DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and rock1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_021334267.1	Gene:	rock1 / 100329779	ZFINID:	ZDB-GENE-100712-2	Length:	1375	Species:	Danio rerio

Alignment Length:	1294	Identity:	395/1294 - (30%)
Similarity:	620/1294 - (47%)	Gaps:	243/1294 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFG 112
            :.:.|.|||:...|..:....:||:.|.:.||||..|..:..:|:||:..:|::::|:|||||||
Zfish    26 EVNTDCLLDSLDALVYDLDFPALRKNKSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFG 90

  Fly   113 EVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVM 177
            ||.:|:..:|.||||||:|:|:||:||:::|.|.||||::.|.:..|:..|.|||||:..||:||
Zfish    91 EVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVM 155

  Fly   178 DYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLAD 242
            :|..||||:.|:|.::  :||..|:||..|::||::.||.:.::|||:||||:||||.||::|||
Zfish   156 EYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLAD 218

  Fly   243 FGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYA 307
            ||:|::::|||.|:.:.|||||||||||:|:: :.|.|.||.||||||:||.:||||.|:|||||
Zfish   219 FGTCMKMNKDGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYA 282

  Fly   308 ESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGI 372
            :|||.||.|||||:|....|...    .:|:.::.|:|..:...|.|||:||:.:...|.:|...
Zfish   283 DSLVGTYSKIMNHKNALTFPEDS----DISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFFKND 343

  Fly   373 D--WKNIRQGPAPYVPEVSSPTDTSNFD--VDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF--- 430
            .  |:|||:..||.|||:|..|||||||  .:|.....|..||    .||.|..|||:|||:
Zfish   344 QWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIP----KAFVGNQLPFVGFTYYSN 404

  Fly   431 -SLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNN------------------SETPVDSV 476
             ..:..||:.:...:||...|.:|  :.:.|..|.....                  |.|.:|.:
Zfish   405 NLFSQESTIKTSDKRSSTKEDKSL--LENLQKRIYQLEEQVHSEMQLRDEMEQKCRASNTKLDKI 467

  Fly   477 QLKALNDQLAALKQ--------EKAELSKQHNEV-FERLKTQDSELQDAISQRNIAMMEYSEVTE 532
             :|.|:::....|.        ||.::..||... ::|...|::|     .:||:. .|.|.:.|
Zfish   468 -MKELDEESNLRKSVEANMSILEKDKIMIQHRATEYQRKADQEAE-----KRRNLE-NEVSTLKE 525

  Fly   533 KLSELRNQKQKLSRQVRDKEEELDGAM-QKNDSLRNE------LRKS----DKTRRELELHIEDA 586
            :|.:||    |:| |..||..:|...: :.||.||.|      ||||    .||..:||
Zfish   526 QLEDLR----KIS-QNNDKIAQLQNQLGEANDLLRAESDTVMRLRKSHTEMGKTMSQLE------ 579

  Fly   587 VIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQF------SEK 645
            .|....::|:|. ||...:||:.||.:..::::|...   |....|.||..|:::.      ::.
Zfish   580 SINRELQEKIRA-AESVKQQLEKELLQLQTTLDTERR---SCSQGSEEIRELQVRIMGLQEDNKN 640

  Fly   646 LSHQQTRHNMELEALREQFSELENANLAL-------TKELQQ------TQERLKYTQMESITDSA 697
            |....|:...|.:.::|:.:.||....:|       .|.|||      |:.|:...|   :||..
Zfish   641 LKQSLTKVETERKHVQERCNILEKEKNSLEIDLNYKLKTLQQRLDQELTEHRITKAQ---LTDKY 702

  Fly   698 ETLLELKK--QHDLEKSSWFE--------------EKQRLSSEVNLK------SKSLKELQAEDD 740
            |::.|.|.  .|.:|:....|              |||....|.:||      .:.:|:.:..:|
Zfish   703 ESIEESKSAAMHAVEQKVSEETTLRMRAESRVVEVEKQCSMLEFDLKQSVQKMEQLMKQKERLED 767

