DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gek and Stk38

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	NP_001344102.1	Gene:	Stk38 / 106504	MGIID:	2442572	Length:	465	Species:	Mus musculus

Alignment Length:	481	Identity:	185/481 - (38%)
Similarity:	269/481 - (55%)	Gaps:	78/481 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TGS--C-------KKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNS 68
            |||  |       |:|:|..|..|.:..|:  ..|:. |:.|..|..|:.:::. ..|.||  ..
Mouse     4 TGSTPCSSMSNHTKERVTMTKVTLENFYSN--LIAQH-EEREMRQKKLEKVMEE-EGLKDE--EK 62

  Fly    69 SLRRE---KGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKI 130
            .|||.   :..::||:|        ::.||..:||:.||:|||||||||.:||...|..||||||
Mouse    63 RLRRSAHARKETEFLRL--------KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKI 119

  Fly   131 LNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDK 195
            |.|.:||::.:....|.|||:||..|..|:..:.|:|||.:||||:|::..|||::|||.| :|.
Mouse   120 LRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDT 183

  Fly   196 LPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDK--------- 251
            |.|:..:|||.|.:|||:||||:.::||||||||:|||.:|||:|:|||.|..|.|
Mouse   184 LTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRN 248

  Fly   252 -------DGTVQSN------------------VAVGTPDYISPEILRAMEDGKGRYGTECDWWSL 291
                   |.|.|:.                  ..|||||||:||:.  |:.|   |...||||||
Mouse   249 LNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSL 308

  Fly   292 GVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLG 356
            ||.|||||.|..||.:|:..|||.|:||.:.....|.:    ..|||.::.|:.:..|..|:|:|
Mouse   309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPE----VPVSEKAKGLILRFCCEWEHRIG 369

  Fly   357 QNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFD-VDDNDVRLTDSIPPSANPA--F 418
            ..|:::..::.:|.|:||::||:.||....|:.|..|||||| ..::|: |..::..|::|.  :
Mouse   370 APGVEEIKNNLFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDI-LKPTVTTSSHPETDY 433

  Fly   419 SGFHLPFIGFTF----SLTSSSTLDS 440
            ......||.:|:    .||:...:.|
Mouse   434 KNKDWVFINYTYKRFEGLTARGAIPS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	155/368 (42%)
		S_TKc	100..369	CDD:214567	132/302 (44%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
Stk38	NP_001344102.1	Interaction with S100B. /evidence=ECO:0000250	62..87		8/32 (25%)
Stk38	NP_001344102.1	STKc_NDR1	87..462	CDD:270777	159/384 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920