DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snama and MPE1

DIOPT Version :9

Sequence 1:	NP_611884.1	Gene:	snama / 37857	FlyBaseID:	FBgn0086129	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_012864.1	Gene:	MPE1 / 853806	SGDID:	S000001542	Length:	441	Species:	Saccharomyces cerevisiae

Alignment Length:	443	Identity:	114/443 - (25%)
Similarity:	173/443 - (39%)	Gaps:	122/443 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVHYKFKSTLNFDTITFDGLHISVGDLKREIVQQKRLGKIIDFDLQITNAQSKEEYKDDGFLIPK 66
            ::.|:|||..|...|.|||..::|.||||||:|:.:||...||.|:|.|..::|||.||.|:||:
Yeast     4 TIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPR 68

  Fly    67 NTTLIISRIPI-----AHPTKKGWEPPAA-ENA---FSAAP---AKQDNFNMDLSKMQG-TEEDK 118
            :|::|:.|.|.     .|...||....|| .||   .:..|   .|:.:.....:.:.| |||::
Yeast    69 STSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEER 133

  Fly   119 IQAM--------------MMQSTVDYDPKTYHRIKGQSQVGEVPASYRCNKCKKSGHWIKNCP-- 167
            |.:|              |..:|..:.....::...|...|..|..|.|.:|....|||||||
Yeast   134 IASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTN 198

  Fly   168 ----FVGGKDQQEVKRNTGIPRSFR-----DKPDAAENESAD----------FVLPAVQNQ---- 209
                |.|    :.::|.||||:.|.     |.......|.|.          ||:.....|
Yeast   199 SDPNFEG----KRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWED 259

  Fly   210 -----------------------EIPEDLICGICRDIFVDAVMI-PCCGSSFCDDCVRTSLLESE 250
                                   ::|:||.|.:...:....|.. .||...|..:.:..:|:||
Yeast   260 YQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVES- 323

  Fly   251 DSECPDCKEKNCSPGSLIPNRFLRNSVNAF--KNE-------------------------TGYNK 288
            |..||:|:.::....||:|::.....|..|  |.|                         .|.|.
Yeast   324 DFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNN 388

  Fly   289 SAAKPAAVKNEEKP-------------PVEKEVEKKPVAEV-EPEETEVKPEK 327
            :.:.|.:|.|...|             |:.......|.|.: .|.:.:..|:|
Yeast   389 NTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snama	NP_611884.1	COG5222	3..315	CDD:227547	110/427 (26%)
		DWNN	3..75	CDD:285936	34/71 (48%)
		zf-CCHC_2	148..167	CDD:290419	9/18 (50%)
		RING	217..260	CDD:238093	12/43 (28%)
MPE1	NP_012864.1	COG5222	1..441	CDD:227547	113/441 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345437
Domainoid	1	1.000	79	1.000	Domainoid score	I2048
eggNOG	1	0.900	-	-		E1_COG5222
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3617
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000125
OrthoInspector	1	1.000	-	-		oto99402
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15439
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1986
SonicParanoid	1	1.000	-	-		X138
TreeFam	1	0.960	-	-
	11	10.780