Protein Alignment gek and Lats1

DIOPT Version :9

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: NP_034820.1
• Gene: Lats1 / 16798
• MGIID: 1333883
• Length: 1129
• Species: Mus musculus
• Alignment Length: 409
• Identity: 146/409 - (35%)
• Similarity: 227/409 - (55%)
• Gaps: 73/409 - (17%)

  Fly    77 SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAE 141
            |::::|        ::.::.:..|..:|.:|.|||||||:.:.:.|:.:||.|.|.|.::|.|.:
Mouse   689 SNYIRL--------KRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQ 745

  Fly   142 TACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYIT 206
            .|..:.|||:|...|.:|:..|:|:|||..|||.||||..|||:::||.:. ...||::|:|||.
Mouse   746 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPENLARFYIA 809

  Fly   207 EMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCL------------------------ 247
            |:..|:.|:|::.::||||||||:|:|:.||::|.|||.|.
Mouse   810 ELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDF 874

  Fly   248 -----------------RLDKDGTVQ-----SNVAVGTPDYISPEILRAMEDGKGRYGTECDWWS 290
                             .|::....|     ::..||||:||:||:|  :..|   |...|||||
Mouse   875 SNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVL--LRTG---YTQLCDWWS 934

  Fly   291 LGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRL 355
            :||.::|||.|:.||.|::.:||..|::|.|...::|.|.    |:|..:.||:.||...||:||
Mouse   935 VGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQA----KLSPEASDLIIKLCRGPEDRL 995

  Fly   356 GQNGIQDFMDHPWFVGIDW-KNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTD-----SIPPSA 414
            |:||..:...||:|..||: .::||..|.|:|:::.||||||||..|.|...:|     :|..:.
Mouse   996 GKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGSEEENISDTL 1060

  Fly   415 NPAFSGFHLP---FIGFTF 430
            |..:.....|   |..|||
Mouse  1061 NGWYKNGKHPEHAFYEFTF 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	142/386 (37%)
		S_TKc	100..369	CDD:214567	118/314 (38%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
Lats1	NP_034820.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		UBA_like_SF	103..143	CDD:304366
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..216
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..276
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..317
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..407
		PPxY motif 1	372..375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	513..630
		Interaction with YAP1. /evidence=ECO:0000250	525..654
		PPxY motif 2	555..558
		STKc_LATS1	702..1083	CDD:270775	144/388 (37%)
		S_TKc	704..1009	CDD:214567	118/314 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1104..1129

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920