DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and dmpk

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_009303323.1	Gene:	dmpk / 101886625	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	531	Identity:	245/531 - (46%)
Similarity:	338/531 - (63%)	Gaps:	48/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVC 115
            |..|||..:.:|.|..:|.|||||.|..||:.::|.|..|:|.|:||:||.|||:||||.|.||.
Zfish    30 LQTLLDLLVGVYQEFCSSPLRREKHVQRFLQWAEPLVRQVKKTRISREDFHILKVIGRGTFSEVA 94

  Fly   116 VVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYY 180
            :.:|.:|::|||:||:|||:||||.|.||::|||:||:.|||:|||.|||||||:..|||||.||
Zfish    95 LARMRNTQQVYAVKIMNKWDMLKRGEMACYQEEREVLLKGDRRWITELHYAFQDDDYLYLVMHYY 159

  Fly   181 CGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGS 245
            .|||||||||||.|.|||:||:||:.||::||:|:|.:.||||||||||:||...||.||.||||
Zfish   160 VGGDLLTLLSKFNDGLPEEMAQFYLAEMVMAIDSVHLLGYVHRDIKPDNILLTADGHARLGDFGS 224

  Fly   246 CLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESL 310
            ||||:.||.|.|.||||||||:|||:|||:|.| |.||::||||:||||.||||.|.|||||||:
Zfish   225 CLRLEDDGLVHSAVAVGTPDYLSPELLRAVEAG-GGYGSDCDWWALGVCAYEMLLGTTPFYAESI 288

  Fly   311 VETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWK 375
            .|||.||::.::.|..|:.   ..:|||.::.|:|.|:.....|||..|..||..||:|.|:||.
Zfish   289 SETYAKIIHFKDYFGFPAS---GVQVSEPARALVCSLLXERSERLGSGGSADFRSHPFFSGLDWS 350

  Fly   376 NIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDS 440
            ::...|.||.|:||:.||||||||.|:.:..|:::......|..|.||.|:|::::.|
Zfish   351 SLHLHPPPYRPDVSNATDTSNFDVLDDCLSETETLSDVMERAPVGVHLAFVGYSYTAT------- 408

  Fly   441 KKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQE-KAELSKQHNEVFE 504
               :.:|..|.:.|        |:...:.....||:.|:...||:..|::. .||:
Zfish   409 ---RETGALDRSSD--------IMMEIDQLQDTDSLHLQDKLDQVWQLRETITAEV--------- 453

  Fly   505 RLKTQDSELQDAISQRNIAMMEYSEVTEK----LSELRNQKQKLSRQVRDKEEELDGAMQKNDSL 565
             |...:|..:    :.|...::.|..||:    :.||:....|..|:.|:.|:|:.|       |
Zfish   454 -LSAPESPAE----KNNPERVDRSTETEQSDTHVQELQRHLHKAERRNRELEQEMAG-------L 506

  Fly   566 RNELRKSDKTR 576
            |.::.:....|
Zfish   507 REQILRLSAVR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	193/331 (58%)
		S_TKc	100..369	CDD:214567	166/268 (62%)
		KELK	478..556	CDD:292424	19/82 (23%)
		CEP63	492..749	CDD:293650	19/89 (21%)
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
dmpk	XP_009303323.1	PKc_like	77..406	CDD:304357	193/332 (58%)
		S_TKc	79..344	CDD:214567	166/268 (62%)
		bZIP	<482..513	CDD:304365	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D117302at33208
OrthoFinder	1	1.000	-	-		FOG0001346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020