DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gek and Cit

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:XP_006530193.1 Gene:Cit / 12704 MGIID:105313 Length:2123 Species:Mus musculus


Alignment Length:2130 Identity:489/2130 - (22%)
Similarity:797/2130 - (37%) Gaps:742/2130 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            |.:.:||....|::|||..:|.:.|.||.|::.....:..:|:|:.|..||::..::|.|.|.||
Mouse    47 SREGMLDALFALFEECSQPALMKMKHVSSFVQKYSDTIAELRELQPSARDFEVRSLVGCGHFAEV 111

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .||:..:|..||||||:.|..:|.:.:.:.|.|||::|......||..|.|||||..||||||:|
Mouse   112 QVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEY 176

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            ..|||||:||:::||:|.|.|.:||:.|:|||::|:||:.||||||||:|:|:|:.||::|.|||
Mouse   177 QPGGDLLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFG 241

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAM-EDGKGRYGTECDWWSLGVCMYEMLYGETPFYAE 308
            |..:::.: .|.:.:.:|||||::||:|..| ||.:|.||.:|||||:||..|||:||:|||...
Mouse   242 SAAKMNSN-KVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEG 305

  Fly   309 SLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID 373
            :...|:..|||.|.....|...    |||....|||..|:|:.:.||...|:   ..||:|...|
Mouse   306 TSARTFNNIMNFQRFLKFPDDP----KVSSELLDLLQSLLCVQKERLKFEGL---CCHPFFARTD 363

  Fly   374 WKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTL 438
            |.|||..|.|:||.:.|..||||||..:.:..::.|:...:...|||..|||:||::        
Mouse   364 WNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSVCQLSPSGFSGEELPFVGFSY-------- 420

  Fly   439 DSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVF 503
             ||.....|..:..:.::.||  |.:.|...:..:.|.:|:...|:...::||...|.::.:||.
Mouse   421 -SKALGYLGRSESVVSSLDSP--AKVSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVE 482

  Fly   504 ERLKTQDSELQDAISQRNI---------------------AMMEYSEVTEK----LSELRNQKQK 543
            ..|..::.||:.:.:||::                     |.||.|:..:|    |.::|.|.:|
Mouse   483 AVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 547

  Fly   544 LSR--------QVRDK-------EEELDGAMQKNDSLRNELRKS--------------------- 572
            |..        ||.:.       ||:|..|.:::|...:|||:|                     
Mouse   548 LQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKV 612

  Fly   573 ----------------------------------------------------------------- 572
                                                                             
Mouse   613 VSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAV 677

  Fly   573 -----------------DKTRRELE-LH--------IEDAVIEAAK------------------- 592
                             ::..|||| ||        |:..::||.:                   
Mouse   678 KASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRE 742

  Fly   593 ------------------------EKKLRE-----------------HAEDCCRQLQMELRK--- 613
                                    |:|.||                 |.|:..:.|..:::|   
Mouse   743 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 807

  Fly   614 ------------------------------------------------------GSSSVETTMPL 624
                                                                  .:||:.|...:
Mouse   808 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNM 872

  Fly   625 SISSEMSS------YEIE-----------RLELQFSEKLSHQQTRHN-----MELEA-LREQFSE 666
            ....||.|      :.:|           :||.|. ||:|||.  |:     :|||. |||...|
Mouse   873 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL-EKISHQD--HSDKSRLLELETRLREVSLE 934

  Fly   667 LENANLALTKELQ-----------------------QTQERLKYTQMESITDSAETLLELKKQH- 707
            .|...|.|.::|.                       ::|.|...|::|..|..||..::....| 
Mouse   935 HEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 999

  Fly   708 ------------------DLEK--SSWFEEKQRLSSEVNLKSKSLKELQAEDDEIFK---ELRMK 749
                              |||:  :...|:...|:::....||.|.|....:|||.:   |:...
Mouse  1000 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 1064

  Fly   750 REAITLWERQMAEIIQWVSDEKDAR------GYLQALATKMTEELEYLKHVGTFNNNGVDNKN-- 806
            |..||  ||:|.     ::.:|.|:      ..::||.|..|...|.:..:...|:..::.:.  
Mouse  1065 RREIT--EREMQ-----LTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQW 1122

  Fly   807 --WRN-------------RRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVR 856
              ||:             |..|::...|..:...|.||..:::.::...:.:.::::::.|:.::
Mouse  1123 EAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALK 1187

  Fly   857 DYKKRYDSI---LHDFQKK----ETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKN---- 910
            :.|.:.:|:   |:|.:||    |...|.||: .||.......:............|:.||    
Mouse  1188 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ-KLETERELKQRLLEEQAKLQQQMDLQKNHIFR 1251

