Protein Alignment gek and LOC100497498

DIOPT Version :10

• Sequence 1: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Sequence 2: XP_002938754.3
• Gene: LOC100497498 / 100497498
• XenbaseID: XB-GENE-29083703
• Length: 1608
• Species: Xenopus tropicalis
• Alignment Length: 1647
• Identity: 652/1647 - (39%)
• Similarity: 952/1647 - (57%)
• Gaps: 152/1647 - (9%)

  Fly    50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEV 114
            |::.|:|..|.|...|:.:.|||:|.|::||..::||...|:::||.||||:|:|:|||||||||
 Frog    27 SMETLIDALICLCHACNAAPLRRDKNVTEFLAWAEPFSSKVKQMRLKRDDFEIVKVIGRGAFGEV 91

  Fly   115 CVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDY 179
            .||:|..:.|::|||||:|||||||||||||||||||||.||.|||.:|||||.|:..|||||||
 Frog    92 AVVKMKGSGKIFAMKILHKWEMLKRAETACFREERDVLVKGDTQWIPSLHYAFHDDNYLYLVMDY 156

  Fly   180 YCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG 244
            |.|||||||||||||:||||||:||:.||:|||:||||:.||||||||||||:|.:||:||||||
 Frog   157 YVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIDSIHQLNYVHRDIKPDNVLIDLKGHIRLADFG 221

  Fly   245 SCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAES 309
            |||::..||||:|:||||||||||||||:|||||||:||.|||||||||.|||:|:|||||||||
 Frog   222 SCLKMKPDGTVESSVAVGTPDYISPEILQAMEDGKGKYGIECDWWSLGVSMYELLFGETPFYAES 286

  Fly   310 LVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDW 374
            |||||||||||:.....||..|   .|||.::||:.:|||..|.|||:.||.||..||:|.|:||
 Frog   287 LVETYGKIMNHEEHLQFPSDIT---DVSEKAKDLIQRLICRKEERLGKGGIDDFKKHPFFNGVDW 348

  Fly   375 KNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFS-------- 431
            .|||....||.|||.||.|||||||||..::..|::||:.:..||...|||:||||:
 Frog   349 DNIRNAIPPYTPEVDSPADTSNFDVDDESLKNLDTLPPNNHNGFSAHLLPFVGFTFTSECSLSDR 413

  Fly   432 -----LTSSSTLDSKKNQSSGFGDDTLDT-------------ISSPQLAILPSNNSETPVDSVQL 478
                 ..||.|..|:|....|...:.|:.             |...:||:  :...:..:...|.
 Frog   414 GSLSCAVSSGTASSEKTTKPGQDKEQLNAKDGEIRSLKKEMEILQKKLAV--NAKEQEGLSGSQF 476

  Fly   479 KALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQK 543
            ::|..::.:|||||...:|:.:::.||||:|..||:.|:.::.....|.....||...|.:|..:
 Frog   477 QSLEKEIRSLKQEKESCNKELSDMLERLKSQGVELKAALEKKKTMQEELRGAEEKCESLNSQVGR 541

  Fly   544 LSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQ 608
            |:|:::|||:|::...:|...||..|.|::.:|||:|..|||..:|..|:|||||.:|....|..
 Frog   542 LTRRLKDKEDEVEATAEKVRLLRKNLHKAEGSRREIESQIEDLNLELEKQKKLRERSEALATQAT 606

  Fly   609 MELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQT--------------RHNMELEA 659
            .||....|....|.|: ||..:...|:.:|......:..|.:|              .|..|.::
 Frog   607 EELECLKSQQSITSPV-ISGSLHYSEMTQLRTDLERRSQHHETELERLRKELACREEEHATETKS 670

  Fly   660 LREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSE 724
            ||.:..|.|...::|..|::..||.|.....:......|.:.|::|.::.|::|..||.::|..|
 Frog   671 LRRELGERETELISLRHEMEALQESLGRKSSDRARAQEEEIQEMQKINERERNSLKEENKKLKQE 735

  Fly   725 VNLKSKSLKELQAEDDEIFKELRM---KREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTE 786
            :........:|.|....:.:||::   |::::..||.|:.:|:|||:|||.:|.|||||:.::|:
 Frog   736 LEKVLAESDKLAASHKSLEEELQLLDVKKDSLVNWETQVTDILQWVNDEKQSRVYLQALSVRLTD 800

  Fly   787 ELEYLKHV-GTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLIS 850
            ||:.||:. |...::......|:.||.|||:....|.|||||:.||:||..|.:||::.:|:..:
 Frog   801 ELDTLKNSGGQTPSSKTGESQWKARRLQKLEASARLELQSALEAEIKAKQCIQEELNRFKSESHN 865

  Fly   851 TQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSES-----FLNKSTHHGLSSAFFRDMSKN 910
            |::::::.::....:..:.:|...|.:  ||...|..:.     ||:..|.....:|  .|.::|
 Frog   866 TERKLQEAEEENRKLRAEVEKVREEAK--QKAITETKQQRPLIPFLSFRTEKDPINA--EDQTQN 926

