DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and Cdc42bpb

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_006515826.1	Gene:	Cdc42bpb / 217866	MGIID:	2136459	Length:	1730	Species:	Mus musculus

Alignment Length:	1758	Identity:	741/1758 - (42%)
Similarity:	1044/1758 - (59%)	Gaps:	228/1758 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |.|.||..|:.:|.|           |........|::.|||..:.||.|||:|:|||:|.|::|
Mouse     2 SAKVRLKKLEQLLLD-----------GPWRNDSALSVETLLDVLVCLYTECSHSALRRDKYVAEF 55

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            |:.:|||..:|:.::|.|:||:|:|:|||||||||.||:|.:||::|||||||||||||||||||
Mouse    56 LEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||.||.||||.|||||||...||||||||.||||||||||||||||||||:|||.||:
Mouse   121 FREERDVLVNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:||||:.||||||||||||||..||:|||||||||:::.||||||:||||||||||||||:|
Mouse   186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 250

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSET 339
            ||||.|:||.||||||||||||||||||||||||||||||||||||:..|..||..|   .|||.
Mouse   251 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVT---DVSEE 312

  Fly   340 SQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDV 404
            ::||:.:|||..|.|||||||:||..|.:|.|::|:|||...|||:|:||||:|||||||||:.:
Mouse   313 AKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDML 377

  Fly   405 RLTDSIPPSANPAFSGFHLPFIGFTF-------------SLTSSSTLD----------------- 439
            |..:.:||.::..|||.|||||||||             |:|.|:||.
Mouse   378 RNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMTQSNTLTKDEDVQRDLENSLQIEA 442

  Fly   440 ---------------SKKNQSS------------GFGDDTLD--------TISSPQLAILPSNNS 469
                           |:|.|.|            ..|:...|        .:...:..:..||..
Mouse   443 YERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRL 507

  Fly   470 ETPVDSV------------QLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNI 522
            |..::..            :||.|..|....:|||.||.||..|..||||:|..||:||..||..
Mouse   508 ERQLEDTVTLRQEHEDSTHRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKR 572

  Fly   523 AMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAV 587
            |:.|:||:.|::||||:.|||:|||:||||||::.||||.||:|.:||||:|:|:|||..:|||.
Mouse   573 ALQEFSELNERMSELRSLKQKVSRQLRDKEEEMEVAMQKIDSMRQDLRKSEKSRKELEARLEDAA 637

  Fly   588 IEAAKEKKLREHAEDCCRQLQMELR----------KGSSSVETTMPLSISSEMSSYEIERLELQF 642
            .||:||:|||||:|..|:|::.||.          .|::|........|.|     |:|:..|.:
Mouse   638 AEASKERKLREHSESFCKQMERELEALKVKQGGRGPGAASEHQQEISKIRS-----ELEKKVLFY 697

  Fly   643 SEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQH 707
            .|:|..::..|.:|::.::::..:.|:..|||.||:...:::|:.::.|..::..|.:..:|.::
Mouse   698 EEELVRREASHVLEVKNVKKEVHDSESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGTVKDKY 762

  Fly   708 DLEKSSWFEEKQRLSSEVNLKSKSLKELQAE----DDEIFKELRMKREAITLWERQMAEIIQWVS 768
            :.|::..|:|.::|::|.......:.:|.|:    :||: ::|..|:|::..||.|:||||||||
Mouse   763 ERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDEL-QDLASKKESVAHWEAQIAEIIQWVS 826

  Fly   769 DEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQA 833
            |||||||||||||:|||||||.|:. .:..:..:| ..|:.|||||||....|.|||||:.||:|
Mouse   827 DEKDARGYLQALASKMTEELETLRS-SSLGSRTLD-PLWKVRRSQKLDMSARLELQSALEAEIRA 889

  Fly   834 KNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQ--KKETE----------LRDLQKGGLEY 886
            |.::.:||.:.:...::.:.::::.:.:...:|.:.|  :|..|          |.|.|....||
Mouse   890 KQLVQEELRKVKDSSLAFESKLKESEAKNRELLEEMQSLRKRMEEKFRADTGLKLPDFQDSIFEY 954

  Fly   887 SESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGK 951
               |......|.|:   |||                        :...|..|.:|..:|...:..
Mouse   955 ---FNTAPLAHDLT---FRD------------------------SLSSSSASSLLALWEDTSSAS 989

  Fly   952 NNKDHSSMKEASVS---DLSREESDQLVKESQK----KVPGNTAI---------HQFLVRTFSSP 1000
            :.:..:|..:.|.|   ..|.|:.:.:.:..|:    .:|...|:         |||.:::|.||
Mouse   990 DQETQASKMDLSPSVSVATSTEQQEDMARPQQRPSPVPLPSTQALAMAGPKPKAHQFSIKSFPSP 1054

