DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gek and lats1

DIOPT Version :9

Sequence 1:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster
Sequence 2:	XP_017949762.1	Gene:	lats1 / 100145677	XenbaseID:	XB-GENE-959763	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	152/409 - (37%)
Similarity:	226/409 - (55%)	Gaps:	73/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAE 141
            |::::|        ::.::.:..|..:|.:|.|||||||:.:...|..:||||.|.|.::|.|.:
Frog   675 SNYIRL--------KRAKMEKSMFVKIKTLGIGAFGEVCLARKTDTNALYAMKTLRKKDVLLRNQ 731

  Fly   142 TACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYIT 206
            .|..:.|||:|...|.:|:..|:|:|||..|||.||||..|||:::||.:. ...|||:|:|||.
Frog   732 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GVFPEDLARFYIA 795

  Fly   207 EMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCL---------------RLDKDGTVQ 256
            |:..|:.|:|::.::||||||||:|:|:.||::|.|||.|.               .|.:|....
Frog   796 ELTCAVESVHKMDFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHLRQDSMDF 860

  Fly   257 SN-------------------------------VAVGTPDYISPEILRAMEDGKGRYGTECDWWS 290
            ||                               ..||||:||:||:|  :..|   |...|||||
Frog   861 SNEWGDPANCRCGDRLKPLEWRAARQHQRCLAHSLVGTPNYIAPEVL--LRTG---YTQLCDWWS 920

  Fly   291 LGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRL 355
            :||.:||||.|:.||.|:|.|||..|::..|...::|:|.    |:|..:.||:.||...||:||
Frog   921 VGVILYEMLVGQPPFLAQSPVETQMKVIKWQTTLHIPAQA----KLSPEASDLIVKLCRGPEDRL 981

  Fly   356 GQNGIQDFMDHPWFVGIDW-KNIRQGPAPYVPEVSSPTDTSNFD-VDDNDVRLTDSIPPSANPAF 418
            |:||:.:...||:|..||: .::||.||||.|.::.|||||||| ||...:...:....:.|...
Frog   982 GKNGVDEIKVHPFFKNIDFSSDLRQQPAPYTPTITHPTDTSNFDPVDPEKLWNDEDKDGNKNDTL 1046

  Fly   419 SGFHL-------PFIGFTF 430
            :|::.       .|..|||
Frog  1047 NGWYKNGKHPEHAFYEFTF 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	148/386 (38%)
		S_TKc	100..369	CDD:214567	124/314 (39%)
		KELK	478..556	CDD:292424
		CEP63	492..749	CDD:293650
		CEP63	652..880	CDD:293650
		C1_1	990..1040	CDD:278556
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
lats1	XP_017949762.1	UBA_LATS1	102..142	CDD:270580
lats1	XP_017949762.1	STKc_LATS1	688..1069	CDD:270775	150/388 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920