Protein Alignment gek and citk-1

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: NP_496914.1
• Gene: citk-1 / 175043
• WormBaseID: WBGene00012198
• Length: 1256
• Species: Caenorhabditis elegans
• Alignment Length: 1440
• Identity: 271/1440 - (18%)
• Similarity: 512/1440 - (35%)
• Gaps: 453/1440 - (31%)

  Fly   184 DLLTLLSKFE----------DKLPEDMA-KFYITEMILAIN----SIHQIRYVHRDIK-PDNVLL 232
            ||.|.|.:.|          |.|.|.:. |..:.|.::...    |..:.|...||:. .::.|.
 Worm    38 DLKTRLLEAENIIQDLRSERDALHESLVDKAGLNESVIIERSNKVSTQETRIYRRDVTLLEDDLK 102

  Fly   233 DKRGHVRLADFGSCLRLDKD-GTVQSNVAVGTPDYISPEI--------LRAMEDGKGRYGTECDW 288
            .|...:|:.. ..||||:.: ..:|..::....|....||        |..:||
 Worm   103 QKESQIRILQ-NRCLRLETEKQKMQDTISGYQEDLKENEIRIENLNSRLHKLED----------- 155

  Fly   289 WSLGVCMYEML-YGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICI-P 351
             .|....:|:. .||         |...|.|                |::|.:.....||..| .
 Worm   156 -ELSAKTHEIFSIGE---------ELKNKTM----------------KLNEKNSQFQTKLAEISS 194

  Fly   352 ENRLGQNGIQDFMDHPWFVGIDWKNI-----RQGPAPYVPEVSSPTDTSNF----DVDDNDVRLT 407
            |||..:..:|.|.:.  .:..|.:::     ::.....:.||...:|..::    ..|.:.::..
 Worm   195 ENRNLERKVQKFREE--LIVKDQRSLEVHQDQENTQKVLKEVKQLSDRLDYLTPKRKDVSRIKER 257

  Fly   408 DSIPPSANPAFSGFHLPFIGFTFS--LTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSE 470
            |.        |..|....|..|.|  ...::.|:.:.::.     :.|..::..:|..|....::
 Worm   258 DD--------FLQFSAKIIEETMSELKLKNARLERELSEK-----EELVKVTKEELQELQKTVTQ 309

  Fly   471 TPVDSVQ-LKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKL 534
            ...||.| .|.|:.:...|.::||::.....|....||..|.:.::...||:.|:.:...:||..
 Worm   310 AMGDSEQATKYLHAENMKLTRQKADIRCDLLEARRNLKGFDEKREELEKQRDEALEDVRRITELK 374

  Fly   535 SELRNQKQKLSRQVRDKEEELDGAMQK----------NDSLRNELRKSDKTRRELELHIEDAVIE 589
            ..:..:.:.|.....::||::|....:          :::::|||.|:::...::..|:..|..:
 Worm   375 KNVEIELRSLKLLAEEREEQIDELKSRVAGYEVLRRDHEAVKNELAKAEEKLNKMGAHLVMADKQ 439

  Fly   590 AAKEKKLREHAE-------DCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLS 647
            ::..|.|:|.||       :.|.::...:|...:|:|
 Worm   440 SSHFKTLKETAEGSRRRAIEQCNEMVARIRGLEASLE---------------------------- 476

  Fly   648 HQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKK---QHDL 709
             .|.:...|||.::.:       |:...|:::..:|.::.|.:    |..|.|.:|.|   .|:
 Worm   477 -NQRKVEQELEMVKAE-------NVRQAKKIEFMKEEIQETHL----DYREELSKLAKGGGSHE- 528

  Fly   710 EKSSWFEEKQRLSSEVNLKSKSLKELQAED---DEIFKELRMKR-----EAITLWERQMAEIIQW 766
                  .:.|| .||:....|:::|::|::   .:|.:|:|..:     |.:.| .:.|||.|:.
 Worm   529 ------ADSQR-DSELRSAKKTIQEVKADNKKLQQILEEVRQNQSKVLEENVKL-RKGMAEAIEK 585

  Fly   767 VSD-------EKDARGYLQALA-------TKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDK 817
            :.:       .::|...||..|       .|:.|||:                   .:|.:.|:|
 Worm   586 IEEFKRNWHSSREAGERLQLEAKENEEKVLKVEEELQ-------------------EKRLEVLEK 631

