Protein Alignment gek and citk-2

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: NP_494921.1
• Gene: citk-2 / 173864
• WormBaseID: WBGene00019087
• Length: 1286
• Species: Caenorhabditis elegans
• Alignment Length: 1258
• Identity: 253/1258 - (20%)
• Similarity: 445/1258 - (35%)
• Gaps: 388/1258 - (30%)

  Fly   436 STLDSKKNQSSGFGDDTL-DTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQH 499
            |||:.:|        .|| :||...|     .:..||   ..:|::...:|..|::   |||.:.
 Worm   124 STLEMEK--------QTLQETIQRAQ-----DDKKET---ETELESSRSRLHVLEK---ELSAKA 169

  Fly   500 NEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDS 564
            |::|  :.|:|  |.|...:.....|||  || ||||...:|:.|       ||:|       :.
 Worm   170 NDIF--MVTKD--LHDKNEELTSFRMEY--VT-KLSEANREKKAL-------EEKL-------EK 213

  Fly   565 LRNELRKSDKTRRELELHIEDAVIE--AAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSIS 627
            .:|:::::|  |:.|||:.|....:  .::.::|..|.|     ....:||.:|.:.
 Worm   214 YKNDMKEND--RKSLELNKEQVTTQNVLSEVRQLSAHFE-----FLTPVRKNASKIR-------- 263

  Fly   628 SEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKEL----------QQTQ 682
             |:..|                   |.:..:.:.|..::|:..|..|||||          .:..
 Worm   264 -ELDEY-------------------HQLSAKVIEESMNDLKIKNETLTKELSDKTELVKMKNEEL 308

  Fly   683 ERLKYTQMESITDSAET---------------------LLE----------LKKQHDLEKSSWFE 716
            |.|:.|...|:.||.:.                     |||          ||::.:.|:.....
 Worm   309 EDLRQTTTASLGDSEQATKYLHEENMKLTRQKADIRCELLEARRKVEGFDKLKQELEKERDDALA 373

  Fly   717 EKQRL---SSEVNLKSKSLKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQ 778
            :.|::   ...|..:.:||..|.||.||..:||:.|..:.        |:|:  .|.:.|:..|.
 Worm   374 DVQKIREVKRNVERELQSLTSLMAERDEQIEELKTKMFSF--------EMIK--KDHESAKNELS 428

  Fly   779 ALATKMTEELEYL----KHVGTFNNNGVDNKNWRNRRSQKLDKM--ELLNLQSAL--QREI---- 831
            ....|:.:..::|    :...||.:.....:..|.|..::.::|  .:.:||::|  ||::
 Worm   429 RTQEKLDQMGKHLIMADQQCSTFKSLKESAEGSRRRAIEQCNEMVVRIRDLQTSLESQRKVEQEV 493

  Fly   832 ---------QAKNM--ISDELSQTRSD------------------------LISTQKEVRDYKKR 861
                     |||.:  :.:|:.:...|                        |.....|:|..||.
 Worm   494 EMLKAENSRQAKKIEFMKEEIQEVHLDYRQELSRLAEKTKGKEDADHLRLTLSQRDSELRSAKKT 558

  Fly   862 YDSILHDFQKKETELRDLQKGGLEYSESFL--NKSTHHGLSSAF-----FRDMSKNSEIIDSAES 919
            ...:..|.||.:..|.:::    ::.|..|  |.....|::.|.     ::...:||:  ::.|.
 Worm   559 IQEVKADNQKVQLMLVEVR----QHQEKILEENVRLRKGMADALAKIEEYKRSWQNSQ--ETCER 617

  Fly   920 FGNESG----------DNFTPNFFQSGNSGMLFNY-----------EPKYAGKNNKDHSSMKEAS 963
            ...||.          :.......|...|..|..|           :|| .|:.:...|::.|..
 Worm   618 LERESATKEDKLDKLEEELQEKKQQIAESKELVTYLHSQIDAKQTKQPK-LGRRSTLLSTVSEMD 681

