
            |.|..||::.|||..|.|||||:||.|||||.:.::|:.:|||...|:::||.|:||:|||:|||
Mouse    21 TNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGR 85

  Fly   109 GAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINL 173
            ||||||.||::.:.:||:|||||||||||||||||||||||||||.||.:|||.|||||||:.||
Mouse    86 GAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNL 150

  Fly   174 YLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHV 238
            |||||||.|||||||||||||:|||:||:||:.||::||:|:||:.||||||||||:|:|..||:
Mouse   151 YLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHI 215

  Fly   239 RLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGET 303
            |||||||||:|.:||||||:||||||||||||||:||||||||||.|||||||||||||||||||
Mouse   216 RLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGET 280

  Fly   304 PFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPW 368
            |||||||||||||||||:..|..|:|.|   .|||.::||:.:|||..|:|||||||:||..||:
Mouse   281 PFYAESLVETYGKIMNHKERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPF 342

  Fly   369 FVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLT 433
            |.||||.|||...|||:||||||||||||||||:.::.::::||..:.||||.||||:|||:  |
Mouse   343 FSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTY--T 405

  Fly   434 SSSTLDSKKNQSSGFGDDTLD-------------------------------------------- 454
            ||..|..:.......|..:||
Mouse   406 SSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKLELTRKLQESTQTVQ 470

  Fly   455 -----TISSPQLA-------------------ILPSNNSETPVDSV------------QLKALND 483
                 |:..|..|                   :...|:.|..::..            |:||...
Mouse   471 ALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEK 535

  Fly   484 QLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQV 548
            |:..|:||:.||:|:..:..||||.|..||:||..||.:||.|:.|:.|:|:||..|||||:|.|
Mouse   536 QIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600

  Fly   549 RDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRK 613
            ||||||:|..|||.:|||.|||::::.::|||:|.|..:.||:|:|||||.:|...:||:.|| :
Mouse   601 RDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENEL-E 664

  Fly   614 GSSSVETTMPLSISSEMSSYEIERLE-------LQFSEKLSHQQTRHNMELEALREQFSELENAN 671
            |....:.:....|.|.....||.:|:       :.:.|::|.::..|..|::.|:::..:.|...
Mouse   665 GLKQKQISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQ 729

  Fly   672 LALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVN-----LKSKS 731
            |||.||:...:::|:.|:.||.::..|...|.|:|::.||....||.::|:||::     .:|.|
Mouse   730 LALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLS 794

  Fly   732 LKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKH--V 794
            |:....|::  .|:|..|:|::..||.|:.||||||||||||||||||||:|||||||.|::  :
Mouse   795 LRNQHLEEE--VKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSL 857

  Fly   795 GTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYK 859
            ||    ...:..|:.||..|||....|.|||||..||:||..|.:||::.::..|.|:.:::|.:
Mouse   858 GT----RATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNILTECKLKDSE 918

  Fly   860 KRYDSILHDFQK--KETELRDLQKGGLEYSES------FLNKSTHHGLSSAFFRD--MSKNSEII 914
            |:...:|.:.::  |:||....:| |:|:.:|      |||..| ..|..  |.|  .|.:|.:|
Mouse   919 KKNLELLSEIEQLIKDTEELRSEK-GIEHQDSQHSFLAFLNTPT-DALDQ--FEDSLSSSSSSLI 979

  Fly   915 DSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLS--REESDQLVK 977
            |    |.::...:.||                  |.|..:         ::|.:  ...:..|.|
Mouse   980 D----FLDDRSPSCTP------------------ASKGRR---------IADCAPLPAHTPTLRK 1013

  Fly   978 ESQKKVPGNTAI------HQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVP 1036
               |..|.:|..      |||.|::|::||||:.||||||||.|||..||:|||:||..|..|.|
Mouse  1014 ---KGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAP 1075

  Fly  1037 TTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCA 1101
            |.||||.:|||.||||||.:|:||||||:|::||...:|:||.|...||||||||||||:..:.:
Mouse  1076 TVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKAS 1140

