DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gek and CIT

DIOPT Version :9

Sequence 1:NP_523837.2 Gene:gek / 37858 FlyBaseID:FBgn0023081 Length:1637 Species:Drosophila melanogaster
Sequence 2:XP_011536085.1 Gene:CIT / 11113 HGNCID:1985 Length:2084 Species:Homo sapiens


Alignment Length:2063 Identity:476/2063 - (23%)
Similarity:782/2063 - (37%) Gaps:697/2063 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            |.:.:||...||::|||..:|.:.|.||:|::.....:..:::|:.|..||::..::|.|.|.||
Human    47 SREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEV 111

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .||:..:|..:||||::.|..:|.:.:.:.|.|||::|......||..|.|||||..:|||||:|
Human   112 QVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEY 176

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            ..|||||:||:::||:|.|::.:||:.|:|||::|:|.:.||||||||:|:|:|:.||::|.|||
Human   177 QPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG 241

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAME-DGKGRYGTECDWWSLGVCMYEMLYGETPFYAE 308
            |..:::.:..|.:.:.:|||||::||:|..|. ||||.||.:|||||:||..|||:||.:||...
Human   242 SAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEG 306

  Fly   309 SLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID 373
            :...|:..|||.|.....|...    |||....||:..|:|..:.||...|:   ..||:|..||
Human   307 TSARTFNNIMNFQRFLKFPDDP----KVSSDFLDLIQSLLCGQKERLKFEGL---CCHPFFSKID 364

  Fly   374 WKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPA-FSGFHLPFIGFTFSLTSSST 437
            |.|||..|.|:||.:.|..||||||..:.:..::.| |...:|: |||..|||:||::       
Human   365 WNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSS-PCQLSPSGFSGEELPFVGFSY------- 421

  Fly   438 LDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEV 502
              ||.....|..:..:..:.||  |...|...:..:.|.:|:...|:...::||...|.::.:||
Human   422 --SKALGILGRSESVVSGLDSP--AKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEV 482

  Fly   503 FERLKTQDSELQDAISQRNI---------------------AMMEYSEVTEK----LSELRNQKQ 542
            ...|..::.||:.:.:||::                     |.||.|:..:|    |.::|.|.:
Human   483 EAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 547

  Fly   543 KLSR--------QVRDK-------EEELDGAMQKNDSLRNELRKSDKTRRELE----------LH 582
            ||..        ||.:.       ||:|..|.:::|...:|||:|.....|.:          |.
Human   548 KLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLK 612

  Fly   583 IED----AVIEAAKEKKLREHAEDCCRQLQMELRKG-SSSVETT---MPLSISSEMSSYEIERLE 639
            .:|    .|.|.||.:|:....:...::||.:|.|. .:|.|.|   ..:..:.|.:..|:|:| 
Human   613 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL- 676

  Fly   640 LQFSEKLSHQQTRHNMELEALREQFSELENANLALTKE------LQQTQERLK---YTQMESITD 695
                      |.|.:.. |.:|::..|.|....:|..:      :::.:.|||   .|:.:.|..
Human   677 ----------QNREDSS-EGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQ 730

  Fly   696 SAETLLELKKQH--------DLE-----KSSWFEEK----------------------QRLSSEV 725
            .|:.:|||:::|        .||     |...:|||                      ||...|.
Human   731 MADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 795

  Fly   726 NLKSKSLKELQAEDDEIFKELRMKREAIT--------------LWERQMAEIIQWVSDEKDARGY 776
            :.|.|.|.|.:|..:.:..::|...:.|.              ..:|.|....:.:|:.:..:.|
Human   796 HEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFY 860

  Fly   777 LQALA-------TKMTEELEYLKHVGTFNNNGV-------------------------------- 802
            |:..|       .|:.|:||.:.|....:.|.:                                
Human   861 LETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSL 925

  Fly   803 ----------------------------------------------------------------- 802
                                                                             
Human   926 QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 990

  Fly   803 ----------DNKNWRNRR---SQKLDKM-----ELLNLQSA---LQREIQAKNM---------- 836
                      ||....|:.   |::||:.     |::.|:|.   |:|||..:.|          
Human   991 LEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTME 1055

  Fly   837 ------------------ISDEL-------------------------------------SQTRS 846
                              ::|||                                     |:.|:
Human  1056 ALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARA 1120

  Fly   847 D--------------------LISTQKEVRDYKKRYDSI---LHDFQKK----ETELRDLQKGGL 884
            |                    :::.|:.:::.|.:.:|:   |:|.:||    |...|.||: .|
Human  1121 DQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ-KL 1184

  Fly   885 EYSESFLNKSTHHGLSSAFFRDMSKN---------SEIIDSAESFGNESGDNFTPNFFQSGNSGM 940
            |.......:............|:.||         .|.:|.|:....|..|    ..:|..|..:
Human  1185 ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD----LEYQLENIQV 1245