  Fly   818 MELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEV--RDYKKRYDSI---------LHDFQK 871
            .||:|.   ||.:|..|.....:||: ||.|:||..||  ..|.:..:.:         |..:..
 Worm   632 EELVNY---LQSQINTKQTKQPKLSR-RSTLMSTISEVDTSTYVREVEEVRALEEQREELQAYLA 692

  Fly   872 KETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSG 936
            ::.::.||||     |.|..|.:|.  ::|....::||
 Worm   693 EKRKMADLQK-----SRSTANTTTL--ITSTTATEVSK--------------------------- 723

  Fly   937 NSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFL-VRTFS-S 999
             |....:|.|          ::|:.                    .:|     |::| .|.:| .
 Worm   724 -SACELSYPP----------ATMRH--------------------DIP-----HKWLEFRHYSVL 752

  Fly  1000 PTKCNHCTSLMVGLT--RQGVVCEICGFACHTICCQKVPTTCPVPMD-----QTKRPLGIDPTRG 1057
            ..||:.|   .||:|  .:...|..|....|..|..:|..||.:|..     |..:.:|     |
 Worm   753 SMKCSLC---FVGITFFTKANKCSHCDVRVHASCAPRVNNTCGIPAQCATYYQDAQAVG-----G 809

  Fly  1058 IGTAYEGYVKVPKSGVIKRGWIRQFVVV-CDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVG 1121
            || ...|:::|.:..:.:..|...:.:: .:...|..|...|             ::.:|.|::.
 Worm   810 IG-RMNGWLRVYRDDLPESTWTSLWAMMDSNHVKFYRDAGAD-------------NLENPYFTID 860

  Fly  1122 SVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTL----------MLADNESEKSKWVIAL--GE 1174
            ..:|..::...::          ..|.|.:..|.|          ::|.......:|...|  .:
 Worm   861 LNKEQWILRTGQE----------VAIPGDVMRNVLTIKLQTRSVHIVAPTPKSAERWAACLQNAQ 915

  Fly  1175 LHRILKRN--------------SLPNT-AIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDG 1224
            ..|::|.:              ||||. .|||.:.|.|                  .||..|:.|
 Worm   916 TRRMMKNSKPSSIAEYSCLLTLSLPNNLKIFKAHTIED------------------WILFATQTG 962

  Fly  1225 LFYINLDQ-YEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRAL-------------- 1274
            ||:.::.| ....||.....:..|..:.|...:.::....|.|.|:|:.:|
 Worm   963 LFFTSISQPRNPTRIAGPSSVTSLEVMSEINCVAMITNSNRQLALIPLDSLTLAMQSTHPSIRAE 1027

  Fly  1275 ---EASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKT 1336
               |...|..|:..:...         :||..:           ::.||:.:.:.|.||.
 Worm  1028 VLPEFGHVHTIRYHQQDG---------QRFLLV-----------SDDTQLHIRKYNSTRD----- 1067

  Fly  1337 CEFTIGYMAQHLQILSDMRLVVAHQSGF-----TAYFLRGEATAMSLVHPENQLCAFLNYSGVDA 1396
               ...:.|: |.:...:..:.:..:||     |.|::.                  |::.....
 Worm  1068 ---VFAHFAK-LVVPEPVSFIESTPAGFIFASDTFYYVP------------------LDHQSPSD 1110

  Fly  1397 VRVIEILCPSGGNF---------GEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHL 1452
            |...:::.|...::         .|.||.:|...|:|:|.|.:||::.|.:...|....:....|
 Worm  1111 VSARKLMPPRRSDYPVSAHAITANEILLAYQNHGIFVNLYGEQSRNQIIEWEKMPIEFAYTSPLL 1175

  Fly  1453 LVFSDTHLDI 1462
            .:..|..::|
 Worm  1176 YIVHDDSIEI 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	54/281 (19%)
		KELK	477..556	CDD:464876	18/79 (23%)
		CCDC158	<481..>894	CDD:464943	98/465 (21%)
		C1_MRCK	990..1042	CDD:410359	17/55 (31%)
		PH_MRCK	1049..1182	CDD:269949	22/145 (15%)
		CNH	1215..1484	CDD:459938	50/280 (18%)
		CRIB	1544..1580	CDD:238077
citk-1	NP_496914.1	SMC_prok_B	91..>699	CDD:274008	143/732 (20%)
		CRIK	737..794	CDD:410364	18/84 (21%)
		PH	813..915	CDD:214574	16/124 (13%)
		CNH	941..1222	CDD:214481	56/310 (18%)