DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and mrck-1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_504599.2	Gene:	mrck-1 / 179013	WormBaseID:	WBGene00006437	Length:	1592	Species:	Caenorhabditis elegans

Alignment Length:	1733	Identity:	646/1733 - (37%)
Similarity:	946/1733 - (54%)	Gaps:	281/1733 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |...||..|:.|..|           |...:....|.:.|:|:.|.|||||.||:||:||.:::|
Worm     9 SAPVRLKTLENIYMD-----------GPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEF 62

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            ::..|..:...:|||||||||::||:||:||||||.||:|....::|||||||||||:|||||||
Worm    63 VESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETAC 127

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||:|||:|||||||||||..|||.|||||.|||:|||||||.|.:||.||||||.||:
Worm   128 FREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMV 192

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:|:|::.|||||:||||||||.:||:||||||||||:..||:|.||||||||||||||||||
Worm   193 LAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRA 257

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSET 339
            ||||:||||.||||||||:||||||||.||||:|.||:||||||:||:..:.|..| :::.|||.
Worm   258 MEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDE-IDWVVSEE 321

  Fly   340 SQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVD--DN 402
            ::||:.:|||..:.|.|:||:.||..||:|.||||..||....|||||||||.||||||||  ::
Worm   322 AKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCED 386

  Fly   403 DVR--LTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGF--------GDDTL---- 453
            |..  |.::.||....||:|.||||:||::  |..|.|...::.:...        ||..|
Worm   387 DFTPCLQETQPPRVLAAFTGNHLPFVGFSY--THGSLLSDARSLTDEIRAIAQRCQGDAELMEKS 449

  Fly   454 ----------------------DTISSPQLAILP----SNNSETPV----DSVQL--KALNDQLA 486
                                  .||.:..:|..|    ..|.|:.:    |.:|:  |.|.|:..
Worm   450 VDGFMVELENEKAELVQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQLKDEIQILNKRLEDEAL 514

  Fly   487 ALKQEK------AELSKQHNEVFER---LKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQ 542
            |.:|:|      ||..|:..|:.||   |..:.||:|          .|...:.:.|.::..:|.
Worm   515 AQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQ----------RELDNINDHLDQVLVEKA 569

  Fly   543 KLSRQVRDKEEEL----DGAMQKNDS---LRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHA 600
            .:.:|..|.:.||    |..:.:.||   |::|..|:.|...:.|..:::  ||..|...:::..
Worm   570 TVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKE--IETEKIALIKKQE 632

  Fly   601 EDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFS 665
            |     :.:|.||   ||||...||.....:...|..|:....|:        ..|::.|:::..
Worm   633 E-----VTIEARK---SVETDDHLSEEVVAAKNTIASLQATNEER--------ETEIKKLKQRMD 681

  Fly   666 ELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSK 730
            |...::.|      |:::.:|  |:|:..:.|:.:|    |.::|             ::|::::
Worm   682 EERASHTA------QSEQEMK--QLEAHYERAQKML----QDNVE-------------QMNVENR 721

  Fly   731 SLKELQAEDDEIFKELRMKREAIT---LWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLK 792
            .|:      ||| ::|..:..|:.   |.|:|:.||..|||:||..|..::.|..|:|.|:|.||
Worm   722 GLR------DEI-EKLSQQMAALPRGGLNEQQLHEIFNWVSEEKATREEMENLTRKITGEVESLK 779

  Fly   793 HVGTFNNNGVDNKN--------WRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLI 849
                 ||:.:...|        |.:||...:.:.:.|:||..||.||.||..:..||..::...:
Worm   780 -----NNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYL 839

  Fly   850 STQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHG-LSSAFFRDMSKNSEI 913
            ::...:.|.:||..|::     :|..:...||.....|:|..:.:...| |..:...|...::..
Worm   840 TSAARLDDTEKRMASLM-----REVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSS 899

  Fly   914 IDSAESFGNESGDNFTPNFFQSGNSGMLFNYE-PKYAGKNNKDHSSMKEAS-----VSDLSREES 972
            :...|....:|    ||::   .|:.:|.::: ||...........||.||     ||..:.|..
Worm   900 LMRQEMISRQS----TPSY---ENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERG 957

  Fly   973 DQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPT 1037
                             |.|......:||||.||||:::||.|||:.|:.|.:|||..|.::|..
Worm   958 -----------------HNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERVSQ 1005