  Fly   741 EIFKELRMKREAITLWERQMA--EIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVD 803
            |: |:||::.|..| .:|.|:  |:..|..|.:..:|..:.|..::...||        |...|:
Zfish   768 EV-KDLRVQLEQET-GKRVMSQNELKNWKMDSERLKGTEKQLKQEINAALE--------NKRSVE 822

  Fly   804 ------NKNWRNRRSQKLDKMELLNLQ-----------SALQREIQAKNMISDELSQTRSDL--- 848
                  .|.:|....|..:..:.|..:           ..|:.||:.||..:.|..:...||
Zfish   823 FQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKDEIEEKNRQTQEALKRVQDLNSE 887

  Fly   849 ---ISTQKEVRDYKKRYDSILHDFQKKE-TEL-RDLQKGGLEYSESFLNKSTHHGLSSAFFRDMS 908
               :|.|.::...|...:.:....|::: .|| ::.:|....|.:....|.:.........:.::
Zfish   888 KESLSAQLDLTMTKAESEQLARALQEEQYVELSQEYKKAVSRYKQEISEKDSTISQLEDSNKTLT 952

  Fly   909 KNSEIIDSAESFGNE----SGDNFTPNFFQSGNSGMLFNYEP--------------KYAG-KNNK 954
            |:.||:...::..||    ....|.....:..|| :..|||.              |.|. .|.|
Zfish   953 KDVEILSKEKTEFNERIQAQEQEFAAEREELTNS-IKANYEKALNIERTLKTQAVNKLAEIMNRK 1016

  Fly   955 DHSSMKE-ASVSDLSREESDQLVKESQK-KVPGNTAIHQFLVRTFSSPTKCN--------HCT-- 1007
            |....|: .|.:||.::|     ||::| ::..|....:|....|....:.|        .||
Zfish  1017 DMKDQKKRGSTTDLRKKE-----KENRKLQLELNQEKEKFNHMAFKYQKELNEMQAQWAEECTYR 1076

  Fly  1008 -SLMVGLTRQGVVCEICGFACHTICCQ----KVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVK 1067
             .|.:.|..:....|......:.:..:    .|.:..|..:|.     .|..:|     .||::.
Zfish  1077 NELQMQLDSKESDIEQLREKLNDLQLRVDNSSVTSLQPDELDS-----NIAESR-----LEGWLA 1131

  Fly  1068 VPKSGVIKR-GWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHA 1131
            :|....||| ||.:|:|||...|:..|:...|:   ...:.|.|||: |..|.|..|.:.||..|
Zfish  1132 IPNRANIKRYGWKKQYVVVSSKKILFYNDEQDK---EQSNPSMVLDI-DKLFHVRPVTQGDVYRA 1192

  Fly  1132 AKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSKWV----IALGELHRILKRNSLPN 1186
            ...::|.||:|               |..||.|..|..    :..|:     |.|.||:
Zfish  1193 ETDEIPRIFQI---------------LYANEGECRKETDVESVPQGD-----KANCLPH 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	169/335 (50%)
		S_TKc	100..369	CDD:214567	138/268 (51%)
		KELK	478..556	CDD:292424	23/86 (27%)
		CEP63	492..749	CDD:293650	82/309 (27%)
		CEP63	652..880	CDD:293650	63/289 (22%)
		C1_1	990..1040	CDD:278556	9/64 (14%)
		PH_MRCK	1049..1182	CDD:269949	39/137 (28%)
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
rock1	XP_021334267.1	STKc_ROCK1	4..408	CDD:270772	186/392 (47%)
		SMC_N	<426..1105	CDD:330553	159/721 (22%)
		PH_ROCK	1124..1230	CDD:269948	39/134 (29%)
		C1	1234..1288	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920