  Fly   911 -----SEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEP------------------------ 946
                 .|.:|.|:....|..|    ..:|..|..:|:::|.                        
Mouse  1252 LTQGLQEALDRADLLKTERSD----LEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 1312

  Fly   947 ----------------------------KYAGKNNK----------------------------- 954
                                        |.|.:..|                             
Mouse  1313 AKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 1377

  Fly   955 -DH------------------------------------SSMKEASVSDLSREESDQLVKESQKK 982
             ||                                    |..||:|..:   |.|.:|.:.....
Mouse  1378 TDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPE---EFSRRLKERMHHN 1439

  Fly   983 VPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMD--- 1044
            :|     |:|.|......|||..|.. .|...||...|..|...||..|...:|.||.:|.:   
Mouse  1440 IP-----HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYAT 1498

  Fly  1045 ----------------QTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKR---GWIRQFVVVCDFKL 1090
                            |:|.|       |.....||::|||::.  ||   ||.|:::|:...|:
Mouse  1499 HFTEAFCRDKMNSPGLQSKEP-------GSSLHLEGWMKVPRNN--KRGQQGWDRKYIVLEGSKV 1554

  Fly  1091 FLYDISPDRCALPSVSVSQVLDMRDPEFSV-GSVRESDVIHAAKKDVPCIFKIK----TALIDGG 1150
            .:||..........|...: |.:.|.:.|: |:|..|::.:.||.|||.|.|::    |....| 
Mouse  1555 LIYDNEAREAGQRPVEEFE-LCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPG- 1617

  Fly  1151 LSLNTL-MLADNESEKSKWVIALGEL---HRILKRNSLPNTAIFKVNEILDNTLS---------L 1202
               .|| :||.:..:|.:||.||..:   .|:.:..:..:.|       .|:|.|         |
Mouse  1618 ---RTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAA-------RDHTSSEHQPVWVEKL 1672

  Fly  1203 IRNAL------------CSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQI 1255
            :.|:|            |::......:|:|||:||:.:|:.:..:..|.....:.|::.|::.:.
Mouse  1673 LGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHIPGIGAVFQIYIIKDLEK 1737

  Fly  1256 LVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQ 1320
            |:::.|::|.|.|:        ||:.:|...:::.:.|...:   .|||..:.            
Mouse  1738 LLMIAGEERALCLV--------DVKKVKQSLAQSHLPAQPDV---SPNIFEAV------------ 1779

  Fly  1321 IVVYEINRTRTRHQKTCE-FTIGYMAQHLQILSDMR---LVVAHQSGFTAYFLRGE---ATAMSL 1378
                          |.|. |..|.:...|.|.:.|.   :::.:....:.|.:|.|   :...|.
Mouse  1780 --------------KGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLSKYCIRKEIETSEPCSC 1830

  Fly  1379 VHPENQLCAFLNYS---GVDAVRVIEI---------------LCP------------------SG 1407
            :|       |.|||   |.:....|::               |.|                  |.
Mouse  1831 IH-------FTNYSILIGTNKFYEIDMKQYTLDEFLDKNDHSLAPAVFASSSNSFPVSIVQANSA 1888

  Fly  1408 GNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQ 1472
            |...||||.|....::||..||:||..::.:...|....:.:.:|.|.....|::...|..   .
Mouse  1889 GQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQAR---S 1950

  Fly  1473 SIG--LKQSLPLNN---LGNVVLSSVNDTPLIVYLSN--------IHTKGLLQYRDGNRKGLPSI 1524
            |:|  .:..|.:.|   ||..:.|..      :||::        |..||.|....|.       
Mouse  1951 SLGSPARAYLEIPNPRYLGPAISSGA------IYLASSYQDKLRVICCKGNLVKESGT------- 2002

  Fly  1525 KRRFSIREINKTIKSDRRSKMISAPTNFN-HI-----SHMGPGDGIQNQR 1568
                   |.::...:.|.|.....|..:| ||     |...|.:|..:.|
Mouse  2003 -------EQHRVPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPR 2045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 152/332 (46%)
S_TKc 100..369 CDD:214567 125/269 (46%)
KELK 478..556 CDD:292424 26/117 (22%)
CEP63 492..749 CDD:293650 94/595 (16%)
CEP63 652..880 CDD:293650 64/310 (21%)
C1_1 990..1040 CDD:278556 17/49 (35%)
PH_MRCK 1049..1182 CDD:269949 42/144 (29%)
CNH 1211..1486 CDD:279162 64/322 (20%)
CRIB 1544..1580 CDD:238077 8/31 (26%)
CitXP_006530193.1 STKc_CRIK 96..421 CDD:270752 152/341 (45%)
Smc 473..1372 CDD:224117 144/913 (16%)
C1 1442..1490 CDD:237996 16/48 (33%)
PH 1523..1642 CDD:214574 39/125 (31%)
CNH 1687..1983 CDD:214481 70/348 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.