  Fly  1102 LPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDG-GLSLNTLMLADNESEK 1165
            .|:..:|||:||||.||||.||..||||||::||:||||::..:.:.. ....:.|||||:|:|:
Mouse  1141 QPTSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENER 1205

  Fly  1166 SKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINL 1230
            ||||..|.|||:|||:|...:.:::...|..|:||.||:....:.||...:|.||.|:|||.:::
Mouse  1206 SKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHV 1270

  Fly  1231 DQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACT 1295
            .:.||.|:|::|||.|:..|..:|::.::.|:.|::||.|:.||:..:.::.|:.|:|.|.:...
Mouse  1271 TKDEIVRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAA 1335

  Fly  1296 GIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAH 1360
            |.:|.  ..:....:|:||     |::.||:.:::|||:|..|..:....|.:.|.|: .|.|..
Mouse  1336 GKVRH--GALSCLCVAMKR-----QVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSE-HLCVGF 1392

  Fly  1361 QSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVD 1425
            ||||..|.|.||....:::|..:...:|:::..:||:..:||      :..||||.|.::.||.|
Mouse  1393 QSGFLRYPLNGEGGPCNMLHSNDHTLSFISHQPMDALCAVEI------SNKEYLLCFNSIGIYTD 1451

  Fly  1426 LQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVL 1490
            .|||:||.:|:|:||.|:...:...:|.|:|:..:|||:..:.||:|::.||:..|||..|::.|
Mouse  1452 CQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNL 1516

  Fly  1491 SSVNDTPLIVYLSNIHTKG----LLQYRDGNRKGLP---SIKRRFSIREINKTIKSDR------- 1541
            ..: :|..::|..|...:|    :.:..|.:||.:.   :.|||:|.|...:.....|
Mouse  1517 LGL-ETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDP 1580

  Fly  1542 --RSKMISAPTNFNHISHMGPGDGIQNQRLLDLP-------------------------TTLETA 1579
              |:|:||.|||||||:|||||||||..:.|.:|                         .|:.:|
Mouse  1581 EMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMPGFPYSPPHHHSGLISSPSNFEHIYHMTVTSA 1645

  Fly  1580 DQACSP----------------IIHSLSC---IPQSRKSNFLEQVDANSDDYGNDNIISRTPSPM 1625
            :|..||                ..||::.   .||..::.|...|...|       |....|.|.
Mouse  1646 EQFLSPESISPGSPPSLRSAPGTPHSVTLRNPRPQESRTVFSGSVSIPS-------ITKSRPEPG 1703

  Fly  1626 AS-SFMDGLS 1634
            .| |...|||
Mouse  1704 RSMSASSGLS 1713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	246/331 (74%)
		S_TKc	100..369	CDD:214567	206/268 (77%)
		KELK	478..556	CDD:292424	41/77 (53%)
		CEP63	492..749	CDD:293650	101/268 (38%)
		CEP63	652..880	CDD:293650	92/236 (39%)
		C1_1	990..1040	CDD:278556	31/49 (63%)
		PH_MRCK	1049..1182	CDD:269949	76/133 (57%)
		CNH	1211..1486	CDD:279162	94/274 (34%)
		CRIB	1544..1580	CDD:238077	22/60 (37%)
Cdc42bpa	XP_017175608.1	STKc_MRCK_alpha	4..412	CDD:270773	279/395 (71%)
		SbcC	<442..>941	CDD:223496	175/505 (35%)
		KELK	530..608	CDD:406277	41/77 (53%)
		C1_MRCKalpha	1027..1086	CDD:410414	36/58 (62%)
		PH_MRCK	1088..1222	CDD:269949	76/133 (57%)
		CNH	1248..1512	CDD:395630	94/277 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833265
Domainoid	1	1.000	439	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55765
Inparanoid	1	1.050	1179	1.000	Inparanoid score	I199
Isobase	1	0.950	-	0	Normalized mean entropy	S1690
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm44167
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790