  Fly  1001 TKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGY 1065
            |:|:|||||||||.|||..||:|.|:||..|....|..||:|.:|:|||||:|..|||||||:||
Mouse  1055 TQCSHCTSLMVGLIRQGYACEVCAFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGY 1119

  Fly  1066 VKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIH 1130
            |||||...:|:||.|.:.||||.||||||:...:...|.|..|||||:||.||:|.||..|||||
Mouse  1120 VKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVVASQVLDLRDEEFAVSSVLASDVIH 1184

  Fly  1131 AAKKDVPCIFKIKTALIDGGLSLNTLM-LADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNE 1194
            |.::|:||||::..:|:......::|: |.:||:||.|||..|..|..||.:|.|.:..:....|
Mouse  1185 ATRRDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLKSQVVHVAQE 1249

  Fly  1195 ILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVIL 1259
            ..|::|.||:..|.:.|:..::|.:|.|:||:.|.|.:..|.|..:.||:.|:....:|:|.::|
Mouse  1250 AYDSSLPLIKAVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKIAILL 1314

  Fly  1260 CGKQRNLRLLP---IRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQI 1321
            ||:..::.|.|   ....|||:.: ||:.|:|.|....||.:|:..:.  ...:|:||     .|
Mouse  1315 CGRNHHVHLYPWSSFDGAEASNFD-IKLPETKGCQLIATGTLRKSSST--CLFVAVKR-----LI 1371

  Fly  1322 VVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLC 1386
            :.|||.||:..|:|..|.......|.:.:..| ||.|.:.|||:...::|:...:.||:|.:...
Mouse  1372 LCYEIQRTKPFHRKFSELVAPGHVQWMAVFKD-RLCVGYPSGFSLLSIQGDGPPLDLVNPTDPSL 1435

  Fly  1387 AFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGH 1451
            |||:....||:..:|:      ...||||.|..:.:|||.|||:||.:|:|:||.|...:....|
Mouse  1436 AFLSQQSFDALCAVEL------KSEEYLLCFSHMGLYVDPQGRRSRMQELMWPAAPVACSCSPTH 1494

  Fly  1452 LLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKGLLQY--- 1513
            :.|:|:..:|:|:.:|.||||:|||::..|||:.|::.|... :.|.::|..|..:..:|..
Mouse  1495 VTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSDGSLNLLGC-EPPRLIYFKNKFSGTILNVPDT 1558

  Fly  1514 RDGNRKGL--PSIKRRFSIREINKTIKSDR-------------RSKMISAPTNFNHISHMGPGDG 1563
            .|.::|.:  ...||||    :.|..:.:|             ||||||.||||||::|||||||
Mouse  1559 SDNSKKQMLRTRSKRRF----VFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDG 1619

  Fly  1564 IQNQRLLDLP----TTLETADQACSPIIHSLSCIPQSRKSNFLEQVDANSDDYGNDNIISRTPSP 1624
            :  |.|:|||    .|::...|..:|.  .|...|.||...::....:...:.|       .|.|
Mouse  1620 M--QVLMDLPLSAAPTVQEEKQGPTPA--GLPRQPPSRSKPYVSWPSSGGSEPG-------VPVP 1673

  Fly  1625 MAS 1627
            :.|
Mouse  1674 LRS 1676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	247/331 (75%)
		S_TKc	100..369	CDD:214567	210/268 (78%)
		KELK	478..556	CDD:292424	44/77 (57%)
		CEP63	492..749	CDD:293650	102/270 (38%)
		CEP63	652..880	CDD:293650	83/243 (34%)
		C1_1	990..1040	CDD:278556	28/49 (57%)
		PH_MRCK	1049..1182	CDD:269949	71/133 (53%)
		CNH	1211..1486	CDD:279162	95/277 (34%)
		CRIB	1544..1580	CDD:238077	23/39 (59%)
Cdc42bpb	XP_006515826.1	STKc_MRCK_beta	3..411	CDD:270774	279/421 (66%)
		SbcC	429..>933	CDD:223496	175/511 (34%)
		KELK	527..606	CDD:374120	44/78 (56%)
		C1	1044..1093	CDD:237996	28/48 (58%)
		PH_MRCK	1103..1237	CDD:269949	71/133 (53%)
		CNH	1263..1529	CDD:366300	95/280 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833266
Domainoid	1	1.000	439	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1179	1.000	Inparanoid score	I199
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm44167
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840