DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and Cdc42bpb

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_006240624.1	Gene:	Cdc42bpb / 113960	RGDID:	621753	Length:	1730	Species:	Rattus norvegicus

Alignment Length:	1758	Identity:	743/1758 - (42%)
Similarity:	1049/1758 - (59%)	Gaps:	228/1758 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDF 79
            |.|.||..|:.:|    .|..|..|       ...|::.|||..:.||.|||:|:|||:|.|::|
  Rat     2 SAKVRLKKLEQLL----LDGPWRNE-------SSLSVETLLDVLVCLYTECSHSALRRDKYVAEF 55

  Fly    80 LKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETAC 144
            |:.:|||..:|:.::|.|:||:|:|:|||||||||.||:|.:||::|||||||||||||||||||
  Rat    56 LEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120

  Fly   145 FREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMI 209
            |||||||||.||.||||.|||||||...||||||||.||||||||||||||||||||:|||.||:
  Rat   121 FREERDVLVNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185

  Fly   210 LAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRA 274
            |||:||||:.||||||||||||||..||:|||||||||:::.||||||:||||||||||||||:|
  Rat   186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 250

  Fly   275 MEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSET 339
            ||||.|:||.||||||||||||||||||||||||||||||||||||:..|..||..|   .|||.
  Rat   251 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVT---DVSEE 312

  Fly   340 SQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDV 404
            ::||:.:|||..|.|||||||:||..|.:|.|::|:|||...|||:|:||||:|||||||||:.:
  Rat   313 AKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVL 377

  Fly   405 RLTDSIPPSANPAFSGFHLPFIGFTF-------------SLTSSSTLD----------------- 439
            |..:.:||.::..|||.|||||||||             |:..|:||.
  Rat   378 RNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMIQSNTLTKDEDVQRDLENSLQIEA 442

  Fly   440 ---------------SKKNQSS------------GFGDDTLD--------TISSPQLAILPSNNS 469
                           |:|.|.|            ..|:...|        .:...:..:..||..
  Rat   443 YERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRL 507

  Fly   470 ETPV-----------DSVQ-LKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNI 522
            |..:           ||.| ||.|..|....:|||.||.||..|..||||:|..||:||..||..
  Rat   508 ERQLEDTVTLRQEHEDSTQRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKR 572

  Fly   523 AMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAV 587
            |:.|:||:.|:::|||:||||:|||:||||||::.||||.||:|.::|||:|:|:|||..:||||
  Rat   573 ALQEFSELNERMAELRSQKQKVSRQLRDKEEEMEVAMQKIDSMRQDIRKSEKSRKELEARLEDAV 637

  Fly   588 IEAAKEKKLREHAEDCCRQLQMEL-----RKGSSSVETTMPLSISSEMSSY--EIERLELQFSEK 645
            .||:||:|||||:|...:|::.||     ::|......|  |....|:|..  |:|:..|.:.|:
  Rat   638 AEASKERKLREHSESFSKQMERELETLKVKQGGRGPGAT--LEHQQEISKIRSELEKKVLFYEEE 700

  Fly   646 LSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLE 710
            |..::..|.:|::.::::..|.|:..|||.||:...:::|:.::.|..::..|.:..:|.:::.|
  Rat   701 LVRREASHVLEVKNVKKEVHESESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGAMKDKYERE 765

  Fly   711 KSSWFEEKQRLSSEVNLKSKSLKELQAE----DDEIFKELRMKREAITLWERQMAEIIQWVSDEK 771
            ::..|:|.::|::|.......:.:|.|:    :||: ::|..|:|::..||.|:|||||||||||
  Rat   766 RAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDEL-QDLASKKESVAHWEAQIAEIIQWVSDEK 829

  Fly   772 DARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNM 836
            ||||||||||:|||||||.|:. .:..:..:| ..|:.|||||||....|.|||||:.||:||.:
  Rat   830 DARGYLQALASKMTEELETLRS-SSLGSRTLD-PLWKVRRSQKLDMSARLELQSALEAEIRAKQL 892

  Fly   837 ISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQ--KKETE----------LRDLQKGGLEYSES 889
            :.:||.:.:...::.:.::::.:.:...:|.:.|  ||..|          |.|.|....||
  Rat   893 VHEELRKVKDTSLAFESKLKESEAKNRELLEEMQSLKKRMEEKFRADTGLKLPDFQDPIFEY--- 954

  Fly   890 FLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNK 954
            |......|.|:   |||                        :...|..|.:|..:|...:..:.:
  Rat   955 FNTAPLAHDLT---FRD------------------------SLSSSSASSLLALWEDTSSASDQE 992

  Fly   955 DHSSMKEASVS---DLSREESDQLVKESQK----KVPGNTAI---------HQFLVRTFSSPTKC 1003
            ..:|..:.|.|   ..|.|:.:...:..|:    .:|...|:         |||.:::|.|||:|
  Rat   993 TQASKLDLSPSVSVATSTEQQEDAARSQQRPSTVPLPNTQALAMAGPKPKAHQFSIKSFPSPTQC 1057

