Protein Alignment gek and Cdc42bpb

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: XP_006240624.1
• Gene: Cdc42bpb / 113960
• RGDID: 621753
• Length: 1730
• Species: Rattus norvegicus
• Alignment Length: 1758
• Identity: 743/1758 - (42%)
• Similarity: 1049/1758 - (59%)
• Gaps: 228/1758 - (12%)

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |.|.||..|:.:|    .|..|..|       ...|::.|||..:.||.|||:|:|||:|.|::|
  Rat     2 SAKVRLKKLEQLL----LDGPWRNE-------SSLSVETLLDVLVCLYTECSHSALRRDKYVAEF 55

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            |:.:|||..:|:.::|.|:||:|:|:|||||||||.||:|.:||::|||||||||||||||||||
  Rat    56 LEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||.||.||||.|||||||...||||||||.||||||||||||||||||||:|||.||:
  Rat   121 FREERDVLVNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:||||:.||||||||||||||..||:|||||||||:::.||||||:||||||||||||||:|
  Rat   186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 250

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSET 339
            ||||.|:||.||||||||||||||||||||||||||||||||||||:..|..||..|   .|||.
  Rat   251 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVT---DVSEE 312

  Fly   340 SQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDV 404
            ::||:.:|||..|.|||||||:||..|.:|.|::|:|||...|||:|:||||:|||||||||:.:
  Rat   313 AKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVL 377

  Fly   405 RLTDSIPPSANPAFSGFHLPFIGFTF-------------SLTSSSTLD----------------- 439
            |..:.:||.::..|||.|||||||||             |:..|:||.
  Rat   378 RNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMIQSNTLTKDEDVQRDLENSLQIEA 442

  Fly   440 ---------------SKKNQSS------------GFGDDTLD--------TISSPQLAILPSNNS 469
                           |:|.|.|            ..|:...|        .:...:..:..||..
  Rat   443 YERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRL 507

  Fly   470 ETPV-----------DSVQ-LKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNI 522
            |..:           ||.| ||.|..|....:|||.||.||..|..||||:|..||:||..||..
  Rat   508 ERQLEDTVTLRQEHEDSTQRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKR 572

  Fly   523 AMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAV 587
            |:.|:||:.|:::|||:||||:|||:||||||::.||||.||:|.::|||:|:|:|||..:||||
  Rat   573 ALQEFSELNERMAELRSQKQKVSRQLRDKEEEMEVAMQKIDSMRQDIRKSEKSRKELEARLEDAV 637

  Fly   588 IEAAKEKKLREHAEDCCRQLQMEL-----RKGSSSVETTMPLSISSEMSSY--EIERLELQFSEK 645
            .||:||:|||||:|...:|::.||     ::|......|  |....|:|..  |:|:..|.:.|:
  Rat   638 AEASKERKLREHSESFSKQMERELETLKVKQGGRGPGAT--LEHQQEISKIRSELEKKVLFYEEE 700

  Fly   646 LSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLE 710
            |..::..|.:|::.::::..|.|:..|||.||:...:::|:.::.|..::..|.:..:|.:::.|
  Rat   701 LVRREASHVLEVKNVKKEVHESESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGAMKDKYERE 765

  Fly   711 KSSWFEEKQRLSSEVNLKSKSLKELQAE----DDEIFKELRMKREAITLWERQMAEIIQWVSDEK 771
            ::..|:|.::|::|.......:.:|.|:    :||: ::|..|:|::..||.|:|||||||||||
  Rat   766 RAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDEL-QDLASKKESVAHWEAQIAEIIQWVSDEK 829

  Fly   772 DARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNM 836
            ||||||||||:|||||||.|:. .:..:..:| ..|:.|||||||....|.|||||:.||:||.:
  Rat   830 DARGYLQALASKMTEELETLRS-SSLGSRTLD-PLWKVRRSQKLDMSARLELQSALEAEIRAKQL 892

  Fly   837 ISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQ--KKETE----------LRDLQKGGLEYSES 889
            :.:||.:.:...::.:.::::.:.:...:|.:.|  ||..|          |.|.|....||
  Rat   893 VHEELRKVKDTSLAFESKLKESEAKNRELLEEMQSLKKRMEEKFRADTGLKLPDFQDPIFEY--- 954

  Fly   890 FLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNK 954
            |......|.|:   |||                        :...|..|.:|..:|...:..:.:
  Rat   955 FNTAPLAHDLT---FRD------------------------SLSSSSASSLLALWEDTSSASDQE 992

