DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and stk38b

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_017208958.1	Gene:	stk38b / 100332206	ZFINID:	ZDB-GENE-081031-2	Length:	469	Species:	Danio rerio

Alignment Length:	484	Identity:	180/484 - (37%)
Similarity:	261/484 - (53%)	Gaps:	82/484 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDITTGSCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRRE 73
            |.:.:...|:|:|..|..|.:..|:   .....|:.|..|..|:.::|. ..|.||  ...:||.
Zfish     9 SSLMSNHTKERVTMAKVTLENFYSN---LITQHEEREMRQQKLEKVMDE-EGLPDE--EKRVRRS 67

  Fly    74 KGV---SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWE 135
            :..   ::||:|        ::.||..|||:.||:|||||||||.:||...|..|||||||.|.:
Zfish    68 QHARKETEFLRL--------KRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKAD 124

  Fly   136 MLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDM 200
            ||::.:.|..|.|||:||..|..|:..:.|:|||.:||||:|::..|||::|||.| :|.|.|:.
Zfish   125 MLQKEQVAHIRAERDILVQADSLWVVKMFYSFQDKLNLYLLMEFLPGGDMMTLLMK-KDTLTEEE 188

  Fly   201 AKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTV---------Q 256
            .:||:.|.:|||:.|||:.::||||||||:|||.:|||:|:|||.|..|.|....         |
Zfish   189 TQFYVAETVLAIDFIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSQ 253

  Fly   257 SN-------------------------VAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMY 296
            ||                         ..|||||||:||:.  |:.|   |...||||||||.||
Zfish   254 SNDLTFQHMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVIMY 313

  Fly   297 EMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQ 361
            |||.|..||.:|:..|||.|:|..:.....|.:    ..:||.:::|:.:..|..::|:|..|:.
Zfish   314 EMLIGYPPFCSETPQETYKKVMGWKETLVFPPE----VPISERAKELILRFCCEADHRIGAGGVD 374

  Fly   362 DFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFD-VDDNDVRLTDSIPPSANPAFSGFHLP- 424
            |...:.:|.|:|:.:||:.||....|:.|..|||||| ..|:|:     :.|: :|.....|.|
Zfish   375 DIKRNAFFEGVDYDHIRERPAAITIEIKSIDDTSNFDEFPDSDI-----LQPT-SPVVVSNHHPE 433

  Fly   425 ---------FIGFTF----SLTSSSTLDS 440
                     ||.:|:    .||:...:.|
Zfish   434 SDYKNKDWVFINYTYKRFEGLTARGAIPS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	154/376 (41%)
		S_TKc	100..369	CDD:214567	129/302 (43%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
stk38b	XP_017208958.1	PKc_like	87..465	CDD:304357	158/392 (40%)
stk38b	XP_017208958.1	S_TKc	89..382	CDD:214567	129/302 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920