DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and sax-1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_508627.5	Gene:	sax-1 / 180655	WormBaseID:	WBGene00004727	Length:	476	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	175/481 - (36%)
Similarity:	239/481 - (49%)	Gaps:	85/481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EFGEDTEGHQFSLDYLLDTFIVL-------YDECSNSSLRREK--------GVSDFLKLSKPFVH 88
            |...:.|..|::.|....|.|.:       ..:|:....|.:|        |:||..|..|..:|
Worm     3 EIAPEMEISQYTKDKASCTRISIESYYSKRVTQCAERENRLKKLEEDISARGLSDEEKEEKRKIH 67

  Fly    89 --------IVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACF 145
                    .:::.||:.:||:.||:|||||||||.:||...|..:||||||.|.||:::.:||..
Worm    68 HSKETDYLRLKRTRLTVNDFESLKVIGRGAFGEVRLVQKHDTGHIYAMKILRKSEMVEKEQTAHV 132

  Fly   146 REERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMIL 210
            |.|||:|...|..|:..::|:|||..||||||::..|||::|||.| :|.|.|:..:|||.|..|
Worm   133 RAERDILSEADCDWVVKMYYSFQDYSNLYLVMEFLPGGDMMTLLIK-KDTLTEEATQFYIAEAAL 196

  Fly   211 AINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDK------------------------ 251
            ||..||.:.::||||||||:|||.||||:|:|||.|..|.|
Worm   197 AIQFIHSLGFIHRDIKPDNLLLDARGHVKLSDFGLCTGLKKFHRTDHYRNWPSTLPPDFISKPFE 261

  Fly   252 ----------DGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFY 306
                      :....:...|||||||:||:.:     ...|...||||||||.|||||.|..||.
Worm   262 SKRKAETWKRNRRAYAYSTVGTPDYIAPEVFQ-----PNGYTKSCDWWSLGVIMYEMLIGYPPFC 321

  Fly   307 AESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQN-GIQDFMDHPWFV 370
            :|...|||.|::|.|.....||...::.:...|    :.:..|..|.|||.: |:.:....|:..
Worm   322 SELPQETYRKVINWQQTLVFPSDVPISIEAKAT----IKRFCCEAERRLGNHGGLDEIKQCPFVK 382

  Fly   371 GIDWKNIRQGPAPYVPEVSSPTDTSNF-DVDDNDVRLTDS--IPPSANPAFSGFHLPFIGFTFSL 432
            .|||.:||:.|.|....|.|..||||| |..|.|:....|  |.|...|...|   .|:.||:..
Worm   383 RIDWNHIRERPPPIRVTVKSIDDTSNFDDFPDEDLTWPTSTLIRPEEQPGRRG---EFVDFTYKR 444

  Fly   433 TSSST-----------LDSKKNQSSG 447
            ....|           ..:|||:..|
Worm   445 FDGLTQKMRYSDLKKFQQAKKNKKGG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	152/369 (41%)
		S_TKc	100..369	CDD:214567	127/303 (42%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
sax-1	NP_508627.5	STKc_NDR_like	85..443	CDD:270750	153/370 (41%)
sax-1	NP_508627.5	S_TKc	87..381	CDD:214567	127/303 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920