DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gek and Rock1

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:NP_033097.1 Gene:Rock1 / 19877 MGIID:107927 Length:1354 Species:Mus musculus


Alignment Length:1261 Identity:368/1261 - (29%)
Similarity:606/1261 - (48%) Gaps:260/1261 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 DYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCV 116
            |.|||....|..:....:||:.|.:.:||...|..::.:|.||:..:|::::|:|||||||||.:
Mouse    28 DCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQL 92

  Fly   117 VQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYC 181
            |:..||.||||||:|:|:||:||:::|.|.||||::.|.:..|:..|.|||||:..||:||:|..
Mouse    93 VRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMP 157

  Fly   182 GGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSC 246
            ||||:.|:|.::  :||..|:||..|::||:::||.:.::|||:||||:||||.||::|||||:|
Mouse   158 GGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC 220

  Fly   247 LRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLV 311
            ::::|:|.|:.:.|||||||||||:|:: :.|.|.||.||||||:||.:||||.|:|||||:|||
Mouse   221 MKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLV 284

  Fly   312 ETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID--W 374
            .||.|||||:|....|...    .:|:.:::|:|..:...|.|||:||:::...|.:|....  |
Mouse   285 GTYSKIMNHKNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAW 345

  Fly   375 KNIRQGPAPYVPEVSSPTDTSNFD--VDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF-----SL 432
            :.:|...||.||::||..||||||  .:|.....|..||    .||.|..|||:|||:     .|
Mouse   346 ETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIP----KAFVGNQLPFVGFTYYSNRRYL 406

  Fly   433 TSSSTLDSKKNQSSGFGDDTLDTISSPQLAIL------------------PSNNSETPVDSV--- 476
            .|:   ::.:|:||...|.:|.  .|.|..|.                  ....|...:|.:   
Mouse   407 PSA---NASENRSSSNVDKSLQ--ESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKE 466

  Fly   477 ------QLKALNDQLAALKQEKAELS----------KQHNEVFERLKTQDSELQDAISQRNIAMM 525
                  |.:.|...::.:::||..|.          :|.||....::.:.|.|:|.:.....|..
Mouse   467 LDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQ 531

  Fly   526 EYSEVTEKLSELRNQKQKLSRQVRDKEE----------ELDGAMQKNDSL------RNELRKSDK 574
            ......|||::|:.|.::.:..:|.:.:          |:..::.:.:||      ||.:.::.|
Mouse   532 TSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596

  Fly   575 TRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLE 639
            ::.:.:.:...||:||  |::.|.|..:....||..:......|:     .:...:...|.||.|
Mouse   597 SQADKDYYQLQAVLEA--ERRDRGHDSEMIGDLQARITSLQEEVK-----HLKHNLERVEGERKE 654

  Fly   640 LQFSEKLSH-QQTRHNMEL----------EALREQFSELENANLALTKELQQTQE---------- 683
            .|  :.|:| ::.::|:|:          :.|.::.:|.:.....||.:.|..:|          
Mouse   655 AQ--DMLNHSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEME 717

  Fly   684 -RLKYTQMESITDSAETLLELKKQ-----HDLEKSS-----WFEEKQRLSSEV-----NLKSKSL 732
             :|| .:.|:...:...::|.:||     .||::|.     ..|.|:|:..||     .|:.:|.
Mouse   718 KKLK-EEREAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESN 781

  Fly   733 KEL--------QAEDDEIFK--ELRMKREAITLWER------QMAEI----------IQWVSDEK 771
            |.|        ||.:.:..|  |.:||:|..||.|.      ::|::          ::.:.|:.
Mouse   782 KRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL 846

  Fly   772 DARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRN-RRSQKL-DKMELLNLQ---------- 824
            :|..|...|.....:||:          ..::.||..| |:.|:| .:.|.|:.|          
Mouse   847 EAEQYFSTLYKTQVKELK----------EEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAES 901

  Fly   825 -----------------------SALQREIQAKNMISDELSQTRS----DLISTQKEVRDYKKRY 862
                                   |..::||..|:.....|.:|.|    |:...:||..:..:|.
Mouse   902 EQLARGILEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEMLRKENEELNERM 966

  Fly   863 DSILHDFQ-KKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGD 926
            .:...::: |||.|:.:| |...|     .|.||...|.:   :.::|.:||::..:        
Mouse   967 RTAEEEYKLKKEEEINNL-KAAFE-----KNISTERTLKT---QAVNKLAEIMNRKD-------- 1014

  Fly   927 NFTPNFFQSGNSGMLFNYEPKYAGKNN---KDHSSMKEASVSDLSREESDQLVKESQKKVPGNTA 988
                           |..:.|.|...:   |:..:.|.....:..||:.:|:|.:.||::  |..
Mouse  1015 ---------------FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKEL--NDM 1062

  Fly   989 IHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVP-MDQTKRPLGI 1052
            ..|.:       .:|.|...|.:.|..:  ..:|.......:......:....| .|:|...|  
Mouse  1063 QAQLV-------EECTHRNELQMQLASK--ESDIEQLRAKLLDLSDSTSVASFPSADETDGNL-- 1116

  Fly  1053 DPTRGIGTAYEGYVKVPKSGVIKR-GWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDP 1116
             |...|    ||::.||..|.||| ||.:|:|||...|:..|:...|:   ...|.|.|||: |.
Mouse  1117 -PESRI----EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDK---EQSSPSMVLDI-DK 1172

  Fly  1117 EFSVGSVRESDVIHAAKKDVPCIFKI 1142
            .|.|..|.:.||..|..:::|.||:|
Mouse  1173 LFHVRPVTQGDVYRAETEEIPKIFQI 1198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 166/335 (50%)
S_TKc 100..369 CDD:214567 138/268 (51%)
KELK 478..556 CDD:292424 18/97 (19%)
CEP63 492..749 CDD:293650 68/329 (21%)
CEP63 652..880 CDD:293650 67/329 (20%)
C1_1 990..1040 CDD:278556 6/49 (12%)
PH_MRCK 1049..1182 CDD:269949 36/95 (38%)
CNH 1211..1486 CDD:279162
CRIB 1544..1580 CDD:238077
Rock1NP_033097.1 STKc_ROCK1 2..406 CDD:270772 181/388 (47%)
S_TKc 76..338 CDD:214567 138/268 (51%)
Interaction with FHOD1. /evidence=ECO:0000250 368..727 79/377 (21%)
Smc <422..>1097 CDD:224117 142/739 (19%)
HR1_ROCK1 489..554 CDD:212029 13/64 (20%)
SHROOM3 binding. /evidence=ECO:0000269|PubMed:22493320 707..946 51/249 (20%)
Rho_Binding 949..1014 CDD:286056 18/73 (25%)
RHOA binding. /evidence=ECO:0000250 998..1010 3/14 (21%)
Auto-inhibitory. /evidence=ECO:0000250 1115..1354 36/95 (38%)
PH_ROCK 1119..1225 CDD:269948 34/88 (39%)
C1 1229..1283 CDD:237996
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1333..1354
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

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