  Fly   955 DHSSMKEASVS---DLSREESDQLVKESQK----KVPGNTAI---------HQFLVRTFSSPTKC 1003
            ..:|..:.|.|   ..|.|:.:...:..|:    .:|...|:         |||.:::|.|||:|
  Rat   993 TQASKLDLSPSVSVATSTEQQEDAARSQQRPSTVPLPNTQALAMAGPKPKAHQFSIKSFPSPTQC 1057

  Fly  1004 NHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKV 1068
            :|||||||||.|||..||:|.|:||..|....|..||:|.:|:|||||:|..|||||||:|||||
  Rat  1058 SHCTSLMVGLIRQGYACEVCAFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKV 1122

  Fly  1069 PKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAK 1133
            ||...:|:||.|.:.||||.||||||:...:...|.|..|||||:||.||:|.||..||||||.:
  Rat  1123 PKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFAVSSVLASDVIHATR 1187

  Fly  1134 KDVPCIFKIKTALIDGGLSLNTLM-LADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILD 1197
            :|:||||::..:|:......::|: |.:||:||.|||..|..|..||.:|.|.:..:....|..|
  Rat  1188 RDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLRSQVVHVAQEAYD 1252

  Fly  1198 NTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGK 1262
            ::|.||:..|.:.|:..::|.:|.|:||:.|.|.:..|.|..:.||:.|:....:|:::::|||:
  Rat  1253 SSLPLIKTVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKLILLLCGR 1317

  Fly  1263 QRNLRLLP---IRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVY 1324
            ..::.|.|   ....|||:.: ||:.|:|.|....||.:|:..:.  ...:|:||     .::.|
  Rat  1318 NHHVHLYPWTSFDGAEASNFD-IKLPETKGCQLIATGTLRKSSST--CLFVAVKR-----LVLCY 1374

  Fly  1325 EINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFL 1389
            ||.||:..|:|..|.......|.:.:..| ||.|.:.|||:...::|:...:.||:|.:...|||
  Rat  1375 EIQRTKPFHRKFNEIVAPGHVQWMAMFKD-RLCVGYPSGFSLLSIQGDGQPLDLVNPADPSLAFL 1438

  Fly  1390 NYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLV 1454
            :....||:..:|:      ...||||.|..:.:|||.|||:||.:|:|:||.|...:....|:.|
  Rat  1439 SQQSFDALCAVEL------KSEEYLLCFSHMGLYVDPQGRRSRTQELMWPAAPVACSCSSSHVTV 1497

  Fly  1455 FSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKGLLQY---RDG 1516
            :|:..:|:|:.:|.||||:|||::..|||:.|::.|... :.|.::|..|..:..:|..   .|.
  Rat  1498 YSEYGVDVFDVRTMEWVQTIGLRRIRPLNSDGSLNLLGC-EPPRLIYFKNKFSGTVLNVPDTSDN 1561

  Fly  1517 NRKGL--PSIKRRFSIREINKTIKSDR-------------RSKMISAPTNFNHISHMGPGDGIQN 1566
            ::|.:  ...||||    :.|..:.:|             ||||||.||||||::|||||||:
  Rat  1562 SKKQMLRTRSKRRF----VFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGM-- 1620

  Fly  1567 QRLLDLP----TTLETADQACSPIIHSLSCIPQ---SRKSNFLEQVDANSDDYGNDNIISRTPSP 1624
            |.|:|||    .|.:...|..:|     :.:|:   ||...::....:...:.|       .|.|
  Rat  1621 QVLMDLPLSAAPTAQEEKQGPAP-----TGLPRQLPSRNKPYVSWPSSGGSEPG-------VPVP 1673

  Fly  1625 MAS 1627
            :.|
  Rat  1674 LRS 1676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	247/331 (75%)
		KELK	477..556	CDD:464876	45/79 (57%)
		CCDC158	<481..>894	CDD:464943	173/435 (40%)
		C1_MRCK	990..1042	CDD:410359	30/51 (59%)
		PH_MRCK	1049..1182	CDD:269949	71/133 (53%)
		CNH	1215..1484	CDD:459938	91/271 (34%)
		CRIB	1544..1580	CDD:238077	23/39 (59%)
Cdc42bpb	XP_006240624.1	STKc_MRCK_beta	3..411	CDD:270774	280/421 (67%)
		Myosin_tail_1	426..>934	CDD:460256	180/512 (35%)
		KELK	527..606	CDD:464876	44/78 (56%)
		C1_MRCKbeta	1044..1096	CDD:410415	30/51 (59%)
		PH_MRCK	1103..1237	CDD:269949	71/133 (53%)
		CNH	1268..1527	CDD:459938	91/273 (33%)