  Fly   964 VSDLSREESD--------------------QLVKESQKKVPGNTAIHQFLVRTFSSPT------- 1001
            .|...||..:                    |||...:.:...||.|........|..:
 Worm   682 TSVYMREAEEVRALEEQRQALMSNLAEKRRQLVDSKKSQSTANTTIVTTTTTEISKSSQSASELS 746

  Fly  1002 -------------------------KCNHCTSLMVGLT--RQGVVCEICGFACHTICCQKVPTTC 1039
                                     ||:.|   .||::  .:...|..|....|..|..:|..||
 Worm   747 NRQGTMRHDIPHKWKAFRHVGVLSMKCSLC---FVGISAFAKAKKCSHCDVHVHASCAPRVNNTC 808

  Fly  1040 PVPMDQTKRPLGIDPTRGIGTAY-EGYVKVPKSGVIK---RGWIRQFVVVCDFKLFLYDISPDRC 1100
            .:|:.             ..|.| |.:..|..|||.:   .||:|  |...|.....:..|....
 Worm   809 GMPLQ-------------CATYYRENHTTVSSSGVSEGRMNGWLR--VYRDDMTGSTWIASWAMM 858

  Fly  1101 ALPSVS--VSQVLDMRDPEFSVGSVRESDVIHAAKK-DVPCIFKIKTALIDGGLSLNTLM----- 1157
            .|..:|  .:...|:..|.||:...:|..|:...:: .|.|         |..:..|.::
 Worm   859 DLTRISFYTNDGADLEKPFFSIDLNKEQWVLRTGQEMPVDC---------DDSMRANNVLMIKMP 914

  Fly  1158 ------LADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIY--- 1213
                  ||.::....:|...|....|  ||..|.:    |.:.|.:.|..|:.|:..::.|:
 Worm   915 RRCLYILAPSQPSARRWAECLQTAQR--KRMMLNS----KESSIAEFTCLLVLNSPNNLKIFKAY 973

  Fly  1214 --PNQILLGTEDGLFYINLDQ-YEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALE 1275
              .:.||..|:.|||:.::.| ....||.....:..|..:.|.:.:.::......|.::|:.:|
 Worm   974 TIEDWILFATQTGLFFTSISQPRNPMRIAGPNSVTSLEIMAEIKCVAMVANSSGQLAMIPLDSL- 1037

  Fly  1276 ASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFT 1340
                  |..::|..      ..||  |.|:..|        .|..::.|        ||:.
 Worm  1038 ------ILAMQSTQ------PSIR--PEILPEF--------EHVHMIKY--------HQQN---- 1068

  Fly  1341 IGYMAQHLQILSD-----MRLVVAHQSGFTAYFLRGEATAMSLVH--PENQL--CAFLNYSGVD- 1395
                .|...::||     :|...|.:..|:.|........:|.:.  |...:  |....|..:|
 Worm  1069 ----GQRFLLISDDTHLHVRKYNATRDIFSQYAKFDVPEPISFIESAPSGIIFACDTFYYVALDH 1129

  Fly  1396 ----AVRVIEILCPSGGNF---------GEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITF 1447
                .|...:::.|:...|         .|.||.:|...|:|:|.|.:||:..|.:...|....:
 Worm  1130 QTSSNVSARKLMSPNKNEFPISAQMINQNEVLLAYQNQGIFVNLHGEQSRNETIEWEKMPMEFIY 1194

  Fly  1448 CDGHLLVFSDTHLDIFN-TQTAE 1469
            ....|.:..|..::|.. ::|::
 Worm  1195 TSPFLYIVHDDSIEILEISETSD 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748
		KELK	477..556	CDD:464876	25/78 (32%)
		CCDC158	<481..>894	CDD:464943	107/507 (21%)
		C1_MRCK	990..1042	CDD:410359	13/85 (15%)
		PH_MRCK	1049..1182	CDD:269949	31/150 (21%)
		CNH	1215..1484	CDD:459938	56/280 (20%)
		CRIB	1544..1580	CDD:238077
citk-2	NP_494921.1	SMC_prok_B	49..>717	CDD:274008	141/684 (21%)
		C1	754..811	CDD:412127	12/59 (20%)
		PH	835..940	CDD:459697	22/115 (19%)
		CNH	965..1248	CDD:214481	57/292 (20%)