  Fly  1038 TCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDR-CA 1101
            :|||| ::.:||||||||||:||||||.||.|::|.:::||...:||||||||:|||.:.|| ..
Worm  1006 SCPVP-EEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQNK 1069

  Fly  1102 LPSV--SVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALI-------DGGLSLNTLM 1157
            :..|  .:..|||||||:|:|..|.|:|||||.|.|:|.||::.|..|       .......||.
Worm  1070 MQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLF 1134

  Fly  1158 LADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILD-NTLSLIRNALCSVIIYPNQILLGT 1221
            :|:.|.||.|||:||.||..:|:|:.|.:...|.|.|:.| .||..||.|.|..||..::|::|.
Worm  1135 MAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLPSIRVAQCCAIIDRSKIVIGF 1199

  Fly  1222 ED-GLFYINLDQYEIARIGESKKILQ-----LWYIEEEQILVILCG--KQRNLRLLPIRALEASD 1278
            .| ||:.|.:.:..:..:|..|:..|     :.|.|.||:|:::.|  |.|::|::|..||:..|
Worm  1200 SDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDGRD 1264

  Fly  1279 VEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGY 1343
            ::||||.::|.|.....|.........: |.:|.|:     .:.:::|:|:..||:|..:..:..
Worm  1265 LKWIKVNDTKGCHLLAVGTNNPGGRAGF-FAVAFKK-----SVTIFQIDRSEKRHKKWKDLAMPG 1323

  Fly  1344 MAQHLQILSDMRLVVAHQSGFTAYFL---------RGEATA-----MSLVHPENQLCAFLN-YSG 1393
            ..|.:.|.:. ||.|.....|.::.|         .|:|:.     :|||:.|:....||| .:.
Worm  1324 TPQSIAIFNG-RLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTS 1387

  Fly  1394 VDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDT 1458
            .:|..::.:    .|:..||||||..:.:||:..||:||..|:|:|....|..:.:.:|.|||:.
Worm  1388 YEAKLIVNV----PGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSEN 1448

  Fly  1459 HLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSS--VNDTPLIVYLSNIHTKGLLQYRD------ 1515
            .:||||...|||||:|.|:.:.||:  |:.:||:  .||:|:.|.|.|:     ||.:|
Worm  1449 EVDIFNVTLAEWVQTINLRSAKPLS--GDGILSTCLCNDSPIFVLLQNV-----LQDQDSIEVPV 1506

  Fly  1516 ----GNRKGLPSIKRRFSIREINKTIK--SDRRSKM-ISAPTNFNHISHMGPGDGIQ-NQRLLDL 1572
                |:..|....:|:|:.|.|.|..:  |:|||.: ||.|::|.||.||||...:: .|..:||
Worm  1507 NLASGSTDGRKVTRRKFTFRTIGKDDRSASERRSHIQISTPSDFMHIVHMGPAPVMELQQNFIDL 1571

  Fly  1573 PTTLETADQACSPIIHSLSCIPQSRKSNFLEQVDANSDDYGND 1615
                                  ||..|:.....|:.:....||
Worm  1572 ----------------------QSNHSHTSSDKDSLNRSVNND 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	231/335 (69%)
		S_TKc	100..369	CDD:214567	192/268 (72%)
		KELK	478..556	CDD:292424	23/92 (25%)
		CEP63	492..749	CDD:293650	60/272 (22%)
		CEP63	652..880	CDD:293650	59/238 (25%)
		C1_1	990..1040	CDD:278556	22/49 (45%)
		PH_MRCK	1049..1182	CDD:269949	72/142 (51%)
		CNH	1211..1486	CDD:279162	90/297 (30%)
		CRIB	1544..1580	CDD:238077	13/37 (35%)
mrck-1	NP_504599.2	STKc_DMPK_like	81..417	CDD:270748	231/338 (68%)
		S_TKc	83..351	CDD:214567	192/268 (72%)
		COG1340	494..786	CDD:224259	88/356 (25%)
		C1	958..1007	CDD:237996	22/48 (46%)
		PH_MRCK	1016..1159	CDD:269949	72/142 (51%)
		CNH	1182..1494	CDD:214481	101/324 (31%)
		PBD	1544..1582	CDD:197628	16/59 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157475
Domainoid	1	1.000	396	1.000	Domainoid score	I379
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55765
Inparanoid	1	1.050	964	1.000	Inparanoid score	I157
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		oto18287
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10529
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840