  Fly  1004 NHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKV 1068
            :|||||||||.|||..||:|.|:||..|....|..||:|.:|:|||||:|..|||||||:|||||
  Rat  1058 SHCTSLMVGLIRQGYACEVCAFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKV 1122

  Fly  1069 PKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAK 1133
            ||...:|:||.|.:.||||.||||||:...:...|.|..|||||:||.||:|.||..||||||.:
  Rat  1123 PKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFAVSSVLASDVIHATR 1187

  Fly  1134 KDVPCIFKIKTALIDGGLSLNTLM-LADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILD 1197
            :|:||||::..:|:......::|: |.:||:||.|||..|..|..||.:|.|.:..:....|..|
  Rat  1188 RDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLRSQVVHVAQEAYD 1252

  Fly  1198 NTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGK 1262
            ::|.||:..|.:.|:..::|.:|.|:||:.|.|.:..|.|..:.||:.|:....:|:::::|||:
  Rat  1253 SSLPLIKTVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKLILLLCGR 1317

  Fly  1263 QRNLRLLP---IRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVY 1324
            ..::.|.|   ....|||:.: ||:.|:|.|....||.:|:..:.  ...:|:||     .::.|
  Rat  1318 NHHVHLYPWTSFDGAEASNFD-IKLPETKGCQLIATGTLRKSSST--CLFVAVKR-----LVLCY 1374

  Fly  1325 EINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFL 1389
            ||.||:..|:|..|.......|.:.:..| ||.|.:.|||:...::|:...:.||:|.:...|||
  Rat  1375 EIQRTKPFHRKFNEIVAPGHVQWMAMFKD-RLCVGYPSGFSLLSIQGDGQPLDLVNPADPSLAFL 1438

  Fly  1390 NYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLV 1454
            :....||:..:|:      ...||||.|..:.:|||.|||:||.:|:|:||.|...:....|:.|
  Rat  1439 SQQSFDALCAVEL------KSEEYLLCFSHMGLYVDPQGRRSRTQELMWPAAPVACSCSSSHVTV 1497

  Fly  1455 FSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKGLLQY---RDG 1516
            :|:..:|:|:.:|.||||:|||::..|||:.|::.|... :.|.::|..|..:..:|..   .|.
  Rat  1498 YSEYGVDVFDVRTMEWVQTIGLRRIRPLNSDGSLNLLGC-EPPRLIYFKNKFSGTVLNVPDTSDN 1561

  Fly  1517 NRKGL--PSIKRRFSIREINKTIKSDR-------------RSKMISAPTNFNHISHMGPGDGIQN 1566
            ::|.:  ...||||    :.|..:.:|             ||||||.||||||::|||||||:
  Rat  1562 SKKQMLRTRSKRRF----VFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGM-- 1620

  Fly  1567 QRLLDLP----TTLETADQACSPIIHSLSCIPQ---SRKSNFLEQVDANSDDYGNDNIISRTPSP 1624
            |.|:|||    .|.:...|..:|     :.:|:   ||...::....:...:.|       .|.|
  Rat  1621 QVLMDLPLSAAPTAQEEKQGPAP-----TGLPRQLPSRNKPYVSWPSSGGSEPG-------VPVP 1673

  Fly  1625 MAS 1627
            :.|
  Rat  1674 LRS 1676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	247/331 (75%)
		S_TKc	100..369	CDD:214567	210/268 (78%)
		KELK	478..556	CDD:292424	44/77 (57%)
		CEP63	492..749	CDD:293650	103/267 (39%)
		CEP63	652..880	CDD:293650	85/243 (35%)
		C1_1	990..1040	CDD:278556	28/49 (57%)
		PH_MRCK	1049..1182	CDD:269949	71/133 (53%)
		CNH	1211..1486	CDD:279162	93/277 (34%)
		CRIB	1544..1580	CDD:238077	23/39 (59%)
Cdc42bpb	XP_006240624.1	STKc_MRCK_beta	3..411	CDD:270774	280/421 (67%)
		S_TKc	76..342	CDD:214567	210/268 (78%)
		TPH	419..786	CDD:290579	119/368 (32%)
		KELK	528..606	CDD:292424	44/77 (57%)
		DMPK_coil	878..939	CDD:117396	16/60 (27%)
		C1	1044..1093	CDD:237996	28/48 (58%)
		PH_MRCK	1103..1237	CDD:269949	71/133 (53%)
		CNH	1263..1529	CDD:279162	93/280 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336829
Domainoid	1	1.000	439	1.000	Domainoid score	I533
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1157	1.000	Inparanoid score	I196
OMA	1	1.010	-	-		QHG52599
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	1	1.000	-	-		otm46258
orthoMCL	1	0.900	-	-		OOG6_103075
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1218
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810