  Fly   941 LFNYEP----------------------------------------------------KYAGKNN 953
            |:::|.                                                    |.|.:..
Human  1246 LYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKE 1310

  Fly   954 K------------------------------DH-------------------------------- 956
            |                              ||                                
Human  1311 KARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLL 1375

  Fly   957 ----SSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQG 1017
                |..||:|..:   |.|.:|.:.....:|     |:|.|......|||..|.. .|...||.
Human  1376 APPSSRRKESSTPE---EFSRRLKERMHHNIP-----HRFNVGLNMRATKCAVCLD-TVHFGRQA 1431

  Fly  1018 VVCEICGFACHTICCQKVPTTCPVPMD-------------------QTKRPLGIDPTRGIGTAYE 1063
            ..|..|...||..|...:|.||.:|.:                   |||.|       ......|
Human  1432 SKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP-------SSSLHLE 1489

  Fly  1064 GYVKVPKSGVIKR---GWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSV-GSVR 1124
            |::|||::.  ||   ||.|:::|:...|:.:||..........|...: |.:.|.:.|: |:|.
Human  1490 GWMKVPRNN--KRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFE-LCLPDGDVSIHGAVG 1551

  Fly  1125 ESDVIHAAKKDVPCIFKIK----TALIDGGLSLNTL-MLADNESEKSKWVIAL------GELHR- 1177
            .|::.:.||.|||.|.|::    |....|    .|| :||.:..:|.:||.||      |.:.| 
Human  1552 ASELANTAKADVPYILKMESHPHTTCWPG----RTLYLLAPSFPDKQRWVTALESVVAGGRVSRE 1612

  Fly  1178 ---------ILKRNSLPNTAIFKVNEILDNTLSLIR-----NALCSVIIYPNQILLGTEDGLFYI 1228
                     .:....||..    |.::|.|:|..:.     :..|::......:|:|||:||:.:
Human  1613 KAEADAARDCVSYELLPAW----VQKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYAL 1673

  Fly  1229 NLDQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISA 1293
            |:.:..:..:.....:.|::.|::.:.|:::.|::|.|.|:        ||:.:|...:::.:.|
Human  1674 NVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLV--------DVKKVKQSLAQSHLPA 1730

  Fly  1294 CTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCE-FTIGYMAQHLQILSDMR-- 1355
            ...|   .|||..:.                          |.|. |..|.:...|.|.:.|.  
Human  1731 QPDI---SPNIFEAV--------------------------KGCHLFGAGKIENGLCICAAMPSK 1766

  Fly  1356 -LVVAHQSGFTAYFLRGE---ATAMSLVHPENQLCAFLNYS---GVDAVRVIEI----------- 1402
             :::.:....:.|.:|.|   :...|.:|       |.|||   |.:....|::           
Human  1767 VVILRYNENLSKYCIRKEIETSEPCSCIH-------FTNYSILIGTNKFYEIDMKQYTLEEFLDK 1824

  Fly  1403 ----LCP------------------SGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYI 1445
                |.|                  |.|...||||.|....::||..||:||..::.:...|...
Human  1825 NDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAF 1889

  Fly  1446 TFCDGHLLVFSDTHLDIFNTQTAEWVQSIG--LKQSLPLNN---LGNVVLSSVNDTPLIVYLSN- 1504
            .:.:.:|.|.....|::...|..   .|.|  .:..|.:.|   ||..:.|..      :||:: 
Human  1890 AYREPYLFVTHFNSLEVIEIQAR---SSAGTPARAYLDIPNPRYLGPAISSGA------IYLASS 1945

  Fly  1505 -------IHTKGLLQYRDG--------------NRKGLPSIKRRFSIR 1531
                   |..||.|....|              |::|.|:.....:.|
Human  1946 YQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKR 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gekNP_523837.2 STKc_DMPK_like 98..430 CDD:270748 149/333 (45%)
S_TKc 100..369 CDD:214567 119/269 (44%)
KELK 478..556 CDD:292424 26/117 (22%)
CEP63 492..749 CDD:293650 80/358 (22%)
CEP63 652..880 CDD:293650 73/502 (15%)
C1_1 990..1040 CDD:278556 17/49 (35%)
PH_MRCK 1049..1182 CDD:269949 42/157 (27%)
CNH 1211..1486 CDD:279162 64/322 (20%)
CRIB 1544..1580 CDD:238077
CITXP_011536085.1 STKc_CRIK 95..422 CDD:270752 149/343 (43%)
S_TKc 97..360 CDD:214567 119/269 (44%)
Smc 474..1335 CDD:224117 141/877 (16%)
C1 1405..1453 CDD:237996 16/48 (33%)
PH 1486..1605 CDD:278594 39/125 (31%)
CNH 1650..1946 CDD:214481 70/348 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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