DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and Rock2

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_036013163.1	Gene:	Rock2 / 19878	MGIID:	107926	Length:	1472	Species:	Mus musculus

Alignment Length:	1350	Identity:	366/1350 - (27%)
Similarity:	622/1350 - (46%)	Gaps:	326/1350 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            :::.|||....|..:....:||:.|.:.:||...:..|..:|.|::..:|:|::|:|||||||||
Mouse    42 NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV 106

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .:|:..:::||||||:|:|:||:||:::|.|.||||::.|.:..|:..|..||||:..||:||:|
Mouse   107 QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEY 171

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            ..||||:.|:|.::  :||..||||..|::||:::||.:..:|||:||||:||||.||::|||||
Mouse   172 MPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFG 234

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAES 309
            :|:::|:.|.|..:.|||||||||||:|:: :.|.|.||.||||||:||.::|||.|:|||||:|
Mouse   235 TCMKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADS 298

  Fly   310 LVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVG--I 372
            ||.||.|||:|:|....| ::|   ::|:.:::|:|..:...|.|||:||:::...||:|..  .
Mouse   299 LVGTYSKIMDHKNSLCFP-EDT---EISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQW 359

  Fly   373 DWKNIRQGPAPYVPEVSSPTDTSNF-DVDDN--DVRLTDSIPPSANPAFSGFHLPFIGFTF---S 431
            :|.|||:..||.|||:||..|:||| |::|:  ||. |..||    .||.|..|||||||:   :
Mouse   360 NWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVE-TFPIP----KAFVGNQLPFIGFTYFREN 419

  Fly   432 LTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELS 496
            |..|.:...::|.                 ||....:.|:.....:|.||.:.|::..|.|.||.
Mouse   420 LLLSDSPPCREND-----------------AIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELE 467

  Fly   497 KQHNEVFERLKTQDSELQDAIS------------QRNIAMMEY--SEVTEKLSELRNQKQKLSRQ 547
            ::...:..||:....||::.|:            :|..|::::  :|...|.....::|:.|...
Mouse   468 QKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLEND 532

  Fly   548 VRDKEEELDGAMQKNDS---------------------LRNE------LRK----SDKTRRELE- 580
            |...:::|:...::|.|                     ||.|      |||    |.|..::||
Mouse   533 VNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLES 597

  Fly   581 ----LHIEDAVIEAAK----------------EKKLREHAEDCC--------------------- 604
                |..::.::|.||                |::.|.|..:..
Mouse   598 NNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTGKALL 662

  Fly   605 -------RQLQ-----MELRKGSSSVETTMPLSI----------------------------SSE 629
                   ||||     :|..|.:..::.|..|.:                            ..|
Mouse   663 AKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEE 727

  Fly   630 MSSYEIERLELQFSEKLSHQQTRHNMELEA-------------LREQFSEL---------ENANL 672
            ..|..::.:|.:..|:.|.:|...|:.|||             .:::.:||         :..||
Mouse   728 AKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNL 792

  Fly   673 ALTKELQQTQER-LKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSE-VNLKSK----- 730
            .|..| |:||:| |....::..|....||...:||...|.:...|.|..|..: ..|:.:
Mouse   793 TLKIE-QETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNTELRKERQDAD 856

  Fly   731 -SLKEL--QAEDDEIF--------KELRMKREAITLWERQMAEIIQWVSDEKDA-RGYLQALATK 783
             .:|||  |.|.::.|        :||:.:.|..|...:::.:..|.:.||:|: ...|:...||
Mouse   857 GQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQLEITLTK 921

  Fly   784 M-TEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDK-MELLNLQSALQREIQAKNMISDELSQTRS 846
            . :|:|.          ..:..:.:.:...:|:.| :|:..:.:..::|:..|:.....|.:|..
Mouse   922 ADSEQLA----------RSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDTTIASLEETNR 976

  Fly   847 DLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGG----LEYSESFLNKSTHHGLSSAFFRDM 907
            .|.|....:.:.|:..::.|.|.|::.::|:|.:...    .::.:..||:.|   |.:   :.:
Mouse   977 TLTSDVANLANEKEELNNKLKDSQEQLSKLKDEEMSAAAIKAQFEKQLLNERT---LKT---QAV 1035

  Fly   908 SKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREE- 971
            :|.:||::..|.....|..:..                 :...:|.|.|..:|.      .||:
Mouse  1036 NKLAEIMNRKEPVKRGSDTDVR-----------------RKEKENRKLHMELKS------EREKL 1077

  Fly   972 SDQLVK------ESQKKVPGNTAIHQFLVRTFSSPTK-----CNHCTSLMVGL------TRQGVV 1019
            :.|::|      |.|.::...:.|...|..|..|...     .:...:|.:|:      :..|..
Mouse  1078 TQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDA 1142

  Fly  1020 CEICGFACH----------TICCQKVPTTCPVP---------------------MDQTKRPLGID 1053
            ....||..|          :...|:..|:..:.                     :..:..|:..:
Mouse  1143 EPDDGFPVHITQSHTMESMSFTYQRSSTSLSIATKPSSSHTLLDFDSEEDSLPYLPSSSEPISTE 1207

  Fly  1054 PTRGIGTAYEGYVKVP-KSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPE 1117
                  :..||::.:| ::...|.||::::|:|...|:..||...|:   ...:...|||: |..
Mouse  1208 ------SRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDK---EQSNPYMVLDI-DKL 1262

  Fly  1118 FSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSK 1167
            |.|..|.::||..|..|::|.||:|               |..||.|..|
Mouse  1263 FHVRPVTQTDVYRADAKEIPRIFQI---------------LYANEGESKK 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	170/336 (51%)
		S_TKc	100..369	CDD:214567	137/268 (51%)
		KELK	478..556	CDD:292424	20/91 (22%)
		CEP63	492..749	CDD:293650	82/423 (19%)
		CEP63	652..880	CDD:293650	59/270 (22%)
		C1_1	990..1040	CDD:278556	11/70 (16%)
		PH_MRCK	1049..1182	CDD:269949	32/119 (27%)
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
Rock2	XP_036013163.1	STKc_ROCK2	39..417	CDD:270771	183/386 (47%)
		Smc	<437..1101	CDD:224117	133/703 (19%)
		ROCK_SBD	856..936	CDD:409019	19/89 (21%)
		PH_ROCK	1208..1314	CDD:269948	31/108 (29%)
		C1_ROCK2	1307..1377	CDD:410425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780