  Fly   911 SEII--DS-AESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREES 972
            :.:|  || .||..|:                         ..:.:....:::|||
 Frog   927 NVMIRRDSRTESVKNK-------------------------VNRRSAGFDTIEEAS--------- 957

  Fly   973 DQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPT 1037
                 |..|.       |.|.|:||:|||||..|||:|:||.|||:.||:||:.||..|.:|.|
 Frog   958 -----EKMKS-------HAFKVKTFTSPTKCLRCTSVMIGLCRQGLCCEVCGYICHVSCSEKAP- 1009

  Fly  1038 TCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCAL 1102
            .||.|..|.|:.||:||..|.|||.||.:.|||...:::||.:.:|::.:||:.:||..|. |
 Frog  1010 ICPSPPSQIKKILGVDPVTGSGTALEGSLSVPKPAGVRKGWQKAYVILSEFKVLVYDACPP-C-- 1071

  Fly  1103 PSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNT-LMLADNESEKS 1166
             :.::.|.:||||..|||.||.|||||||:.||:||||:|..:.:....:.:: |:||:...|..
 Frog  1072 -NTAIIQAIDMRDENFSVSSVLESDVIHASTKDIPCIFRITFSQMSSPPTTSSQLLLAETGEEMQ 1135

  Fly  1167 KWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLD 1231
            |||..|.|||.:||.....:..:.|  |..|:.|.|||.|||:.||...::.||.|||||.::::
 Frog  1136 KWVQVLKELHGLLKGPHSQSVRVLK--EAYDSALPLIRTALCATIIDQERLALGNEDGLFLLHVN 1198

  Fly  1232 QYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTG 1296
            :.||.::|:.|::|.|..:.|.|.|.:||||..::||.....|...|...:|:.|:|.|.:..:|
 Frog  1199 KNEIMQLGDCKRVLALRCVPEAQQLAVLCGKSHSVRLFSWDLLLLPDSTGMKIPEAKGCHAIASG 1263

  Fly  1297 IIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQ 1361
            ::.:..:.|  ..:|.||     |:..:::...:...::..||....:.|.:.||.: ||.|.:.
 Frog  1264 LVCQGSSPV--LCVASKR-----QVYCFQLTSNKGSPRRIKEFQAAGVVQCMDILGE-RLCVGYS 1320

  Fly  1362 SGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDL 1426
            |||:.:.:..||..:.|.||......||..|..||      ||.:.....|:||.|.|..:|||.
 Frog  1321 SGFSLHPILNEAAPIQLPHPNEPKLTFLMQSTPDA------LCAARVTLSEFLLCFSTFGVYVDS 1379

  Fly  1427 QGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLS 1491
            ||||||.:|||:||.|....:...||.|||:..||||:.:.:||:|:|.||:...||..|::.:.
 Frog  1380 QGRKSRTQEIMWPAPPVACVYTAPHLTVFSENALDIFDVRRSEWIQTIPLKKVRSLNAEGSLCIF 1444

  Fly  1492 SVNDTPLIVYLSNIHTK----GLLQYRDGNRKGL--PSIKRRFSIREINKTIKSDR--------- 1541
            . ::...:|||.|....    .:.:..|.:|:.:  ...||.||.|..::..:..|
 Frog  1445 G-SEKVRLVYLRNKLADQDEFNVPETSDNSRRQMVRTKSKRHFSFRISDEERQQQRRVMMKDPEL 1508

  Fly  1542 RSKMISAPTNFNHISHMGPGDGIQNQRLLDLPTTLETADQACSPIIHSLSCIPQSRKSNFLEQVD 1606
            |||:||.|.||||:.|:|||||  ..:|.||....|...::....:.:..    |..|:.::.|.
 Frog  1509 RSKLISNPKNFNHLVHVGPGDG--KHQLKDLAVAQEEKRRSSGQDVSASG----SSLSSSIDNVK 1567

  Fly  1607 ANSDDYGNDNIISRTPSPMASS 1628
            .||....:::.:|.....|.||
 Frog  1568 RNSSSSQSEDSLSSPQGLMLSS 1589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	232/331 (70%)
		KELK	477..556	CDD:464876	27/78 (35%)
		CCDC158	<481..>894	CDD:464943	133/435 (31%)
		C1_MRCK	990..1042	CDD:410359	30/51 (59%)
		PH_MRCK	1049..1182	CDD:269949	59/133 (44%)
		CNH	1215..1484	CDD:459938	93/268 (35%)
		CRIB	1544..1580	CDD:238077	18/35 (51%)
LOC100497498	XP_002938754.3	Protein Kinases, catalytic domain	6..412	CDD:473864	253/387 (65%)
		Smc	<437..>902	CDD:440809	136/469 (29%)
		KELK	475..554	CDD:464876	27/78 (35%)
		C1_MRCKgamma	963..1014	CDD:410416	30/51 (59%)
		PH-like	1022..1149	CDD:473070	57/130 (44%)
		CNH	1180..1438	CDD:459938	94/271 (35%)